Disease relevance of RIMEXOLONE

• Reproductive toxicity studies in rats with rimexolone, a corticoid ophthalmic suspension [1].
• Rimexolone is a potent anti-inflammatory corticosteroid with a lower potential for elevating intraocular pressure, relative to other ophthalmic steroids, and is indicated for postsurgical inflammation and uveitis [1].
• In addition, a greater percentage of the rimexolone-treated patients had no conjunctival erythema on days 13 (11.1% vs 0.0%) and 20 (88.9% vs 55.6%) (P =.03) [2].
• PURPOSE: To evaluate the efficacy and safety of 1% rimexolone versus 1% prednisolone acetate ophthalmic suspension in the treatment of anterior uveitis [3].
• A high dose (up to 200 mg) tolerance and efficacy study of intra-articular rimexolone (Org 6216) in rheumatoid synovitis of the knee [4].

High impact information on RIMEXOLONE

• It would be desirable to monitor the intraocular pressure regularly when rimexolone therapy is used in children [2].
• Comparison of ketorolac tromethamine 0.5% and rimexolone 1% to control inflammation after cataract extraction. Prospective randomized double-masked study [5].
• However, there was no indication of a developmental effect on fetuses due to rimexolone [1].
• The mean residence time of rimexolone in the knee joint is very long and averaged 25 days [6].
• The pharmacokinetics of rimexolone were investigated after intra-articular injection into the knee joints of patients with rheumatoid arthritis [6].

Chemical compound and disease context of RIMEXOLONE

• Effect of topical dexamethasone versus rimexolone on middle ear inflammation in experimental otitis media with effusion [7].

Biological context of RIMEXOLONE

• Pharmacokinetics of rimexolone after intra-articular administration [6].
• Rimexolone showed linear kinetics [4].

Anatomical context of RIMEXOLONE

• RESULTS: When anterior chamber cell and flare were measured, rimexolone 1% was found to be as effective as 1% prednisolone [8].

Associations of RIMEXOLONE with other chemical compounds

• OBJECTIVE: To compare the intraocular pressure (IOP) elevating potential of 1.0% rimexolone and 0.1% fluorometholone alcohol ophthalmic suspensions in patients known to have responded to corticosteroids [9].
• Efficacy and safety of rimexolone 1% versus prednisolone acetate 1% in the control of postoperative inflammation following phacoemulsification cataract surgery [10].
• Both 1% rimexolone and 1% dexamethasone are effective in reducing the volume of middle ear effusion and mucosal thickness compared with control groups [7].
• Individual changes in adrenal response to ACTH and morning cortisol levels did not correlate with the dose or with serum levels of rimexolone [4].

Gene context of RIMEXOLONE

• The relative binding affinities (RBA) of two locally used glucocorticoids, rimexolone and flunisolide have been measured for the glucocorticoid receptor of human synovial tissue [11].

Analytical, diagnostic and therapeutic context of RIMEXOLONE

• Control of ocular inflammation after cataract extraction with rimexolone 1% ophthalmic suspension [12].
• AIM: A multicentre, randomized, placebo-controlled double-masked study was conducted to assess the efficacy and safety of Rimexolone 1% eye drops in reducing inflammation after cataract surgery and intra-ocular lens implantation [13].
• Intra-ocular pressure did not rise after treatment with Rimexolone 1% [13].
• Intra-articular rimexolone in the rheumatoid knee: a placebo-controlled, double-blind, multicentre trial of three doses [14].

References