The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Renal Blood Flow, Effective

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Renal Blood Flow, Effective


High impact information on Renal Blood Flow, Effective

  • TAK-044 also reduced MAP (by up to 11+/-3%) and increased effective renal blood flow in the contralateral kidney (by up to 46+/-27%) [3].
  • In contrast, ERBF dose dependently suppressed IL-6-induced neuronal differentiation in PC-12 cells [4].
  • ERBF did not affect IL-2-dependent growth of CTLL-2 cells, IL-3-dependent growth of Baf3 cells, or tumor necrosis factor (TNF)alpha-induced growth suppression in TNFalpha-sensitive L929 cells [4].
  • ERBF also did not affect IL-4-stimulated expression of FcepsilonR II receptor (CD23) in U-937 cells, the IL-8-induced chemotaxis of human neutrophils, or nerve growth factor-stimulated neuronal differentiation in PC-12 cells [4].
  • These results clearly indicate that ERBF is a novel specific small molecule to show IL-6 receptor antagonist activity [4].

Biological context of Renal Blood Flow, Effective


Anatomical context of Renal Blood Flow, Effective

  • When synthetic vasopressin was given by osmotic minipumps for 10 days, with the rats gaining weight and thus changing the volume of their body fluids, GFR and ERBF increased significantly, by approximately 45 and 55%, respectively [9].

Associations of Renal Blood Flow, Effective with chemical compounds

  • In the course of a screening program aimed at IL-6 inhibitor from natural products, we isolated 20S,21-epoxy-resibufogenin-3-formate (ERBF) from bufadienolide and examined the effect of ERBF on activities of various cytokines [4].
  • In healthy volunteers the mean difference in GFR was 4.8 ml min-1 (95% CI -8.2 to 17.7 ml min-1) and the mean difference in ERBF was 49.8 ml min-1 (95% CI -47.5 to 147 ml min-1) after celiprolol [10].
  • Nadolol reduced mean arterial pressure from 133.2 +/- 2.0 to 113.5 +/- 3 mm Hg (P less than 0.001) but reduced mean effective renal blood flow from 558.8 +/- 32.2 to 446.0 +/- 26.9 ml min-1 1.73 m-2 (P less than 0.05) [11].
  • Atenolol lowered mean arterial pressure (mean +/- s.e. mean) from 129.9 +/- 1.5 to 108.2 +/- 2.3 mm Hg (P less than 0.01) while it increased mean effective renal blood flow 512.5 +/- 86.6 to 646.0 +/- 116.1 ml min-1 1.73 m-2 (P less than 0.05) [11].
  • Effective renal blood flow decreased significantly in response to angiotensin II leading to a significant increase in filtration fraction [12].

Gene context of Renal Blood Flow, Effective

  • The highly purified CP4 fraction with ERBF activity in the binding assay with reconstituted chromatin caused an increase in the formation of the retarded ER-estrogen responsive element (ERE) band [13].
  • Cl(CREAT), GFR and their difference remained unchanged, whereas ERBF tended to increase [14].
  • A significant decrease (P < 0.01) in RVR and significant increases (P < 0.05) in ERPF, ERBF and in NaU were also found, without relevant changes in GFR, FF, PRA and ALD [15].
  • It can be concluded that large amounts of myoglobin present in the renal tubules in envenomated animals can precipitate, particularly under acidic conditions, resulting in increased intratubular pressure and subsequently decreased renal hemodynamics including GFR and ERBF [16].
  • All underwent standard measurements of glomerular filtration rate and effective renal blood flow using inulin and paraaminohippuric acid (PAH) clearances, respectively [17].

