Chemical Compound Review:
AC1MHIZU [(2R)-1-[[4-[[(1S)-1- methoxycarbonyl-3...
Synonyms:
ZINC03821325
This record was replaced with 3005532.
- Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Morgan, M.A., Dolp, O., Reuter, C.W. Blood (2001)
- Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome. Efuet, E.T., Keyomarsi, K. Cancer Res. (2006)
- GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Miquel, K., Pradines, A., Sun, J., Qian, Y., Hamilton, A.D., Sebti, S.M., Favre, G. Cancer Res. (1997)
- The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. Vogt, A., Sun, J., Qian, Y., Hamilton, A.D., Sebti, S.M. J. Biol. Chem. (1997)
- Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298. Coxon, F.P., Helfrich, M.H., Van't Hof, R., Sebti, S., Ralston, S.H., Hamilton, A., Rogers, M.J. J. Bone Miner. Res. (2000)
- In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. Bordier, B.B., Ohkanda, J., Liu, P., Lee, S.Y., Salazar, F.H., Marion, P.L., Ohashi, K., Meuse, L., Kay, M.A., Casey, J.L., Sebti, S.M., Hamilton, A.D., Glenn, J.S. J. Clin. Invest. (2003)
- The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. Schmidmaier, R., Baumann, P., Simsek, M., Dayyani, F., Emmerich, B., Meinhardt, G. Blood (2004)
- Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells. Carloni, V., Pinzani, M., Giusti, S., Romanelli, R.G., Parola, M., Bellomo, G., Failli, P., Hamilton, A.D., Sebti, S.M., Laffi, G., Gentilini, P. Hepatology (2000)
- Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression. Doisneau-Sixou, S.F., Cestac, P., Faye, J.C., Favre, G., Sutherland, R.L. Int. J. Cancer (2003)
- Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. Lerner, E.C., Qian, Y., Hamilton, A.D., Sebti, S.M. J. Biol. Chem. (1995)
- Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta. Adnane, J., Bizouarn, F.A., Chen, Z., Ohkanda, J., Hamilton, A.D., Munoz-Antonia, T., Sebti, S.M. Oncogene (2000)
- Pharmacological-based translational induction of transgene expression in mammalian cells. Boutonnet, C., Boijoux, O., Bernat, S., Kharrat, A., Favre, G., Faye, J.C., Vagner, S. EMBO Rep. (2004)
- A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. Bordier, B.B., Marion, P.L., Ohashi, K., Kay, M.A., Greenberg, H.B., Casey, J.L., Glenn, J.S. J. Virol. (2002)
- Regulation of Fas-mediated apoptosis by N-ras in melanoma. Urquhart, J.L., Meech, S.J., Marr, D.G., Shellman, Y.G., Duke, R.C., Norris, D.A. J. Invest. Dermatol. (2002)
- The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts. Bernhard, E.J., Kao, G., Cox, A.D., Sebti, S.M., Hamilton, A.D., Muschel, R.J., McKenna, W.G. Cancer Res. (1996)
- Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages. Xu, H., An, H., Yu, Y., Zhang, M., Qi, R., Cao, X. J. Biol. Chem. (2003)
- Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. Coxon, F.P., Helfrich, M.H., Larijani, B., Muzylak, M., Dunford, J.E., Marshall, D., McKinnon, A.D., Nesbitt, S.A., Horton, M.A., Seabra, M.C., Ebetino, F.H., Rogers, M.J. J. Biol. Chem. (2001)
- Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway. Wei, S., Gilvary, D.L., Corliss, B.C., Sebti, S., Sun, J., Straus, D.B., Leibson, P.J., Trapani, J.A., Hamilton, A.D., Weber, M.J., Djeu, J.Y. J. Immunol. (2000)
- Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s). Liu, L., Moesner, P., Kovach, N.L., Bailey, R., Hamilton, A.D., Sebti, S.M., Harlan, J.M. J. Biol. Chem. (1999)
- Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Lerner, E.C., Zhang, T.T., Knowles, D.B., Qian, Y., Hamilton, A.D., Sebti, S.M. Oncogene (1997)
- Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism. Vitale, M., Di Matola, T., Rossi, G., Laezza, C., Fenzi, G., Bifulco, M. Endocrinology (1999)
- Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity. Cestac, P., Sarrabayrouse, G., Médale-Giamarchi, C., Rochaix, P., Balaguer, P., Favre, G., Faye, J.C., Doisneau-Sixou, S. Breast Cancer Res. (2005)
- Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome. Zeng, Q., Si, X., Horstmann, H., Xu, Y., Hong, W., Pallen, C.J. J. Biol. Chem. (2000)
- Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade. Oldham, S.M., Cox, A.D., Reynolds, E.R., Sizemore, N.S., Coffey, R.J., Der, C.J. Oncogene (1998)
- Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines. Maeda, N., Fu, W., Ortin, A., de las Heras, M., Fan, H. J. Virol. (2005)
- BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. Ikehara, N., Semba, S., Sakashita, M., Aoyama, N., Kasuga, M., Yokozaki, H. Int. J. Cancer (2005)