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Chemical Compound Review

Embeline     [ (8S,9S,10S,11S,13S,14S,16S,17R )-17-(2...

Synonyms: Butavate, Temovate, Dermovate, Clobex, Cormax, ...
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Disease relevance of Cormax


High impact information on Cormax

  • The studies illustrated the applicability of the standardized pharmacodynamic modeling-based methodology in detecting the product differences between a variety of generic 0.05% CP formulations and reference Dermovate formulations in Chinese skin [6].
  • The estimates for the two formulations were not statistically different, so in vivo bioequivalence studies were conducted at an ED(50)dose duration of approximately 0.5 h for both Dermovate formulations [6].
  • Twenty patients with lesions of vitiligo were treated either with 0.I% betamethasone valerate (BV) or with 0.05% clobetasol propionate (CP) creams and similar control areas with placebo preparations [7].
  • Topical application of the CP cream completely inhibited the ear edema produced by croton oil [8].
  • Topical application of clobetasol-17-propionate inhibits the intra-epidermal accumulation of polymorphonuclear leukocytes [9].

Chemical compound and disease context of Cormax


Biological context of Cormax


Anatomical context of Cormax


Associations of Cormax with other chemical compounds


Gene context of Cormax

  • The results showed that the topical application of MLE immediately after CP treatment prevented the glucocorticoid-induced transepidermal water loss values increase [17].

Analytical, diagnostic and therapeutic context of Cormax


  1. Treatment of periocular capillary hemangioma with topical clobetasol propionate. Cruz, O.A., Zarnegar, S.R., Myers, S.E. Ophthalmology (1995) [Pubmed]
  2. The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion. Mrowietz, U., Graeber, M., Bräutigam, M., Thurston, M., Wagenaar, A., Weidinger, G., Christophers, E. Br. J. Dermatol. (1998) [Pubmed]
  3. Erosive pustular dermatosis of the leg. Bull, R.H., Mortimer, P.S. Br. J. Dermatol. (1995) [Pubmed]
  4. A new delivery system of clobetasol-17-propionate (lipid-loaded microspheres 0.025%) compared with a conventional formulation (lipophilic ointment in a hydrophilic phase 0.025%) in topical treatment of atrophic/erosive oral lichen planus. A Phase IV, randomized, observer-blinded, parallel group clinical trial. Campisi, G., Giandalia, G., De Caro, V., Di Liberto, C., Aricò, P., Giannola, L.I. Br. J. Dermatol. (2004) [Pubmed]
  5. Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity. Stuetz, A., Grassberger, M., Meingassner, J.G. Seminars in cutaneous medicine and surgery. (2001) [Pubmed]
  6. Evaluation of in vivo bioequivalence methodology for topical clobetasol 17-propionate based on pharmacodynamic modeling using Chinese skin. Tsai, J.C., Cheng, C.L., Tsai, Y.F., Sheu, H.M., Chou, C.H. Journal of pharmaceutical sciences. (2004) [Pubmed]
  7. The treatment of vitiligo with topical corticosteroids. Light and electronmicroscopic studies. Bleehen, S.S. Br. J. Dermatol. (1976) [Pubmed]
  8. Effect of RU 486 on the atrophogenic and antiinflammatory effects of glucocorticoids in skin. Iwasaki, K., Mishima, E., Miura, M., Sakai, N., Shimao, S. J. Dermatol. Sci. (1995) [Pubmed]
  9. Topical application of clobetasol-17-propionate inhibits the intra-epidermal accumulation of polymorphonuclear leukocytes. Chang, A., van de Kerkhof, P.C. Acta Derm. Venereol. (1988) [Pubmed]
  10. A double-blind, vehicle-controlled study of clobetasol propionate 0.05% (Temovate) scalp application in the treatment of moderate to severe scalp psoriasis. Olsen, E.A., Cram, D.L., Ellis, C.N., Hickman, J.G., Jacobson, C., Jenkins, E.E., Lasser, A.E., Lebwohl, M., Leibsohn, E., Medansky, R.S. J. Am. Acad. Dermatol. (1991) [Pubmed]
  11. Superpotent topical steroid treatment of psoriasis vulgaris--clinical efficacy and adrenal function. Katz, H.I., Hien, N.T., Prawer, S.E., Mastbaum, L.I., Mooney, J.J., Samson, C.R. J. Am. Acad. Dermatol. (1987) [Pubmed]
  12. Assessment of atrophy of human skin caused by corticosteroids using chamber occlusion and suction blister techniques. Somerma, S., Lassus, A., Salde, L. Acta Derm. Venereol. (1984) [Pubmed]
  13. Clinical studies of a new vehicle formulation for topical corticosteroids in the treatment of psoriasis. Stein, L. J. Am. Acad. Dermatol. (2005) [Pubmed]
  14. Venison contact dermatitis. Reiche, L. Australas. J. Dermatol. (2002) [Pubmed]
  15. Effects of glucocorticosteroids on cultured human skin fibroblasts. V. Influence of anabolic steroids on the inhibitory effects of clobetasol-17-propionate on cell proliferation and collagen synthesis. Ponec, M., de Haas, C., Kempenaar, J.A., Bachra, B.N. Arch. Dermatol. Res. (1979) [Pubmed]
  16. Selective persistence of dermal CD8+ T cells in lesional plaque psoriasis after clobetasol-17 propionate treatment. Bovenschen, H.J., Vissers, W.H., Seyger, M.M., van de Kerkhof, P.C. Acta Derm. Venereol. (2005) [Pubmed]
  17. Effects of a multilamellar emulsion on glucocorticoid-induced epidermal atrophy and barrier impairment. Ahn, S.K., Bak, H.N., Park, B.D., Kim, Y.H., Youm, J.K., Choi, E.H., Hong, S.P., Lee, S.H. J. Dermatol. (2006) [Pubmed]
  18. Pharmaceutical availability of clobetasol-17-propionate from cream and ointment. Dyderski, S., Grześkowiak, E., Szałek, E., Mrzygłód, A. Acta poloniae pharmaceutica. (2001) [Pubmed]
  19. Clobetasol-17 propionate lotion under hydrocolloid dressing (Duoderm ET) once weekly versus unoccluded clobetasol-17-propionate ointment twice daily in psoriasis: an immunohistochemical study on remission and relapse. van der Vleuten, C.J., van Vlijmen-Willems, I.M., de Jong, E.M., van de Kerkhof, P.C. Arch. Dermatol. Res. (1999) [Pubmed]
  20. Steroid-induced dermal thinning: discontinuous application of clobetasol-17-propionate ointment. Lubach, D., Rath, J., Kietzmann, M. Dermatology (Basel) (1992) [Pubmed]
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