The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Spansule     N,N,2-trimethyl-3- phenothiazin-10-yl...

Synonyms: Alimezine, Repetin, Teralen, Oxomemazin, Alimemazina, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Alimemazine

 

High impact information on Alimemazine

  • Our data suggest that repetin and SPRR1A and 2A are downregulated in response to the downregulation of Klf4 in the transgenic animals, which would contribute to decreased protein crossbridging leading to fragile, defective cornified envelopes [6].
  • We demonstrate that MHC class II Ags can be experimentally induced on thyroid cells by pharmacologic concentrations of alimemazine, a drug commonly used in psychiatry [7].
  • Our results indicate that repetin is indeed a member of the fused gene family similar to the prototypical members profilaggrin and trichohyalin [8].
  • The human repetin gene is a member of the "fused" gene family and localized in the epidermal differentiation complex on chromosome 1q21 [8].
  • The repetin protein of 784 amino acids contains EF (a structure resembling the E helix-calcium-binding loop-F helix domain of parvalbumin) hands of the S100 type and internal tandem repeats typical for CE precursor proteins, a combination which is characteristic for "fused" proteins [8].
 

Chemical compound and disease context of Alimemazine

 

Biological context of Alimemazine

 

Anatomical context of Alimemazine

 

Associations of Alimemazine with other chemical compounds

 

Gene context of Alimemazine

 

Analytical, diagnostic and therapeutic context of Alimemazine

References

  1. Delayed profound respiratory depression after premedication with trimeprazine. Zsigmond, E.K., Hirota, K. Anaesthesia. (1993) [Pubmed]
  2. Premedication for children with oral trimeprazine and droperidol. Layfield, D.J., Walker, A.K. Anaesthesia. (1984) [Pubmed]
  3. Effects of trimeprazine and trimipramine on nocturnal scratching in patients with atopic eczema. Savin, J.A., Paterson, W.D., Adam, K., Oswald, I. Archives of dermatology. (1979) [Pubmed]
  4. Neuroleptic malignant syndrome in a 4-year-old girl associated with alimemazine. van Maldegem, B.T., Smit, L.M., Touw, D.J., Gemke, R.J. Eur. J. Pediatr. (2002) [Pubmed]
  5. Postoperative vomiting (POV) in the paediatric outpatient general surgical population. Goh, J.C., Ng, A.S., Sim, K.M. Singapore medical journal. (1999) [Pubmed]
  6. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Turksen, K., Troy, T.C. Development (2002) [Pubmed]
  7. Phenothiazine induces de novo MHC class II antigen expression on thyroid epithelial cells. A new mechanism for drug-induced autoimmunity. Takorabet, L., Ropars, A., Raby, C., Charreire, J. J. Immunol. (1995) [Pubmed]
  8. Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex. Huber, M., Siegenthaler, G., Mirancea, N., Marenholz, I., Nizetic, D., Breitkreutz, D., Mischke, D., Hohl, D. J. Invest. Dermatol. (2005) [Pubmed]
  9. Modification of radiation response of E. coli B/r cells by phenothiazines. Maniar, H.S., Singh, B.B. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1983) [Pubmed]
  10. Chondronecrosis of the cricoid cartilage after intubation. Two case reports. Wiel, E., Vilette, B., Solanet, C., Darras, J.A., Scherpereel, P. European journal of anaesthesiology. (1997) [Pubmed]
  11. Oral ketamine premedication for paediatric cardiac surgery--a comparison with intramuscular morphine (both after oral trimeprazine). Stewart, K.G., Rowbottom, S.J., Aitken, A.W., Rajendram, S., Sudhaman, D.A. Anaesthesia and intensive care. (1990) [Pubmed]
  12. Repetin (Rptn), a new member of the "fused gene" subgroup within the S100 gene family encoding a murine epidermal differentiation protein. Krieg, P., Schuppler, M., Koesters, R., Mincheva, A., Lichter, P., Marks, F. Genomics (1997) [Pubmed]
  13. Identification of new urinary metabolites of trimeprazine in rats by gas chromatography-mass spectrometry. Kim, T.J., Park, J.S., Shin, H.S. J. Chromatogr. (1992) [Pubmed]
  14. Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection. Hu, O.Y., Gfeller, E., Perrin, J.H., Curry, S.H. J. Pharm. Pharmacol. (1986) [Pubmed]
  15. A comparative study on the effects of oral amiodarone and trimeprazine, two in vitro retinyl ester hydrolase inhibitors, on the metabolic availability of vitamin A in rats. Schindler, R., Fielenbach, T., Rave, G. Br. J. Nutr. (2005) [Pubmed]
  16. Spontaneous reporting of suspected adverse reactions to antihistamines: a national and international perspective. Routledge, P.A., Lindquist, M., Edwards, I.R. Clin. Exp. Allergy (1999) [Pubmed]
  17. Pharmacokinetics of trimeprazine in children. Sponheim, S., Aune, H., Gulliksen, M., Mørland, J. Pharmacol. Toxicol. (1990) [Pubmed]
  18. Enantioseparation of phenothiazines in cyclodextrin-modified capillary zone electrophoresis: reversal of migration order. Lin, C.E., Liao, W.S., Chen, K.H. Electrophoresis (2003) [Pubmed]
  19. Temazepam and trimeprazine compared with placebo as premedication in children. An investigation extended into the first 2 weeks at home. Padfield, N.L., Twohig, M.M., Fraser, A.C. British journal of anaesthesia. (1986) [Pubmed]
  20. Oral premedication in children. A comparison of trimeprazine with a trimeprazine, droperidol and methadone mixture. Phillips, G.H., Mian, T., Becker, U., Stone, P.A., Jones, H.M. Anaesthesia. (1990) [Pubmed]
  21. Comparative study of lorazepam and trimeprazine for oral premedication in paediatric anaesthesia. Peters, C.G., Brunton, J.T. British journal of anaesthesia. (1982) [Pubmed]
  22. Phenothiazine-induced increase in thyroid autoantigens and costimulatory molecules on thyroid cells: a pathophysiological mechanism for drug-induced autoimmunity? Takorabet, L., Ropars, A., Stasiuk, L., Raby, C., Charreire, J. Clin. Exp. Immunol. (1998) [Pubmed]
  23. A comparison of midazolam with trimeprazine as an oral premedicant for children. Mitchell, V., Grange, C., Black, A., Train, J. Anaesthesia. (1997) [Pubmed]
  24. Delayed profound respiratory depression after premedication with trimeprazine. Chambers, F.A., O'Leary, E., Gormley, P.K., Flynn, N.M. Anaesthesia. (1992) [Pubmed]
  25. Recent advances in the analysis of phenothiazine drugs and their metabolites using high performance liquid chromatography. McKay, G., Geddes, J., Cowper, M.J., Gurnsey, T.S. Prog. Neuropsychopharmacol. Biol. Psychiatry (1983) [Pubmed]
  26. On-line recovery of trimeprazine enantiomers following chiral separation by reversed-phase high-performance liquid chromatography using a beta-cyclodextrin-containing mobile phase. Cooper, A.D., Jefferies, T.M. Journal of pharmaceutical and biomedical analysis. (1990) [Pubmed]
  27. Determination of trimeprazine-facilitated sedation in children by hair analysis. Kintz, P., Villain, M., Cirimele, V. Journal of analytical toxicology. (2006) [Pubmed]
 
WikiGenes - Universities