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Gene Review

Cyp2e1  -  cytochrome P450, family 2, subfamily e,...

Mus musculus

Synonyms: 4-nitrophenol 2-hydroxylase, CYPIIE1, Cyp2e, Cyp2e-1, Cytochrome P450 2E1, ...
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Disease relevance of Cyp2e1

  • In conclusion, forced overfeeding with a high-fat diet in mice induces obesity, insulin resistance, and SH in the absence of TNF signaling or Cyp2e1 induction [1].
  • These findings indicate that metabolism is obligatory for the development of chloroform-induced hepatic, renal, and nasal toxicity and that cytochrome P450 2E1 appears to be the only enzyme responsible for this cytotoxic-related metabolic conversion under these exposure conditions [2].
  • The expression of CYP 2E1 was slightly induced after single-dose and markedly induced after repeated dose-treatments of mice with hashish (10 mg kg(-1) body weight) [3].
  • Microscopic alterations included bronchoalveolar adenomas, and in one Cyp2e1+/+ mouse treated with 100 mg/kg urethane, a bronchoalveolar carcinoma was diagnosed [4].
  • The levels of expression of mRNA for a polycyclic aromatic hydrocarbon-inducible (CYP1A2) and an ethanol-inducible (CYP2E1) form of P-450 were reduced by 70% to 80% 8 to 12 hr after vaccination or Bordetella pertussis endotoxin administration [5].

High impact information on Cyp2e1


Chemical compound and disease context of Cyp2e1


Biological context of Cyp2e1


Anatomical context of Cyp2e1


Associations of Cyp2e1 with chemical compounds


Co-localisations of Cyp2e1


Regulatory relationships of Cyp2e1


Other interactions of Cyp2e1

  • Cytochrome P450 4a (Cyp4a) and Cyp2e1 are potential hepatic sources of ROS [29].
  • Targeted disruption of the HNF1alpha gene results in decreased Cyp1a2, and Cyp2e1 expression, and increased Cyp4a1 and Cyp7a1 expression, suggesting these enzymes are HNF1alpha target genes [30].
  • To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional expression of CYP1A2 and CYP2E1 was produced by cross-breeding Cyp1a2-/- mice with Cyp2e1-/- mice [31].
  • Cyp3a11 and Cyp2e1 mRNAs were not affected by any of the cytokines that were studied [32].
  • The present data indicate that while Cyp2e1 is still inducible in obese mice by xenobiotics and fasting, full constitutive expression of Cyp2e1 requires leptin to be present [23].

