Disease relevance of prednisolone acetate

• Symptoms and signs improved after cessation of the drug therapy and administration of prednisolone acetate [1].
• All patients received fluocortolone 1 mg/kg body weight per day, tapered over 3 weeks, and topical prednisolone acetate 1%, tapered over 5 months [2].
• Frequent topical administration of 1.0% prednisolone acetate during the first 100 hours of the experimental anterior uveitis produced a significant decrease both in protein and in the number of leukocytes in the anterior chamber [3].
• The biomicroscopic appearance of the cataracts, which was quite similar to that of human eyes, was induced by daily application, either topically or systemically, of prednisolone acetate for 12 months [4].
• Radiation-induced myeloid leukemia in C3H/He mice and the effect of prednisolone acetate on leukemogenesis [5].

High impact information on prednisolone acetate

• Similarly, in nonleukopenic rabbits, topical therapy with 1% prednisolone acetate markedly reduced the corneal inflammatory response which also was characterized by fewer invading leukocytes [6].
• A comparison was made of the effects of topically applied cyclosporine, and topically applied prednisolone acetate, on the prolongation of corneal allograft survival in a recently developed prevascularized rabbit eye model [7].
• A prospective study of the long-term efficacy of local methyl prednisolone acetate injection in the management of mild carpal tunnel syndrome [8].
• OBJECTIVES: To compare the effectiveness of a steroid injection (25 mg/ml prednisolone acetate) with a local anaesthetic control in the treatment of heel pain and to determine any advantage for patients' comfort of using a posterior tibial nerve block to anesthetize the heel prior to infiltration [9].
• Plasma steroid levels after intra-articular injection of prednisolone acetate in patients with rheumatoid arthritis [10].

Chemical compound and disease context of prednisolone acetate

• In the subacute ear edema bioassay, the conjugates displayed no discernible untoward systemic effects, unlike prednisolone and prednisolone acetate, which elicited significant adverse systemic effects, at equipotent doses [11].
• Methyl prednisolone acetate caused the most severe recrudescence of microfilariae while cyclophosphamide caused a low level, transient microfilaremia [12].
• Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis [13].
• After 6 weeks, inhibition of corneal neovascularization was found with flurbiprofen (p = 0.001), while there was a trend toward inhibition of corneal neovascularization with prednisolone acetate (p = 0.076) [14].
• Intra-articular treatment of knee osteoarthritis. A comparative study between hyaluronic acid and 6-methyl prednisolone acetate [15].

Biological context of prednisolone acetate

• We investigated the in vitro ocular bioavailability of several marketed ophthalmic drug formulations using this model (0.03% flurbiprofen, 0.5% levobunolol, 0.1 and 0.25% fluorometholone, and 1% prednisolone acetate) [16].
• METHODS: Intraocular pressure was monitored by Perkins applanation tonometry in a group of 12 cows receiving topically administered prednisolone acetate in 1 eye 3 times a day for a period of 49 days after the establishment of baseline IOP values [17].
• Eyes developing stage 3 DLK or at risk for progressing to stage 3 were treated with a combination of high-dose prednisolone acetate 1% and oral prednisone and evaluated for corneal scarring, loss of best spectacle-corrected visual acuity (BSCVA), and deviation from the intended refractive outcome [18].
• The use of topical prednisolone acetate during the postoperative period may also contribute to dellen formation by inhibiting corneal epithelial wound healing [19].
• In this animal study fluorometholone prevented immune graft rejection in a percentage similar to that of prednisolone acetate and dexamethasone phosphate [20].

Anatomical context of prednisolone acetate

• Early appearance and mitotic activity of multinucleated giant cells in mice after combined injection of talc and prednisolone acetate. A model for studying rapid histiocytic polykarion formation in vivo [21].
• Eight patients with rheumatoid arthritis received an intra-articular injection of either 50 mg or 100 mg of prednisolone acetate into the knee joint [10].
• First, the level that varying concentrations of topically administered prednisolone acetate attained in the cornea and aqueous humor was determined [22].
• Effect of ophthalmic prednisolone acetate on the canine adrenal gland and hepatic function [23].
• The results also suggest that prednisolone acetate may exert oestrogen-like actions on cervical mucus [24].

Associations of prednisolone acetate with other chemical compounds

• PURPOSE: The effect of ultrasound on skin penetration and metabolism of prednisolone (PN) and prednisolone 21-acetate (PNA) was investigated in the hairless mouse skin in vitro [25].
• OBJECTIVE: To determine whether a topical ophthalmic diclofenac sodium formulation containing a proprietary polymeric drug delivery system (ISV-205), when dosed concomitantly with 1% prednisolone acetate, is effective in blocking the intraocular pressure (IOP) response in humans [26].
• Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions [27].
• After treatment with prednisolone acetate 1% and topical cyclosporin A 0.5%, the DLK resolved in both eyes with residual faint, diffuse, corneal haze [28].
• A high-performance liquid chromatographic (HPLC) method for the simultaneous determination of prednisolone acetate (PA), prednisolone (PO), prednisone (PN), cortisone and hydrocortisone in swine plasma is described [29].

Gene context of prednisolone acetate

• We investigated the hydrolytic activity of prednisolone 21-acetate (PNA) to prednisolone (PN) in an enzyme solution composed of esterase and skin homogenates from hairless mice [30].
• METHODS: A murine model of P. aeruginosa keratitis was used to compare the response to ofloxacin, tobramycin, prednisolone acetate, and non-preserved saline treatment, as well as combination antibiotic-corticosteroid therapy for infection caused by a cytotoxic strain (6206) and an invasive strain (PAO1) [31].
• PURPOSE: This study was conducted to evaluate the efficacy of two topical steroid prednisolone preparations (Econopred Plus 1%, prednisolone acetate 1%: EPP; Pred Fortedagger 1%, prednisolone acetate 1%: PF) in reducing postoperative inflammation in cataract patients [32].

Analytical, diagnostic and therapeutic context of prednisolone acetate

• Combined intraperitoneal injection of talc and particulate prednisolone acetate resulted in the formation of significant numbers of multinucleated giant cells within 48 hours [21].
• Topical administration of 6.5 mg of prednisolone acetate over a 30-hour period reduced corneal inflammatory activity by 52% [33].
• Six patients were fitted early after keratoplasty, ie, before the removal of the sutures and while they were still receiving corticosteroid drops (1% prednisolone acetate) [34].
• Microspheres containing methylene blue and prednisolone acetate were prepared by one of three methods: freeze-drying, evaporation, and solvent-extraction-precipitation [35].
• We used an animal model to compare the corneal and aqueous penetration of topical prednisolone acetate 1% with and without the presence of a commercially available collagen corneal shield [36].

References