Analytical, diagnostic and therapeutic context of Renal Blood Flow, Effective


  1. Effects of deliberate hypotension induced by labetalol on renal function. Toivonen, J., Kaukinen, S., Oikkonen, M., Hannelin, M. European journal of anaesthesiology. (1991) [Pubmed]
  2. Pharmacokinetic and pharmacodynamic properties and therapeutic use of bunazosin in hypertension. A review. Weidinger, G. Arzneimittel-Forschung. (1995) [Pubmed]
  3. Renal haemodynamic effects of endothelin-1 and the ETA/ETB antagonist TAK-044 in anaesthetized rabbits. Evans, R.G., Bergström, G., Cotterill, E., Anderson, W.P. J. Hypertens. (1998) [Pubmed]
  4. Biological activity of a novel nonpeptide antagonist to the interleukin-6 receptor 20S,21-epoxy-resibufogenin-3-formate. Hayashi, M., Rho, M.C., Fukami, A., Enomoto, A., Nonaka, S., Sekiguchi, Y., Yanagisawa, T., Yamashita, A., Nogawa, T., Kamano, Y., Komiyama, K. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  5. Nitrendipine and renal tubular function in human volunteers. Forsyth, D.R., Roberts, C.J. Journal of clinical pharmacology. (1992) [Pubmed]
  6. Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses. Held, J.P., Daniel, G.B. Am. J. Vet. Res. (1991) [Pubmed]
  7. Influence of indomethacin on renal function in conscious newborn lambs. Winther, J.B., Hoskins, E., Printz, M.P., Mendoza, S.A., Kirkpatrick, S.E., Friedman, W.F. Biol. Neonate (1980) [Pubmed]
  8. Complement activation in peritonitis. Association with hepatic and renal perfusion abnormalities. First place winner: Conrad Jobst award. Schirmer, W.J., Schirmer, J.M., Naff, G.B., Fry, D.E. The American surgeon. (1987) [Pubmed]
  9. Influence of vasopressin on renal hemodynamics in conscious Brattleboro rats. Gellai, M., Silverstein, J.H., Hwang, J.C., LaRochelle, F.T., Valtin, H. Am. J. Physiol. (1984) [Pubmed]
  10. The effect of celiprolol on glomerular filtration rate and renal blood flow in patients with chronic renal impairment and healthy volunteers. Robson, R.A., Bridgman, P.G., Wells, J.E., Bailey, R.R., Lynn, K.L. British journal of clinical pharmacology. (1992) [Pubmed]
  11. Antihypertensive and renal haemodynamic effects of atenolol and nadolol in elderly hypertensive patients. O'Callaghan, W.G., Laher, M.S., McGarry, K., O'Brien, E., O'Malley, K. British journal of clinical pharmacology. (1983) [Pubmed]
  12. Renal actions of the angiotensin AT2 receptor ligands CGP 42112 and PD 123319 after blockade of the renin-angiotensin system. Macari, D., Whitebread, S., Cumin, F., De Gasparo, M., Levens, N. Eur. J. Pharmacol. (1994) [Pubmed]
  13. Estrogen receptor interaction with specific histones. Binding to genomic DNA and an estrogen response element. Ruh, M.F., Cox, L.K., Ruh, T.S. Biochem. Pharmacol. (1996) [Pubmed]
  14. Renal effects of low-dose dopamine during vasopressor therapy for posttraumatic intracranial hypertension. Benmalek, F., Behforouz, N., Benoist, J.F., Lafay, M., Mimoz, O., Samii, K., Edouard, A.R. Intensive care medicine. (1999) [Pubmed]
  15. Effects of amlodipine on renal haemodynamics in mild to moderate hypertensive patients. A randomized controlled study versus placebo. Licata, G., Scaglione, R., Ganguzza, A., Parrinello, G., Costa, R., Merlino, G., Corrao, S., Amato, P. Eur. J. Clin. Pharmacol. (1993) [Pubmed]
  16. Renal function following sea snake venom (Lapemis hardwicki) administration in dogs treated with sodium bicarbonate solution. Sakwiwatkul, K., Chaiyabutr, N., Sitprija, V. Journal of natural toxins. (2002) [Pubmed]
  17. Renal function, sodium and water homeostasis in patients with idiopathic extrahepatic portal vein thrombosis compared with normal healthy controls. Rayner, B.L., Robson, S.C., Kirsch, R.E., Voigt, M. S. Afr. Med. J. (2001) [Pubmed]
WikiGenes - Universities