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Chemical Compound Review

AC1LAVIK     11-hydroxy-17-(2- hydroxyethanoyl)-10...

Synonyms: NCIOpen2_008650
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Disease relevance of ALDOSTERONE


High impact information on ALDOSTERONE

  • The present study demonstrates that the undisturbed human fetus at 16-20 weeks gestation actively secretes the most important gluco- and mineralocorticoids, F, B, and Aldo, independent of the mother [3].
  • Plasma cortisol alters the distribution of aldo between red blood cells (RBC) and plasma [4].
  • We postulated that the distribution of 18-OH-B, like that of aldo, is determined by the availability of high affinity binding sites on plasma transcortin [4].
  • We recently demonstrated that the enhanced renal conservation of sodium and water in rats with heart failure can be reduced by blocking the central nervous system effects of Aldo with the mineralocorticoid receptor (MR) antagonist spironolactone (SL) [5].
  • The Randomized Aldactone Evaluation Study (RALES) demonstrated a substantial clinical benefit to blocking the effects of aldosterone (Aldo) in patients with heart failure [5].

Biological context of ALDOSTERONE


Anatomical context of ALDOSTERONE

  • The corresponding transcript of this ovine P450(11 beta) cDNA was located throughout the adrenal cortex and thus the inability of the zonae fasciculata-reticularis to secrete ALDO remains to be understood [10].

Associations of ALDOSTERONE with other chemical compounds

  • This study tested the effects of hypothalamic as well as extrahypothalamic implants of the adrenal steroids, corticosterone (CORT) and aldosterone (ALDO), on food intake and macronutrient selection in sham-operated and adrenalectomized (ADX) rats 1 h after administration [6].
  • DEX effectively increased V1a receptor binding site density whereas ALDO had no effect [11].
  • 3. Plasma NE, E, ANP, and ATII responses were comparable between male and female subjects, but PRA both at rest and during exercise and ALD at rest were significantly higher in male subjects [12].
  • In vivo studies revealed that the plasma level of Aldo was high, but those of the other steroid hormones were within the normal range [13].
  • The mean values (nmol/24 h) of reference ranges established from 32 normal males were as follows: P: 0.36; AD: 9.76; PL: 0.90; DHT: 0.61; DHEA: 6.76; T: 1.43; DOC: 0.35; 17-OHP: 1.03; 17-PL: 0.20; S: 0.24; 18-OH-DOC: 2.11; B: 1.49; Aldo: 0.46; F: 68.3; 18-OH-B: 5.41 [14].

Gene context of ALDOSTERONE

  • ALDO replacement also elevated V1aR binding in the BNST but not in the septum [15].
  • In 9 of 10 subjects, ALDO was acutely lowered (p < 0.009) suggesting that ANG II levels were incompletely blocked by CEI [16].
  • ALDO increased fivefold (P less than 0.05), but AVP did not change [9].
  • 4. Cardiac responses to submaximal exercise were different between male and female subjects, but neurohormonal responses were comparable between the two groups except for the high PRA at rest and during exercise and high plasma ALD at rest in male subjects [12].
  • Hormone analyses included atrial natriuretic peptide (ANP), aldosterone (ALDO), and plasma renin activity (PRA) [17].


  1. Adrenocortical steroid requirements for initiation of ACTH-dependent hypertension in sheep. Spence, C.D., Coghlan, J.P., Denton, D.A., Mills, E.H., Whitworth, J.A., Scoggins, B.A. Clin. Exp. Pharmacol. Physiol. (1989) [Pubmed]
  2. Aminoglutethimide effect on circadian rhythms in urinary variables in a patient with idiopathic hyperaldosteronism. Muratani, H., Ueno, M., Kawasaki, T., Abe, I., Kawazoe, N., Omae, T. Chronobiologia. (1985) [Pubmed]
  3. The steroid hormonal milieu of the undisturbed human fetus and mother at 16-20 weeks gestation. Partsch, C.J., Sippell, W.G., MacKenzie, I.Z., Aynsley-Green, A. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  4. Distribution of 18-hydroxycorticosterone between red blood cells and plasma. Zager, P.G., Frey, H.J., Spalding, C.T., Wengs, W.J., Brittenham, M.C. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  5. Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats. Francis, J., Weiss, R.M., Johnson, A.K., Felder, R.B. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  6. The paraventricular nucleus is uniquely responsive to the feeding stimulatory effects of steroid hormones. Tempel, D.L., Kim, T., Leibowitz, S.F. Brain Res. (1993) [Pubmed]
  7. Effects of amlodipine on renal haemodynamics in mild to moderate hypertensive patients. A randomized controlled study versus placebo. Licata, G., Scaglione, R., Ganguzza, A., Parrinello, G., Costa, R., Merlino, G., Corrao, S., Amato, P. Eur. J. Clin. Pharmacol. (1993) [Pubmed]
  8. Influences of sex and saline intake on diurnal changes in plasma melatonin and osmoregulatory hormones of Pekin ducks (Anas platyrhynchos). Hughes, M.R., Bennett, D.C., Gray, D.A., Sharp, P.J., Poon, A.M. Gen. Comp. Endocrinol. (2006) [Pubmed]
  9. Cardiovascular and endocrine responses to head-up tilt and vasopressin infusion in humans. Bie, P., Secher, N.H., Astrup, A., Warberg, J. Am. J. Physiol. (1986) [Pubmed]
  10. Functional and expression analysis of ovine steroid 11 beta-hydroxylase (cytochrome P450 11 beta). Boon, W.C., Roche, P.J., Butkus, A., McDougall, J.G., Jeyaseelan, K., Coghlan, J.P. Endocr. Res. (1997) [Pubmed]
  11. Evidence for glucocorticoid regulation of the rat vasopressin V1a receptor gene. Watters, J.J., Swank, M.W., Wilkinson, C.W., Dorsa, D.M. Peptides (1996) [Pubmed]
  12. Responses of catecholamines, renin-angiotensin system, and atrial natriuretic peptide to exercise in untrained men and women. Kinugawa, T., Ogino, K., Miyakoda, H., Saitoh, M., Hisatome, I., Fujimoto, Y., Yoshida, A., Shigemasa, C., Sato, R. Gen. Pharmacol. (1997) [Pubmed]
  13. In vivo and in vitro studies on steroid metabolism in a case of primary aldosteronism with multiple lesions of adenoma and nodular hyperplasia. Honda, M., Tsuchiya, M., Tamura, H., Watanabe, H., Izumi, Y., Hatano, M., Shiratsuchi, T., Den, K., Kawaoi, A., Okano, T. Endocrinol. Jpn. (1982) [Pubmed]
  14. Specific estimation of fifteen unconjugated, non-metabolized steroid hormones in human urine. Schöneshöfer, M., Weber, B. J. Steroid Biochem. (1983) [Pubmed]
  15. Glucocorticoid regulation of vasopressin V1a receptors in rat forebrain. Watters, J.J., Wilkinson, C.W., Dorsa, D.M. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  16. Combined converting enzyme inhibition and angiotensin receptor blockade reduce proteinuria greater than converting enzyme inhibition alone: insights into mechanism. Panos, J., Michelis, M.F., DeVita, M.V., Lavie, R.H., Wilkes, B.M. Clin. Nephrol. (2003) [Pubmed]
  17. Body fluid regulation in a simulated disabled submarine: effects of cold, reduced O2, and elevated CO2. Castellani, J.W., Francis, J.R., Stulz, D.A., DeLany, J.P., Hoyt, R.W., Bovill, M.E., Young, A.J. Aviation, space, and environmental medicine. (2005) [Pubmed]
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