Analytical, diagnostic and therapeutic context of Cyp2e1


  1. Steatohepatitis induced by intragastric overfeeding in mice. Deng, Q.G., She, H., Cheng, J.H., French, S.W., Koop, D.R., Xiong, S., Tsukamoto, H. Hepatology (2005) [Pubmed]
  2. Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. Constan, A.A., Sprankle, C.S., Peters, J.M., Kedderis, G.L., Everitt, J.I., Wong, B.A., Gonzalez, F.L., Butterworth, B.E. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  3. Narcotic drugs change the expression of cytochrome P450 2E1 and 2C6 and other activities of carcinogen-metabolizing enzymes in the liver of male mice. Sheweita, S.A. Toxicology (2003) [Pubmed]
  4. Inhibition of urethane-induced carcinogenicity in cyp2e1-/- in comparison to cyp2e1+/+ mice. Ghanayem, B.I. Toxicol. Sci. (2007) [Pubmed]
  5. Modulation of hepatic mRNA levels after administration of lipopolysaccharide and diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP vaccine) to mice. Ansher, S.S., Thompson, W. Hepatology (1994) [Pubmed]
  6. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Ibdah, J.A., Perlegas, P., Zhao, Y., Angdisen, J., Borgerink, H., Shadoan, M.K., Wagner, J.D., Matern, D., Rinaldo, P., Cline, J.M. Gastroenterology (2005) [Pubmed]
  7. Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice. Demeilliers, C., Maisonneuve, C., Grodet, A., Mansouri, A., Nguyen, R., Tinel, M., Lettéron, P., Degott, C., Feldmann, G., Pessayre, D., Fromenty, B. Gastroenterology (2002) [Pubmed]
  8. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Lu, Y., Cederbaum, A.I. Hepatology (2006) [Pubmed]
  9. Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Wang, X., Lu, Y., Cederbaum, A.I. Hepatology (2005) [Pubmed]
  10. Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. Vaglini, F., Pardini, C., Viaggi, C., Bartoli, C., Dinucci, D., Corsini, G.U. J. Neurochem. (2004) [Pubmed]
  11. Ethanol and oxidative stress. Sun, A.Y., Ingelman-Sundberg, M., Neve, E., Matsumoto, H., Nishitani, Y., Minowa, Y., Fukui, Y., Bailey, S.M., Patel, V.B., Cunningham, C.C., Zima, T., Fialova, L., Mikulikova, L., Popov, P., Malbohan, I., Janebova, M., Nespor, K., Sun, G.Y. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  12. Olfactory toxicity of diethyldithiocarbamate (DDTC) and disulfiram and the protective effect of DDTC against the olfactory toxicity of dichlobenil. Deamer, N.J., Genter, M.B. Chem. Biol. Interact. (1995) [Pubmed]
  13. Protective effect of Moutan Cortex extract on acetaminophen-induced hepatotoxicity in mice. Shon, Y.H., Nam, K.S. Journal of ethnopharmacology. (2004) [Pubmed]
  14. In vitro model using mouse hepatocytes for study of alcohol stress. Yang, J.W., Shin, J.S., Lee, J.J., Chang, H.I., Kim, C.W. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  15. cDNA sequence, deduced amino acid sequence, predicted gene structure and chemical regulation of mouse Cyp2e1. Freeman, J.E., Stirling, D., Russell, A.L., Wolf, C.R. Biochem. J. (1992) [Pubmed]
  16. A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine. Delker, D.A., Bammler, T.K., Rosenberg, D.W. Drug Metab. Dispos. (1996) [Pubmed]
  17. Mouse ethanol-inducible cytochrome P-450 (P450IIE1). Characterization of cDNA clones and testosterone induction in kidney tissue. Davis, J.F., Felder, M.R. J. Biol. Chem. (1993) [Pubmed]
  18. Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. Yamazaki, H., Iketaki, H., Shibata, A., Nakajima, M., Yokoi, T. Drug Metab. Pharmacokinet. (2002) [Pubmed]
  19. Maintenance and activation of Cyp2e-1 gene expression in mouse hepatocytes in primary culture. Sakurai, J., Funae, Y., Nemoto, N. Biochim. Biophys. Acta (1996) [Pubmed]
  20. Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice. Wolf, K.K., Wood, S.G., Bement, J.L., Sinclair, P.R., Wrighton, S.A., Jeffery, E., Gonzalez, F.J., Sinclair, J.F. Drug Metab. Dispos. (2004) [Pubmed]
  21. A temporal study on the histopathological, biochemical and molecular responses of CCl(4)-induced hepatotoxicity in Cyp2e1-null mice. Avasarala, S., Yang, L., Sun, Y., Leung, A.W., Chan, W.Y., Cheung, W.T., Lee, S.S. Toxicology (2006) [Pubmed]
  22. Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: relevance to butadiene-induced bone marrow toxicity. Genter, M.B., Recio, L. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1994) [Pubmed]
  23. Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. Leclercq, I.A., Field, J., Enriquez, A., Farrell, G.C., Robertson, G.R. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  24. Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. Sinclair, J., Jeffery, E., Wrighton, S., Kostrubsky, V., Szakacs, J., Wood, S., Sinclair, P. Biochem. Pharmacol. (1998) [Pubmed]
  25. Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects. Kim, N.D., Kwak, M.K., Kim, S.G. Biochem. Pharmacol. (1997) [Pubmed]
  26. The acetaminophen regioisomer 3'-hydroxyacetanilide inhibits and covalently binds to cytochrome P450 2E1. Halmes, N.C., Samokyszyn, V.M., Hinton, T.W., Hinson, J.A., Pumford, N.R. Toxicol. Lett. (1998) [Pubmed]
  27. Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: relation to single strand breaks of DNA. Villard, P.H., Seree, E.M., Re, J.L., De Meo, M., Barra, Y., Attolini, L., Dumenil, G., Catalin, J., Durand, A., Lacarelle, B. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  28. Effect of natural phenols on the catalytic activity of cytochrome P450 2E1. Mikstacka, R., Gnojkowski, J., Baer-Dubowska, W. Acta Biochim. Pol. (2002) [Pubmed]
  29. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Ip, E., Farrell, G.C., Robertson, G., Hall, P., Kirsch, R., Leclercq, I. Hepatology (2003) [Pubmed]
  30. Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Maher, J.M., Slitt, A.L., Callaghan, T.N., Cheng, X., Cheung, C., Gonzalez, F.J., Klaassen, C.D. Biochem. Pharmacol. (2006) [Pubmed]
  31. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Zaher, H., Buters, J.T., Ward, J.M., Bruno, M.K., Lucas, A.M., Stern, S.T., Cohen, S.D., Gonzalez, F.J. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  32. Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver. Pan, J., Xiang, Q., Ball, S. Drug Metab. Dispos. (2000) [Pubmed]
  33. Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration. Forkert, P.G., Massey, T.E., Jones, A.B., Park, S.S., Gelboin, H.V., Anderson, L.M. Carcinogenesis (1991) [Pubmed]
  34. In situ hybridization analysis of hepatic cytochrome P450 2E1 messenger ribonucleic acid in mice. Modulation of expression by acetone. Forkert, P.G., Chen, S., Jackson, A.C. Lab. Invest. (1995) [Pubmed]
  35. Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration. Forkert, P.G., Redza, Z.M., Mangos, S., Park, S.S., Tam, S.P. Drug Metab. Dispos. (1994) [Pubmed]
  36. Evidence against a role for serine 129 in determining murine cytochrome P450 Cyp2e-1 protein levels. Freeman, J.E., Wolf, C.R. Biochemistry (1994) [Pubmed]
  37. CYP2E1-dependent benzene toxicity: the role of extrahepatic benzene metabolism. Bernauer, U., Vieth, B., Ellrich, R., Heinrich-Hirsch, B., Jänig, G.R., Gundert-Remy, U. Arch. Toxicol. (1999) [Pubmed]
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