The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

GW0072     4-[4-[(2S,5S)-5- (dibenzylcarbamoylmethyl)...

Synonyms: AC1L9N85, 4prg, 173188-EP2285796A1, thiazolidinone (GW0072)
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GW0072


High impact information on GW0072


Biological context of GW0072


Anatomical context of GW0072

  • Recently a new anion channel inhibitor, a thiazolidinone derivative, termed CFTRInh-172 has been synthesized and introduced with apparently improved inhibitory properties as shown by effects on anion conductance expressed in cell lines and on secretion in vivo [6].
  • Thiazolidinone congeners as central nervous system active agents [7].

Associations of GW0072 with other chemical compounds


Gene context of GW0072

  • Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker [12].
  • We used the selective thiazolidinone CFTR inhibitor CFTR(inh)-172 to define the involvement of CFTR in nasal PD changes in mice and pigs [13].
  • By screening unbiased combinatorial chemistry libraries, using a cAMP-responsive luciferase reporter assay, we discovered thiazolidinone agonists (EC(50's) = 20 mum) of the human FSH-R [14].
  • Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives [15].

Analytical, diagnostic and therapeutic context of GW0072

  • The compounds VIg-l have two chiral centers in each thiazolidinone moiety so two diastereomers are possible, but on crystallization and repeated chromatography, one diastereomer was obtained [16].


  1. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. Ma, T., Thiagarajah, J.R., Yang, H., Sonawane, N.D., Folli, C., Galietta, L.J., Verkman, A.S. J. Clin. Invest. (2002) [Pubmed]
  2. Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. Thiagarajah, J.R., Broadbent, T., Hsieh, E., Verkman, A.S. Gastroenterology (2004) [Pubmed]
  3. Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants. Scheible, W.R., Eshed, R., Richmond, T., Delmer, D., Somerville, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. Oberfield, J.L., Collins, J.L., Holmes, C.P., Goreham, D.M., Cooper, J.P., Cobb, J.E., Lenhard, J.M., Hull-Ryde, E.A., Mohr, C.P., Blanchard, S.G., Parks, D.J., Moore, L.B., Lehmann, J.M., Plunket, K., Miller, A.B., Milburn, M.V., Kliewer, S.A., Willson, T.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 2. Structure-activity relationships of thiazolidinone derivatives. Kato, T., Ozaki, T., Tamura, K., Suzuki, Y., Akima, M., Ohi, N. J. Med. Chem. (1999) [Pubmed]
  6. Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts. Wang, X.F., Reddy, M.M., Quinton, P.M. Exp. Physiol. (2004) [Pubmed]
  7. Thiazolidinone congeners as central nervous system active agents. Tripathi, M., Verma, M., Gujrati, V.R., Palit, G., Shanker, K. Arzneimittel-Forschung. (1993) [Pubmed]
  8. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Lecka-Czernik, B., Moerman, E.J., Grant, D.F., Lehmann, J.M., Manolagas, S.C., Jilka, R.L. Endocrinology (2002) [Pubmed]
  9. CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Verkman, A.S., Lukacs, G.L., Galietta, L.J. Curr. Pharm. Des. (2006) [Pubmed]
  10. Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. Fischer, W., Bodewei, R., Satzinger, G. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  11. Microwave assisted synthesis of fragrant jasmone heterocyclic analogues. Pawełczyk, A., Zaprutko, L. European journal of medicinal chemistry. (2006) [Pubmed]
  12. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. Taddei, A., Folli, C., Zegarra-Moran, O., Fanen, P., Verkman, A.S., Galietta, L.J. FEBS Lett. (2004) [Pubmed]
  13. CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. Salinas, D.B., Pedemonte, N., Muanprasat, C., Finkbeiner, W.F., Nielson, D.W., Verkman, A.S. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  14. Allosteric Activation of the Follicle-stimulating Hormone (FSH) Receptor by Selective, Nonpeptide Agonists. Yanofsky, S.D., Shen, E.S., Holden, F., Whitehorn, E., Aguilar, B., Tate, E., Holmes, C.P., Scheuerman, R., Maclean, D., Wu, M.M., Frail, D.E., López, F.J., Winneker, R., Arey, B.J., Barrett, R.W. J. Biol. Chem. (2006) [Pubmed]
  15. Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives. Shih, M.H., Ke, F.Y. Bioorg. Med. Chem. (2004) [Pubmed]
  16. Synthesis and fungicidal activity of novel 4,4'-bis(2' '-aryl-5' '-methyl/unsubstituted-4' '-oxo-thiazolidin-3' '-yl) bibenzyl. Siddiqui, I.R., Singh, P.K., Singh, J., Singh, J. J. Agric. Food Chem. (2003) [Pubmed]
WikiGenes - Universities