Disease relevance of Renal Blood Flow, Effective

• During hypotension, urine flow rate, effective renal blood flow, endogenous creatinine clearance, and osmolar clearance decreased [1].
• In addition to its hypotensive effects bunazosin significantly increased the effective renal blood flow (by 34%) and creatinine clearance (by 37%) in patients with essential hypertension [2].

High impact information on Renal Blood Flow, Effective

• TAK-044 also reduced MAP (by up to 11+/-3%) and increased effective renal blood flow in the contralateral kidney (by up to 46+/-27%) [3].
• In contrast, ERBF dose dependently suppressed IL-6-induced neuronal differentiation in PC-12 cells [4].
• ERBF did not affect IL-2-dependent growth of CTLL-2 cells, IL-3-dependent growth of Baf3 cells, or tumor necrosis factor (TNF)alpha-induced growth suppression in TNFalpha-sensitive L929 cells [4].
• ERBF also did not affect IL-4-stimulated expression of FcepsilonR II receptor (CD23) in U-937 cells, the IL-8-induced chemotaxis of human neutrophils, or nerve growth factor-stimulated neuronal differentiation in PC-12 cells [4].
• These results clearly indicate that ERBF is a novel specific small molecule to show IL-6 receptor antagonist activity [4].

Biological context of Renal Blood Flow, Effective

• Glomerular filtration rate was measured by inulin clearance and effective renal blood flow was measured by para-amino hippurate clearance [5].
• Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses [6].
• When compared to control lambs, both indomethacin doses reduced effective renal blood flow significantly at 2--4 h, but only high doses significantly reduced renal blood flow at 22--24 h (6.5 +/- 0.9 vs. 13.4 +/- 1.4 ml/min/kg, respectively; p less than 0.001) [7].
• Eighteen hours later, thermodilution cardiac output, mean arterial pressure, heart rate, hematocrit, EHBF by galactose clearance, and ERBF by p-aminohippurate (PAH) clearance were determined [8].

Anatomical context of Renal Blood Flow, Effective

• When synthetic vasopressin was given by osmotic minipumps for 10 days, with the rats gaining weight and thus changing the volume of their body fluids, GFR and ERBF increased significantly, by approximately 45 and 55%, respectively [9].

Associations of Renal Blood Flow, Effective with chemical compounds

• In the course of a screening program aimed at IL-6 inhibitor from natural products, we isolated 20S,21-epoxy-resibufogenin-3-formate (ERBF) from bufadienolide and examined the effect of ERBF on activities of various cytokines [4].
• In healthy volunteers the mean difference in GFR was 4.8 ml min-1 (95% CI -8.2 to 17.7 ml min-1) and the mean difference in ERBF was 49.8 ml min-1 (95% CI -47.5 to 147 ml min-1) after celiprolol [10].
• Nadolol reduced mean arterial pressure from 133.2 +/- 2.0 to 113.5 +/- 3 mm Hg (P less than 0.001) but reduced mean effective renal blood flow from 558.8 +/- 32.2 to 446.0 +/- 26.9 ml min-1 1.73 m-2 (P less than 0.05) [11].
• Atenolol lowered mean arterial pressure (mean +/- s.e. mean) from 129.9 +/- 1.5 to 108.2 +/- 2.3 mm Hg (P less than 0.01) while it increased mean effective renal blood flow 512.5 +/- 86.6 to 646.0 +/- 116.1 ml min-1 1.73 m-2 (P less than 0.05) [11].
• Effective renal blood flow decreased significantly in response to angiotensin II leading to a significant increase in filtration fraction [12].

Gene context of Renal Blood Flow, Effective

• The highly purified CP4 fraction with ERBF activity in the binding assay with reconstituted chromatin caused an increase in the formation of the retarded ER-estrogen responsive element (ERE) band [13].
• Cl(CREAT), GFR and their difference remained unchanged, whereas ERBF tended to increase [14].
• A significant decrease (P < 0.01) in RVR and significant increases (P < 0.05) in ERPF, ERBF and in NaU were also found, without relevant changes in GFR, FF, PRA and ALD [15].
• It can be concluded that large amounts of myoglobin present in the renal tubules in envenomated animals can precipitate, particularly under acidic conditions, resulting in increased intratubular pressure and subsequently decreased renal hemodynamics including GFR and ERBF [16].
• All underwent standard measurements of glomerular filtration rate and effective renal blood flow using inulin and paraaminohippuric acid (PAH) clearances, respectively [17].

Analytical, diagnostic and therapeutic context of Renal Blood Flow, Effective

• Intravenous infusions of vasopressin for 1 h, resulting in plasma vasopressin concentrations of less than 1.25, 2.3, and 8.0 pg/ml, respectively, failed to change glomerular filtration rate (GFR) or effective renal blood flow (ERBF) significantly, nor were there significant changes during 5 h of infusion [9].

References