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Chemical Compound Review

Dipiperal     1-[4-(4-fluorophenyl)-4-oxo- butyl]-4-(1...

Synonyms: Dipiperon, Piperonil, Piperonyl, Dipiperone, Pipamperona, ...
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Disease relevance of Dipiperal


Psychiatry related information on Dipiperal


High impact information on Dipiperal


Biological context of Dipiperal


Anatomical context of Dipiperal


Associations of Dipiperal with other chemical compounds


Gene context of Dipiperal

  • The electrochemical reduction of pipamperone has been carried out in aqueous solution in KNO(3) (0.1 mol l(-1)) by differential-pulse polarography (DPP) [20].
  • A sensitive and reproducible high performance liquid chromatographic method was developed for the determination of pipamperone (1'-[4-(4-fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'- carboxamide, Dipiperon, CAS 1893-33-0) in plasma samples [21].

Analytical, diagnostic and therapeutic context of Dipiperal


  1. Response to pipamperone in case of epidermolysis bullosa herpetiformis. Bonnetblanc, J.M., Bouquier, J.J. Lancet (1986) [Pubmed]
  2. Hypothermia induced by atypical neuroleptics. Schwaninger, M., Weisbrod, M., Schwab, S., Schröder, M., Hacke, W. Clinical neuropharmacology. (1998) [Pubmed]
  3. Torsade de pointes after pipamperone intoxication. Bont, L., Bosker, H.A., Brus, F., Yska, J.P., Bosch, F.H. Pharmacy world & science : PWS. (1998) [Pubmed]
  4. Toxicity of synthetic piperonyl compounds to leaf-cutting ants and their symbiotic fungus. Victor, S.R., Crisóstomo, F.R., Bueno, F.C., Pagnocca, F.C., Fernandes, J.B., Correa, A.G., Bueno, O.C., Hebling, M.J., Bacci Júnior, M., Vieira, P.C., da Silva, M.F. Pest Manag. Sci. (2001) [Pubmed]
  5. Effects of dopamine antagonists on retinal B-wave recovery after retinal ischemia. Chiou, G.C., Li, B.H. Journal of ocular pharmacology. (1993) [Pubmed]
  6. Sleep disorders in patients with severe mental depression: double-blind placebo-controlled evaluation of the value of pipamperone (Dipiperon). Ansoms, C., Backer-Dierick, G.D., Vereecken, J.L. Acta psychiatrica Scandinavica. (1977) [Pubmed]
  7. Syntheses and specific activity determinations of no-carrier-added (NCA) F-18-labeled butyrophenone neuroleptics--benperidol, haloperidol, spiroperidol, and pipamperone. Shiue, C.Y., Fowler, J.S., Wolf, A.P., Watanabe, M., Arnett, C.D. J. Nucl. Med. (1985) [Pubmed]
  8. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Schotte, A., Janssen, P.F., Gommeren, W., Luyten, W.H., Van Gompel, P., Lesage, A.S., De Loore, K., Leysen, J.E. Psychopharmacology (Berl.) (1996) [Pubmed]
  9. Selective 5-hydroxytryptamine2 antagonists have antidepressant-like effects on differential-reinforcement-of-low-rate 72-second schedule. Marek, G.J., Li, A.A., Seiden, L.S. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  10. Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. Oekelen, D.V., Jurzak, M., Van de Wiel, D., Van Hecke, G., Luyten, W.H., Leysen, J.E. Eur. J. Pharmacol. (2001) [Pubmed]
  11. Esterase inhibition and reactivation in relation to piperonyl butoxide-phosphorothionate interactions. Levine, B.S., Murphy, S.D. Toxicol. Appl. Pharmacol. (1977) [Pubmed]
  12. Pharmacokinetics of pipamperone from three different tablet formulations. Potgieter, G.E., Groenewoud, G., Jordaan, P.J., Hundt, H.K., Schall, R., Kummer, M., Sewarte-Ross, G. Arzneimittel-Forschung. (2002) [Pubmed]
  13. Effects of dopamine agonist, bromocriptine, and some dopamine antagonists on ocular blood flow. Chiou, G.C., Chen, Y.J. Journal of ocular pharmacology. (1992) [Pubmed]
  14. Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone. Janssen, P.A., Awouters, F.H. Arzneimittel-Forschung. (1994) [Pubmed]
  15. Two mechanisms of CCl4-induced fatty liver: lipid peroxidation or covalent binding studied in cultured rat hepatocytes. Becker, E., Messner, B., Berndt, J. Free Radic. Res. Commun. (1987) [Pubmed]
  16. Identification of a high-affinity binding site for dinotefuran in the nerve cord of the American cockroach. Miyagi, S., Komaki, I., Ozoe, Y. Pest Manag. Sci. (2006) [Pubmed]
  17. The effects of dexetimide on pimozide-, haloperidol- and pipamperone-induced inhibition of brain self-stimulation in rats. Wauquier, A., Niemegeers, C.J. Archives internationales de pharmacodynamie et de thérapie. (1975) [Pubmed]
  18. Preliminary evidence of the role of hydrogen peroxide in the degradation of benzo[a]pyrene by a non-white rot fungus Fusarium solani. Veignie, E., Rafin, C., Woisel, P., Cazier, F. Environ. Pollut. (2004) [Pubmed]
  19. Analyses of butyrophenones and their analogues in whole blood by high-performance liquid chromatography-electrospray tandem mass spectrometry. Seno, H., Hattori, H., Ishii, A., Kumazawa, T., Watanabe-Suzuki, K., Suzuki, O. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  20. Differential-pulse polarography determination of pipamperone in pharmaceutical formulations. Belgaied, J.E., Trabelsi, H. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  21. Determination of pipamperone in human plasma by high performance liquid chromatography. Luhmann, I., Szathmary, S.C., Grünert, I. Arzneimittel-Forschung. (1992) [Pubmed]
  22. Mass spectral characterization of urinary pipamperone metabolites and high-performance liquid chromatography assay for pipamperone plasma levels. Köppel, C., Tenczer, J., Wagemann, A. J. Chromatogr. (1989) [Pubmed]
  23. Pipamperone (Dipiperon, R3345) in troublesome mental retardates: a double-blind placebo controlled cross-over study with long-term follow-up. van Hemert, J.C. Acta psychiatrica Scandinavica. (1975) [Pubmed]
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