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Chemical Compound Review

FLOXACILLIN     (2R,5R,6S)-6-[[3-(2-chloro-6- fluoro...

Synonyms: Floxapen, Fluclox, MFIPC, Flucloxacillin, flucloxacilina, ...
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Disease relevance of Flucloxacillin


High impact information on Flucloxacillin

  • INTERVENTION: Initial debridement and 2-week intravenous course of flucloxacillin or vancomycin with rifampin or placebo, followed by either ciprofloxacin-rifampin or ciprofloxacin-placebo long-term therapy [5].
  • However, encapsulation of flucloxacillin into liposomes could enable its entrance into the interior of neutrophils from two CGD patients to kill phagocytized bacteria there [6].
  • Commonly used antibiotics like flucloxacillin are of limited therapeutic value, because the staphylococci are protected against their action in the interior of phagocytes [6].
  • Minimum bacteriocidal concentrations of cloxacillin, flucloxacillin, cephalothin, and cephazolin in serum were much higher than conventional minimum inhibitory concentrations in the absence of serum [7].
  • 3. Moreover, flucloxacillin-specific T cell clones could be generated from peripheral blood, they expressed CD4 and the alphabeta-T cell receptor, and showed a heterogeneous cytokine secretion pattern with no clear commitment to either a Th1- or Th2-type response [8].

