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Gene Review

Cyp2e1  -  cytochrome P450, family 2, subfamily e,...

Rattus norvegicus

Synonyms: 4-nitrophenol 2-hydroxylase, CYPIIE1, Cyp2e, Cyp2e-1, Cytochrome P450 2E1, ...
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Disease relevance of Cyp2e1


Psychiatry related information on Cyp2e1


High impact information on Cyp2e1


Chemical compound and disease context of Cyp2e1


Biological context of Cyp2e1


Anatomical context of Cyp2e1


Associations of Cyp2e1 with chemical compounds


Physical interactions of Cyp2e1


Other interactions of Cyp2e1


Analytical, diagnostic and therapeutic context of Cyp2e1


  1. Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. Robin, M.A., Anandatheerthavarada, H.K., Biswas, G., Sepuri, N.B., Gordon, D.M., Pain, D., Avadhani, N.G. J. Biol. Chem. (2002) [Pubmed]
  2. Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress. Jones, B.E., Liu, H., Lo, C.R., Koop, D.R., Czaja, M.J. Antioxid. Redox Signal. (2002) [Pubmed]
  3. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. Robin, M.A., Sauvage, I., Grandperret, T., Descatoire, V., Pessayre, D., Fromenty, B. FEBS Lett. (2005) [Pubmed]
  4. The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats. Bardag-Gorce, F., French, B.A., Li, J., Riley, N.E., Yuan, Q.X., Valinluck, V., Fu, P., Ingelman-Sundberg, M., Yoon, S., French, S.W. Gastroenterology (2002) [Pubmed]
  5. Role of ethanol-inducible cytochrome P-450 2E1 in the development of hepatocellular carcinoma by the chemical carcinogen, N-nitrosodimethylamine. Tsutsumi, M., Matsuda, Y., Takada, A. Hepatology (1993) [Pubmed]
  6. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Zhao, P., Kalhorn, T.F., Slattery, J.T. Hepatology (2002) [Pubmed]
  7. Characterization of cytochrome P450 2E1 induction in a rat hepatoma FGC-4 cell model by ethanol. McGehee, R.E., Ronis, M.J., Cowherd, R.M., Ingelman-Sundberg, M., Badger, T.M. Biochem. Pharmacol. (1994) [Pubmed]
  8. Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes. Kim, Y.C., Kim, Y.G., Kim, E.J., Cho, M.K., Kim, S.G., Lee, M.G. Biopharmaceutics & drug disposition. (2003) [Pubmed]
  9. Binge ethanol exposure increases liver injury in obese rats. Carmiel-Haggai, M., Cederbaum, A.I., Nieto, N. Gastroenterology (2003) [Pubmed]
  10. Dietary saturated fatty acids: a novel treatment for alcoholic liver disease. Nanji, A.A., Sadrzadeh, S.M., Yang, E.K., Fogt, F., Meydani, M., Dannenberg, A.J. Gastroenterology (1995) [Pubmed]
  11. Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Bradford, B.U., Kono, H., Isayama, F., Kosyk, O., Wheeler, M.D., Akiyama, T.E., Bleye, L., Krausz, K.W., Gonzalez, F.J., Koop, D.R., Rusyn, I. Hepatology (2005) [Pubmed]
  12. Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Wang, P.Y., Kaneko, T., Wang, Y., Sato, A. Hepatology (1999) [Pubmed]
  13. Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase. Zhukov, A., Ingelman-Sundberg, M. Biochem. J. (1999) [Pubmed]
  14. Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes. Anundi, I., Lähteenmäki, T., Rundgren, M., Moldeus, P., Lindros, K.O. Biochem. Pharmacol. (1993) [Pubmed]
  15. Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): the role of urea in CYP2E1 induction by acute renal failure. Chung, H.C., Kim, S.H., Lee, M.G., Kim, S.G. Drug Metab. Dispos. (2002) [Pubmed]
  16. Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport. Zhukov, A., Ingelman-Sundberg, M. Eur. J. Biochem. (1997) [Pubmed]
  17. Intestinal toxicity of acrylonitrile: in vitro metabolism by intestinal cytochrome P450 2E1. Subramanian, U., Ahmed, A.E. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  18. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Raza, H., Prabu, S.K., Robin, M.A., Avadhani, N.G. Diabetes (2004) [Pubmed]
  19. Lipopolysaccharide induces CYP2E1 in astrocytes through MAP kinase kinase-3 and C/EBPbeta and -delta. Kelicen, P., Tindberg, N. J. Biol. Chem. (2004) [Pubmed]
  20. Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha. Liu, H., Jones, B.E., Bradham, C., Czaja, M.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  21. A novel lipopolysaccharide-modulated Jun binding repressor in intron 2 of CYP2E1. Tindberg, N., Bengtsson, I., Hu, Y. J. Neurochem. (2004) [Pubmed]
  22. Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane. Neve, E.P., Ingelman-Sundberg, M. J. Biol. Chem. (2000) [Pubmed]
  23. Mechanism of hepatic heme oxygenase-1 induction by isoflurane. Hoetzel, A., Leitz, D., Schmidt, R., Tritschler, E., Bauer, I., Loop, T., Humar, M., Geiger, K.K., Pannen, B.H. Anesthesiology (2006) [Pubmed]
  24. Molecular cloning of a cDNA for rat diabetes-inducible cytochrome P450RLM6: hormonal regulation and similarity to the cytochrome P4502E1 gene. Richardson, T.H., Schenkman, J.B., Turcan, R., Goldfarb, P.S., Gibson, G.G. Xenobiotica (1992) [Pubmed]
  25. In vivo effect of diallyl sulfide and cimetidine on phenacetin metabolism and bioavailability in rat. Szutowski, M.M., Zalewska, K., Jadczak, M., Marek, M. Acta Biochim. Pol. (2002) [Pubmed]
  26. Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1. Nieto, N., Cederbaum, A.I. J. Biol. Chem. (2003) [Pubmed]
  27. Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism. Tindberg, N. J. Neurochem. (2003) [Pubmed]
  28. Ethylbenzene-mediated induction of cytochrome P450 isozymes in male and female rats. Sequeira, D.J., Eyer, C.S., Cawley, G.F., Nick, T.G., Backes, W.L. Biochem. Pharmacol. (1992) [Pubmed]
  29. cDNA sequence, deduced amino acid sequence, predicted gene structure and chemical regulation of mouse Cyp2e1. Freeman, J.E., Stirling, D., Russell, A.L., Wolf, C.R. Biochem. J. (1992) [Pubmed]
  30. Cytochrome P-450 2E1 in rat liver peroxisomes: downregulation by ischemia/reperfusion-induced oxidative stress. Pahan, K., Smith, B.T., Singh, A.K., Singh, I. Free Radic. Biol. Med. (1997) [Pubmed]
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