Disease relevance of triflupromazine

• Methergoline and triflupromazine were more selective against tryptamine-induced hyperthermia, while cyproheptadine was more selective against 5-HT-induced hypothermia [1].
• Deep ether anaesthesia combined with large quantities of ganglion blocking agents (triflupromazine 3 mg/kg) constitutes the anaesthetic management of choice for deep surface-induced hypothermia [2].
• The antipsychotic phenothiazine triflupromazine, possessing a methyl-thio substituent at position 10 and a fluorine moiety at position 2, exhibited significant antibacterial activity against 279 strains of Gram-positive and Gram-negative bacteria [3].
• Triflupromazine, when injected intraperitoneally into Swiss albino mice at a concentration of 30 microg/mouse (20 g), manifested a significant protection to the mice (p<0.001) when they were challenged with 50 median lethal dose (MLD) of Salmonella typhimurium NCTC 74 [3].

High impact information on triflupromazine

• Trifluoperazine (10(-6) M), triflupromazine (10(-6) M) and penfluridol (10(-7) M) had an inhibitory effect on the stimulation of SRIF release induced by GRF and failed to alter resting release [4].
• The calmodulin antagonists used were N-(6-aminohexyl)-5-chloro-naphthalene-1-sulfonamide (W-7), triflupromazine and trifluoperazine [5].
• Two compounds, clozapine and triflupromazine, were selective for the M1 subtype [6].
• Limits of detection ranged from 4 nM for triflupromazine and trimeprazine to 300 nM for phenothiazine for the fluorescence spectroscopic detection of the sulfoxide and from 0.3 microM for phenothiazine and triflupromazine to 2 microM for trifluperazine for the UV-Vis spectroscopic detection of the radical cation [7].
• Out of the six derivatives tested (trifluoperazine, chlorpromazine, triflupromazine, thioridazine, acetopromazine and fluphenazine), trifluoperazine appears to be a more potent antitubercular drug than others with a minimum inhibitory concentration (MIC) of 5 micrograms/ml [8].

Biological context of triflupromazine

• Six chemicals, diethylhexyl phthalate (DEHP), ethanol, cyclohexylamine (CHA), sodium saccharin (NaS), cadmium chloride (CdCl2) and triflupromazine (TFP), were suggested to be unique germ-cell mutagens (Auletta and Ashby, 1988) by the GeneTox Workgroups of the U.S. Environmental Protection Agency (EPA) [9].
• The kinetics of TFPr were found to be biphasic: a slow onset was followed by a fast release reaction [10].

Anatomical context of triflupromazine

• To determine the morphologic correlate of cold-insoluble tubulin, segments of rat optic nerves were exposed to a series of in vitro experimental conditions that affect microtubules (MTs), including cold, podophyllotoxin (PT), triflupromazine (TFP), and taxol, and then examined by electron microscopy [11].
• In all the animals triflupromazine was administered intramuscularly in the gluteal region at the rate of 2 mg/kg [12].

Analytical, diagnostic and therapeutic context of triflupromazine

• Plasma samples were assayed by an HPLC method with triflupromazine as the internal standard [13].

References