Disease relevance of Methyl acrylonitrile

• G.l.c.--mass-spectral analysis of headspace above cultures of Aeromonas and Moraxella spp. indicates the presence of isobutyronitrile, isobutyraldoxime O-methyl ether, methacrylonitrile and possibly methacrylaldoxime O-methyl ether [1].
• Investigation of methacrylonitrile metabolism and the metabolic basis for the differences in its toxicity in rats and mice [2].
• Methacrylonitrile did not induce mutations in any of several strains of Salmonella typhimurium, with or without S9 activation, and did not induce sex-linked recessive lethal mutations in germ cells of male Drosophila melanogaster fed methacrylonitrile during the larval stage [3].

Psychiatry related information on Methyl acrylonitrile

• In summary, gavage administration of methacrylonitrile to rats and mice resulted in dose-dependent lethargy, tremors, lacrimation, convulsions, and abnormal breathing [3].

High impact information on Methyl acrylonitrile

• Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition [4].
• Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice [5].
• Single dose blood toxicokinetics of methacrylonitrile in the F344 rat [6].
• Effect of methacrylonitrile on cytochrome P-450 2E1 (CYP2E1) expression in male F344 rats [7].
• Haematological and erythrocyte membrane changes induced by methacrylonitrile [8].

Chemical compound and disease context of Methyl acrylonitrile

• In the absence of significant maternal toxicity, allylnitrile caused embryolethality, fetotoxicity, and clear teratogenicity at 50 ppm, and n-butyronitrile and methacrylonitrile caused fetotoxicity at 200 ppm and 100 ppm, respectively [9].
• The interaction of methacrylonitrile (MeAN) with glutathione (GSH) was evaluated in aqueous solution and its in vivo potential to deplete GSH in male Sprague Dawley rats at the 0.5 LD50 dose of 100 mg MeAN/Kg body weight was investigated [10].

Biological context of Methyl acrylonitrile

• Toxicology of methacrylonitrile [11].
• Toxicity and tissue distribution of methacrylonitrile in rats [12].
• Brain lipid peroxidation and antioxidant status after acute methacrylonitrile intoxication [13].
• Methacrylonitrile induced oxidative stress in rat liver [14].
• Female rats administered 60 or 120 mg/kg methacrylonitrile had significantly longer estrous cycles than did the vehicle controls [3].

Anatomical context of Methyl acrylonitrile

• The relative effects of a series of eight saturated (acetonitrile, propionitrile and n-butyronitrile) and unsaturated (acrylonitrile, allylnitrile, methacrylonitrile, cis-2-pentenenitrile, and 2-chloroacrylonitrile) aliphatic nitriles were evaluated using an in vitro test for embryotoxicity, the rat limb bud micromass assay [15].
• Microscopically, the only target of methacrylonitrile toxicity was the olfactory epithelium of the nasal cavity [3].

Associations of Methyl acrylonitrile with other chemical compounds

• The status of brain antioxidant enzymes and glutathione in methacrylonitrile (MeAN)-intoxicated Wistar rats was correlated with the levels of lipid peroxidation products [13].
• In liver fractions from male Sprague-Dawley rats, the metabolism of methacrylonitrile (MeAN) to cyanide (CN-) was localized in microsomal fraction and required reduced nicotinamide adenine dinucleotide phosphate (NADPH) and oxygen for maximal activity [16].
• A photochemical cycloaddition reaction of methyl 2-pyrone-5-carboxylate with methacrylonitrile mainly gave a [4 + 2] cycloadduct, assigned as methyl endo-8-cyano-exo-8-methyl-3-oxo-2-oxabicyclo[2.2.2]oct-5-ene-6-carboxylate, whose structure was determined by an X-ray diffraction study [17].

Gene context of Methyl acrylonitrile

• NTP technical report on the toxicity studies of methacrylonitrile (CAS No. 126-98-7). Administered by gavage to F344/N rats and B6C3F1 mice [3].

Analytical, diagnostic and therapeutic context of Methyl acrylonitrile

• Determination of methacrylonitrile in serum using gas chromatography and flame ionization detection [18].
• Following intravenous administration of an equimolar (0.216 mmol/kg) radioactive dose of acrylonitrile (2-[14C]VCN, 11.5 mg/kg) or methacrylonitrile (2-[14C]MeVCN, 14.5 mg/kg), the tissue distribution, covalent interaction, and elimination were compared (at 5 min to 48 hr) in male Fischer 344 rats using whole-body autoradiography (WBA) [19].

References