Disease relevance of fluorometholone

• Therapeutic effectiveness of fluorometholone in inflammatory keratitis [1].
• AIMS: To compare the efficacy of topical nedocromil 2% with fluorometholone 0.1% in vernal keratoconjunctivitis (VKC) [2].
• Regarding the seasonal study, 96 patients with active SAC were treated bilaterally with either desonide or fluorometholone for 3 weeks, and allergic signs and symptoms evaluated at regular intervals [3].
• METHODS: In this multicenter, double-masked, randomized, placebo-controlled, parallel comparison study, 140 chronic open-angle glaucoma patients received either 0.25% fluorometholone or vehicle four times a day unilaterally, beginning 24 hours before and continuing one week after argon laser trabeculoplasty [4].
• Seasonal study: desonide and fluorometholone were both highly effective in reducing itching, tearing, and conjunctival hyperemia over time (p < 0.0001) [3].

High impact information on fluorometholone

• CONCLUSIONS: These data suggest that diclofenac and fluorometholone may influence corneal wound healing in rabbits after excimer laser PRK and support a potential role for using topical nonsteroidal anti-inflammatory drugs in preventing the development of excessive corneal haze after excimer laser surgery [5].
• After the epithelium healed, dexamethasone was applied 4 times a day during the first postoperative week and then fluorometholone was applied 4 times a day for a minimum of 4 weeks [6].
• Hourly topical administration of 0.1% fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis [7].
• Fluorometholone readily penetrates the intact corneal epithelium and accumulates in the hydrophilic stromal layers of the cornea [8].
• In age-, race-, and sex-matched groups, the relative abilities of medrysone, fluorometholone, and dexamethasone phosphate to elevate intraocular pressure were compared in a masked manner [9].

Chemical compound and disease context of fluorometholone

• CONCLUSIONS: Treatment of an experimental ocular adenovirus infection with PA, FM, and RMX for 3 days significantly enhanced adenovirus replication compared with the control group [10].
• Comparison of diclofenac and fluorometholone in preventing cystoid macular edema after small incision cataract surgery: a multicentered prospective trial [11].
• This case highlights an isolated limbal nodule as an unusual presentation of vernal keratoconjunctivitis that did not respond to topical fluorometholone (0.1%), but resolved with topical cyclosporine (2%) [12].
• Method: In two separate prospective, randomised, group-controlled studies, topical fluorometholone 0.1% (FML Liquifilm) was compared with dexamethasone 0.1% (Maxidex) (Study A), or naphazoline hydrochloride 0.1% (Albalon) (Study B) after ALT for chronic open-angle glaucoma, with particular reference to the formation of PAS and the IOP response [13].

Biological context of fluorometholone

• Intraocular pressure response to topically administered fluorometholone [14].
• Vehicle effects on ocular drug bioavailability i: evaluation of fluorometholone [15].
• ETM cell density was significantly decreased in case of preoperative fluorometholone instillation [16].
• The results for fluorometholone acetate show that the combination product is 15 per cent higher in AUC for the cornea than the single-entity product (0.05 less than p less than 0.1) [17].
• The purpose of this study is to investigate the effects of antibiotics and glucocorticoid eyedrops, including gentamicin, sulfisomezole, fluorometholone, dexamethasone, and betamethasone, on cellular proliferation in cultured human corneal keratocytes [18].

Anatomical context of fluorometholone

• Penetration of fluorometholone into the cornea and aqueous humor [19].
• During an experimentally-induced inflammatory keratitis, we measured the ability of 0.1% fluorometholone ophthalmic suspension to reduce the numbers of polymorphonuclear leukocytes that invaded the cornea [1].
• RESULTS: Following argon laser trabeculoplasty, signs of anterior chamber inflammation were significantly lower in the fluorometholone group [4].
• The number of PMNs in the corneal stroma was significantly higher after photorefractive keratectomy than after deepithelialization alone (P = .001) and than in normal unoperated corneas; fluorometholone treatment significantly reduced PMN accumulation (P = .001) [20].

Associations of fluorometholone with other chemical compounds

• Rejection occurred in eight of nine rabbits in the control group; one of eight in the dexamethasone phosphate group; one of eight in the fluorometholone group; and one of ten in the prednisolone acetate group [21].
• LTC4 levels were also significantly reduced after treatment in all three treatment groups (for the lodoxamide group, p = 0.0209; for the DCG group, p = 0.0284; for the fluorometholone group, p = 0.0109) [22].
• Tetrahydrotriamcinolone 0.25% and fluorometholone 0.05 and 0.01% failed to elevate intraocular pressure significantly [23].
• After treatment, LTB4 levels decreased significantly in all treatment groups when compared with baseline (for the lodoxamide group, p = 0.01; for the DCG group, p = 0.008; for the fluorometholone group, p = 0.045) [22].
• RESULTS: Compared with the control group, treatment with PA, FM, and RMX significantly increased the number of Ad5 positive eye cultures from days 7-21 [10].

Analytical, diagnostic and therapeutic context of fluorometholone

• In each of the experimental conditions studied, fluorometholone penetrated into the cornea and aqueous humor following topical administration of a standard drop [19].
• RESULTS: There were no statistically significant differences in the success rate of argon laser trabeculoplasty between the fluorometholone and control groups over the follow-up period of 4.6 +/- 3.4 years [24].
• Fluorometholone-induced cataract after photorefractive keratectomy [25].
• Comparison of topical prednisolone acetate, ketorolac tromethamine and fluorometholone acetate in reducing inflammation after phacoemulsification [26].
• It is generally accepted that fluorometholone is not as potent an anti-inflammatory as prednisolone the most commonly used steroid following cataract extraction [27].

References