Disease relevance of Alimemazine

• Delayed profound respiratory depression after premedication with trimeprazine [1].
• The addition of droperidol to the trimeprazine syrup produces greater uniformity in pre-operative sedation, a low incidence of postoperative vomiting, and a reduced requirement for postoperative analgesia [2].
• Effects of trimeprazine and trimipramine on nocturnal scratching in patients with atopic eczema [3].
• Neuroleptic malignant syndrome in a 4-year-old girl associated with alimemazine [4].
• The age, sex, body weight, duration of fasting, administration of trimeprazine, type of general surgical procedure, maintenance technique for general anaesthesia, duration of general anaesthesia, the administration of opiods or local anaesthetics and the incidence of POV were noted [5].

High impact information on Alimemazine

• Our data suggest that repetin and SPRR1A and 2A are downregulated in response to the downregulation of Klf4 in the transgenic animals, which would contribute to decreased protein crossbridging leading to fragile, defective cornified envelopes [6].
• We demonstrate that MHC class II Ags can be experimentally induced on thyroid cells by pharmacologic concentrations of alimemazine, a drug commonly used in psychiatry [7].
• Our results indicate that repetin is indeed a member of the fused gene family similar to the prototypical members profilaggrin and trichohyalin [8].
• The human repetin gene is a member of the "fused" gene family and localized in the epidermal differentiation complex on chromosome 1q21 [8].
• The repetin protein of 784 amino acids contains EF (a structure resembling the E helix-calcium-binding loop-F helix domain of parvalbumin) hands of the S100 type and internal tandem repeats typical for CE precursor proteins, a combination which is characteristic for "fused" proteins [8].

Chemical compound and disease context of Alimemazine

• Promethazine and trimeprazine sensitized anoxic E. coli B/r cells to 60Co gamma-rays, but both drugs showed a radioprotective effect under euoxic conditions [9].
• A 4-year-old girl comatose after poisoning by the histamine antagonist, alimemazine, developed chondronecrosis after a 2-day period of intubation [10].
• In a single-blind controlled study, forty children with congenital heart disease were premedicated with oral trimeprazine 3 mg/kg and either intramuscular morphine 0.1 mg/kg or oral ketamine 10 mg/kg [11].

Biological context of Alimemazine

• The repetin gene consists of three exons and two introns [12].
• After the oral administration of trimeprazine, the urinary metabolites were extracted with diethyl ether before or after hydrolysis with beta-glucuronidase [13].
• Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection [14].
• The stability, partition coefficient, plasma protein binding, red blood cell distribution, and whole blood concentrations of trimeprazine were investigated [14].
• The intestinal absorption of vitamin A was reduced (P<0.05) in the amiodarone group compared with the placebo and trimeprazine groups, which did not differ significantly from each other [15].

Anatomical context of Alimemazine

• For each of the four sedative agents (azatidine, chlorpheniramine, diphenhydramine and trimeprazine), reactions associated with the cardiovascular, gastrointestinal, central nervous systems, the skin, general and psychiatric reactions made up more than 70% of total reported reactions [16].
• For sedative purposes, increasing doses of alimemazine were administered to a 4-year-old multiple handicapped girl, with cerebral damage of the basal ganglia [4].
• No trimeprazine was detected in the cerebrospinal fluid [17].

Associations of Alimemazine with other chemical compounds

• 0. Reversal of the enantiomer migration order of promethazine, ethopropazine, and trimeprazine was observed by varying gamma-CD concentration in the range of 5-9 mM, 2.5-4.5 mM and 1.5-2.8 mM, respectively, using 100 mM citrate buffer at pH 3 [18].
• Premedication for children with oral trimeprazine and droperidol [2].
• Premedication with trimeprazine caused significantly more sedation than temazepam or placebo in patients on arrival in the anaesthetic room (P less than 0.02) [19].
• Oral premedication in children. A comparison of trimeprazine with a trimeprazine, droperidol and methadone mixture [20].
• One hundred and ninety-nine children received lorazepam 0.05 mg kg-1 or trimeprazine 3 mg kg-1 as oral premedication in a double-blind trial [21].

Gene context of Alimemazine

• Repetin (Rptn), a new member of the "fused gene" subgroup within the S100 gene family encoding a murine epidermal differentiation protein [12].
• Therefore, we investigated whether alimemazine applied at pharmacologic doses would modify the expression of thyroid antigens, and simultaneously, the expression of intercellular adhesion molecule-1 (ICAM-1), B7, and LFA-1 co-receptors in human TEC in culture [22].
• The "fused" gene family comprises profilaggrin, trichohyalin, repetin, hornerin, the profilaggrin-related protein and a protein encoded by c1orf10 [8].
• By fluorescence in situ hybridization the repetin gene was localized to chromosome band 3 F1-2 [12].

Analytical, diagnostic and therapeutic context of Alimemazine

• Following premedication with midazolam none of the patients was anxious, crying or distressed on leaving the ward, compared with 2/28 in the trimeprazine group and 5/28 in the placebo group (p = 0.0007) [23].
• Delayed, profound respiratory depression occurred in a 4-year-old boy, who had been premedicated with trimeprazine 4 h after tonsillectomy [24].
• The HPLC-EC procedures for chlorpromazine and trimeprazine were compared with GC-MS and radioimmunoassay procedures, respectively [25].
• On-line recovery of trimeprazine enantiomers following chiral separation by reversed-phase high-performance liquid chromatography using a beta-cyclodextrin-containing mobile phase [26].
• Trimeprazine or alimemazine is largely used as an antipruritic agent, but it is also used for insomnia, cough, and oral premedication in pediatric day surgery [27].

References