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Chemical Compound Review

Dicetel     4-[(2-bromo-4,5-dimethoxy- phenyl)methyl]-4...

Synonyms: LAT-1717, AG-B-43436, CHEMBL1909298, LAT 1717, CTK8G2430, ...
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Disease relevance of Pinaverium

 

Psychiatry related information on Pinaverium

 

High impact information on Pinaverium

 

Biological context of Pinaverium

 

Anatomical context of Pinaverium

 

Associations of Pinaverium with other chemical compounds

 

Gene context of Pinaverium

  • The inhibition of postprandial colonic motility by pinaverium bromide, given orally at therapeutic doses, involves a CCK-dependent pathway which requires the integrity of capsaicin-sensitive afferents [13].
 

Analytical, diagnostic and therapeutic context of Pinaverium

References

  1. Effects of oral pinaverium bromide on colonic response to food in irritable bowel syndrome patients. Bouchoucha, M., Faye, A., Devroede, G., Arsac, M. Biomed. Pharmacother. (2000) [Pubmed]
  2. Effects of pinaverium bromide in the premedication of endoscopic retrograde cholangio-pancreatography and on motor activity of the sphincter of Oddi. Lamazza, A., Tofi, A., Bolognese, A., Fontana, B., De Masi, E., Frontespezi, S. Current medical research and opinion. (1986) [Pubmed]
  3. Effectiveness of pinaverium bromide in the treatment of primitive biliary dyskinesia: 99mTc-P-IDA scintigraphic evaluation. Scaffidi, A., Costa, R., Frontespezi, S. International journal of clinical pharmacology, therapy, and toxicology. (1987) [Pubmed]
  4. Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Evangelista, S. Curr. Pharm. Des. (2004) [Pubmed]
  5. Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide. Boyer, J.C., Magous, R., Christen, M.O., Balmes, J.L., Bali, J.P. Cell Calcium (2001) [Pubmed]
  6. Effects of pinaverium bromide on Oddi's sphincter. DiSomma, C., Reboa, G., Patrone, M.G., Mortola, G.P., Sala, G., Ciampini, M. Clinical therapeutics. (1986) [Pubmed]
  7. Action of pinaverium bromide on calmodulin-regulated functions. Wuytack, F., De Schutter, G., Casteels, R. Eur. J. Pharmacol. (1985) [Pubmed]
  8. Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle. Feron, O., Wibo, M., Christen, M.O., Godfraind, T. Br. J. Pharmacol. (1992) [Pubmed]
  9. Comparison of pinaverium bromide, manganese chloride and D600 effects on electrical and mechanical activities in rat uterine smooth muscle. Mironneau, J., Lalanne, C., Mironneau, C., Savineau, J.P., Lavie, J.L. Eur. J. Pharmacol. (1984) [Pubmed]
  10. Investigation of drug interactions with pinaverium bromide. Devred, C., Godeau, P., Guerot, C., Librez, P., Mougeot, G., Orsetti, A., Segrestaa, J.M. Current medical research and opinion. (1986) [Pubmed]
  11. Action of pinaverium bromide, a calcium-antagonist, on gastrointestinal motility disorders. Christen, M.O. Gen. Pharmacol. (1990) [Pubmed]
  12. Effects of pinaverium bromide and verapamil on the motility of the rat isolated colon. Baumgartner, A., Drack, E., Halter, F., Scheurer, U. Br. J. Pharmacol. (1985) [Pubmed]
  13. Involvement of a CCK-dependent capsaicin-sensitive afferent pathway in the inhibitory effect of pinaverium bromide on the colonic motor response to eating in rats. Fioramonti, J., Christen, M.O., Dupre, I., Bueno, L. Fundamental & clinical pharmacology. (1997) [Pubmed]
  14. Motor effects of locally administered pinaverium bromide in the sigmoid tract of patients with irritable bowel syndrome. Passaretti, S., Sorghi, M., Colombo, E., Mazzotti, G., Tittobello, A., Guslandi, M. International journal of clinical pharmacology, therapy, and toxicology. (1989) [Pubmed]
  15. Electrophysiological study of intravenous pinaverium bromide in cardiology. Guerot, C., Khemache, A., Sebbah, J., Noel, B. Current medical research and opinion. (1988) [Pubmed]
 
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