Chemical Compound Review:
Remikiren (2S)-2-benzyl-N-[(1S)-1- [[(2R,3S,4R)-1...
Synonyms:
AC1NUWCS, CHEMBL31601, SureCN156394, CCRIS 6519, CHEBI:142751, ...
- Efficacy and tolerability of the renin inhibitor Ro 42-5892 in patients with hypertension. Rongen, G.A., Lenders, J.W., Kleinbloesem, C.H., Weber, C., Welker, H., Fahrner, E., Pozenel, H., Woittiez, A.J., Haug, G., Buchmann, M.S. Clin. Pharmacol. Ther. (1993)
- A comparison of the effects of renin inhibition and angiotensin converting enzyme inhibition upon bradykinin potentiation. Véniant, M., Clozel, J.P., Fischli, W. J. Hypertens. (1992)
- Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function. van Paassen, P., de Zeeuw, D., Navis, G., de Jong, P.E. Nephrol. Dial. Transplant. (2000)
- Renin inhibitors as an example of presumptive irrelevant positive findings in the Salmonella/mammalian microsome assay (Ames test). Albertini, S., Gocke, E. Mutat. Res. (1993)
- Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects. Lachurié, M.L., Azizi, M., Guyene, T.T., Alhenc-Gelas, F., Ménard, J. Circulation (1995)
- Blood pressure control by the renin-angiotensin system in normotensive subjects. Assessment by angiotensin converting enzyme and renin inhibition. Kiowski, W., Linder, L., Kleinbloesem, C., van Brummelen, P., Bühler, F.R. Circulation (1992)
- Does the renin-angiotensin system determine the renal and systemic hemodynamic response to sodium in patients with essential hypertension? van Paassen, P., de Zeeuw, D., Navis, G., de Jong, P.E. Hypertension (1996)
- Is the antiproteinuric response to inhibition of the renin-angiotensin system less effective during the night? Buter, H., Hemmelder, M.H., van Paassen, P., Navis, G., de Zeeuw, D., de Jong, P.E. Nephrol. Dial. Transplant. (1997)
- Nonparallel effects of renin inhibitor treatment on plasma renin activity and angiotensins I and II in hypertensive subjects. An assay-related artifact. Derkx, F.H., van den Meiracker, A.H., Fischli, W., Admiraal, P.J., Man in't Veld, A.J., van Brummelen, P., Schalekamp, M.A. Am. J. Hypertens. (1991)
- Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects. Kleinbloesem, C.H., Weber, C., Fahrner, E., Dellenbach, M., Welker, H., Schröter, V., Belz, G.G. Clin. Pharmacol. Ther. (1993)
- Ro 42-5892 is a potent orally active renin inhibitor in primates. Fischli, W., Clozel, J.P., el Amrani, K., Wostl, W., Neidhart, W., Stadler, H., Branca, Q. Hypertension (1991)
- Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Nguyen, G., Delarue, F., Berrou, J., Rondeau, E., Sraer, J.D. Kidney Int. (1996)
- Assessment of the role of the renin-angiotensin system in cardiac contractility utilizing the renin inhibitor remikiren. van Kats, J.P., Sassen, L.M., Danser, A.H., Polak, M.P., Soei, L.K., Derkx, F.H., Schalekamp, M.A., Verdouw, P.D. Br. J. Pharmacol. (1996)
- Excretion and metabolism of remikiren, a potent orally active inhibitor of primate renin. Jauch, R., Schmid, P., Fischli, W., Meister, W., Maurer, R., Wendt, G. Xenobiotica (1996)
- Effects of renin-angiotensin system blockade in guinea pigs. Véniant, M., Clozel, J.P., Hess, P., Fischli, W. Hypertension (1992)
- Comparison of blood pressure and angiotensin responses to the renin inhibitor Ro 42-5892 and the angiotensin converting enzyme inhibitor enalapril in essential hypertension. van den Meiracker, A.H., Admiraal, P.J., Derkx, F.H., Kleinbloesem, C., Man in 't Veld, A.J., van Brummelen, P., Mulder, P., Schalekamp, M.A. J. Hypertens. (1993)
- Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Huang, Y., Wongamorntham, S., Kasting, J., McQuillan, D., Owens, R.T., Yu, L., Noble, N.A., Border, W. Kidney Int. (2006)
- Angiotensinogen concentrations and renin clearance : implications for blood pressure regulation. Bohlender, J., Ménard, J., Ganten, D., Luft, F.C. Hypertension (2000)
- Human renin-dependent hypertension in rats transgenic for human angiotensinogen. Bohlender, J., Ménard, J., Wagner, J., Luft, F.C., Ganten, D. Hypertension (1996)
- Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension. van Paassen, P., Navis, G.J., De Jong, P.E., De Zeeuw, D. Eur. J. Clin. Invest. (1999)
- Time dependency of the antihypertensive efficacy of the new renin inhibitor Ro 42-5892. Viskoper, R.J., Charlon, V., Laszt, A., Yosefy, C., Bock, J., Landau, M., Kobrin, I. Journal of human hypertension. (1994)
- Neurohormonal and blood pressure responses to low-dose infusion of an orally active renin inhibitor, Ro 42-5892, in salt-replete men. Doig, J.K., MacFadyen, R.J., Meredith, P.A., Fischli, W., Reid, J.L. J. Cardiovasc. Pharmacol. (1992)
- Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Richter, W.F., Whitby, B.R., Chou, R.C. Xenobiotica (1996)