Chemical compound and disease context of Flucloxacillin


Biological context of Flucloxacillin


Anatomical context of Flucloxacillin


Associations of Flucloxacillin with other chemical compounds


Gene context of Flucloxacillin


Analytical, diagnostic and therapeutic context of Flucloxacillin


  1. Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureus. Entenza, J.M., Vouillamoz, J., Glauser, M.P., Moreillon, P. Antimicrob. Agents Chemother. (1997) [Pubmed]
  2. Early termination of a prospective, randomized trial comparing teicoplanin and flucloxacillin for treating severe staphylococcal infections. Calain, P., Krause, K.H., Vaudaux, P., Auckenthaler, R., Lew, D., Waldvogel, F., Hirschel, B. J. Infect. Dis. (1987) [Pubmed]
  3. Liver damage from flucloxacillin, cloxacillin and dicloxacillin. Olsson, R., Wiholm, B.E., Sand, C., Zettergren, L., Hultcrantz, R., Myrhed, M. J. Hepatol. (1992) [Pubmed]
  4. Ursodeoxycholic acid for the treatment of flucloxacillin-associated cholestasis. Piotrowicz, A., Polkey, M., Wilkinson, M. J. Hepatol. (1995) [Pubmed]
  5. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. Zimmerli, W., Widmer, A.F., Blatter, M., Frei, R., Ochsner, P.E. JAMA (1998) [Pubmed]
  6. Staphylococci surviving intracellularly in phagocytes from patients suffering from chronic granulomatous disease are killed in vitro by antibiotics encapsulated in liposomes. Roesler, J., Hockertz, S., Vogt, B., Lohmann-Matthes, M.L. J. Clin. Invest. (1991) [Pubmed]
  7. Rational choice of penicillins and cephalosporins based on parallel in-vitro and in-vivo tests. Selwyn, S. Lancet (1976) [Pubmed]
  8. Involvement of drug-specific T cells in acute drug-induced interstitial nephritis. Spanou, Z., Keller, M., Britschgi, M., Yawalkar, N., Fehr, T., Neuweiler, J., Gugger, M., Mohaupt, M., Pichler, W.J. J. Am. Soc. Nephrol. (2006) [Pubmed]
  9. Phlebitis induced by parenteral treatment with flucloxacillin and cloxacillin: a double-blind study. Svedhem, A., Alestig, K., Jertborn, M. Antimicrob. Agents Chemother. (1980) [Pubmed]
  10. Distribution of systemically administered ampicillin, benzylpenicillin, and flucloxacillin in excisional wounds in diabetic and normal rats and effects of local topical vasodilator treatment. Cross, S.E., Thompson, M.J., Roberts, M.S. Antimicrob. Agents Chemother. (1996) [Pubmed]
  11. Amikacin, ceftazidime, and flucloxacillin against suspended and adherent Pseudomonas aeruginosa and Staphylococcus epidermidis in an in vitro model of infection. Vergères, P., Blaser, J. J. Infect. Dis. (1992) [Pubmed]
  12. Effect of antibiotics eliminated by first order kinetics. Bergan, T., Carlsen, I.B. J. Antimicrob. Chemother. (1985) [Pubmed]
  13. Extravascular penetration of highly protein-bound flucloxacillin. Bergan, T., Engeset, A., Olszewski, W., Ostby, N., Solberg, R. Antimicrob. Agents Chemother. (1986) [Pubmed]
  14. Flucloxacillin concentration in serum and wound exudate during open heart surgery. Farrington, M., Fenn, A., Phillips, I. J. Antimicrob. Chemother. (1985) [Pubmed]
  15. Pharmacokinetics and bioavailability of flucloxacillin in elderly hospitalized patients. Gath, J., Charles, B., Sampson, J., Smithurst, B. Journal of clinical pharmacology. (1995) [Pubmed]
  16. Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research Database. Russmann, S., Kaye, J.A., Jick, S.S., Jick, H. British journal of clinical pharmacology. (2005) [Pubmed]
  17. Floxacillin-induced cholestatic hepatitis with evidence of lymphocyte sensitization. Victorino, R.M., Maria, V.A., Correia, A.P., de Moura, C. Arch. Intern. Med. (1987) [Pubmed]
  18. Concentrations of flucloxacillin in heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery. Frank, U., Schmidt-Eisenlohr, E., Schlosser, V., Spillner, G., Schindler, M., Daschner, F.D. Antimicrob. Agents Chemother. (1988) [Pubmed]
  19. Antibiotic-associated acute vanishing bile duct syndrome: a pattern associated with severe, prolonged, intrahepatic cholestasis. Davies, M.H., Harrison, R.F., Elias, E., Hübscher, S.G. J. Hepatol. (1994) [Pubmed]
  20. Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes. Lakehal, F., Dansette, P.M., Becquemont, L., Lasnier, E., Delelo, R., Balladur, P., Poupon, R., Beaune, P.H., Housset, C. Chem. Res. Toxicol. (2001) [Pubmed]
  21. Dicloxacillin and cloxacillin: pharmacokinetics in healthy and hemodialysis subjects. Nauta, E.H., Mattie, H. Clin. Pharmacol. Ther. (1976) [Pubmed]
  22. Cefotaxime and flucloxacillin as antibiotic prophylaxis in cardiac transplantation. Khaghani, A., Martin, M., Fitzgerald, M., Skacel, M., Aravot, D., Yacoub, M.H. Drugs (1988) [Pubmed]
  23. A multifaceted approach to the study of the side-chain conformation in beta-lactamase-resistant penicillins. Blanpain, P.C., Nagy, J.B., Laurent, G.H., Durant, F.V. J. Med. Chem. (1980) [Pubmed]
  24. Antibiotic prophylaxis in cardiac surgery: serum and tissue levels of teicoplanin, flucloxacillin and tobramycin. Wilson, A.P., Taylor, B., Treasure, T., Grüneberg, R.N., Patton, K., Felmingham, D., Sturridge, M.F. J. Antimicrob. Chemother. (1988) [Pubmed]
  25. Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin. Huwyler, J., Wright, M.B., Gutmann, H., Drewe, J. Curr. Drug Metab. (2006) [Pubmed]
  26. Properties of methicillin-resistant Staphylococcus aureus colonizing patients in a burns unit. Lacey, R.W., Barr, K.W., Barr, V.E., Inglis, T.J. J. Hosp. Infect. (1986) [Pubmed]
  27. Short-term adverse effects of antibiotic prophylaxis for open-heart surgery. Freeman, R. Thorax (1980) [Pubmed]
  28. Concentration of flucloxacillin in femoral head and joint capsule in total hip replacement. Pollard, J.P., Hughes, S.P., Evans, M.J., Scott, J.E., Benson, M.K. J. Antimicrob. Chemother. (1979) [Pubmed]
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