The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CCRIS 6152     cadmium(+2) cation dichloride

Synonyms: ACMC-20aljg, LS-7249, DSSTox_CID_226, AC1L2NKK, AC1Q1RLJ, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CADMIUM CHLORIDE

  • Our studies strongly support a role for HSP-reactive T cells in CdCl2-induced interstitial nephritis and suggest that the induction of HSPs in the kidney by a multitude of "non-immune" events may initiate or facilitate inflammatory damage by HSP-reactive lymphocytes [1].
  • Neurtrophil degranulation in cadmium-chloride-induced acute lung inflammation [2].
  • By 4 and 7 days after CdCl2, various forms of intraluminal fibrosis, including intrabronchiolar budding, mural incorporation, and obliterative changes, were observed [3].
  • Lung injury induced by intratracheal instillation of cadmium chloride (CdCl2) into the rat lung may serve as a model of human interstitial lung disease [3].
  • Investigation of acute toxicity of cadmium chloride (CdCl2 . H2O) metal salt and behavioral changes it causes on water frog (Rana ridibunda Pallas, 1771) [4].

High impact information on CADMIUM CHLORIDE

  • CdCl2 also induces HSP70 expression in cultured tubular epithelial cells from SJL/J mice [1].
  • Neither AA nor CdCl2 affected cell viability, Na+-glucose cotransport or total rate of protein synthesis [5].
  • METHODS: The effects of AA on PT functions including reabsorption of LMWP were investigated on the well-established opossum kidney (OK) cell line, a model for PT, and compared with those of the classical PT toxin cadmium chloride (CdCl2) [5].
  • A strong accumulation of the LeUBC1-transcript was observed by exposure to heavy metal stress which was performed by treatment with cadmium chloride (CdCl2) [6].
  • CONCLUSIONS: These findings suggest that CdCl2 induces impairment of testicular function and causes a marked reduction in testicular LDH-X activity; that LDH-X activity is a biological marker of testicular damage; and that, except at high doses of CdCl2, this damage can be prevented by oxypurinol or SOD [7].

Biological context of CADMIUM CHLORIDE


Anatomical context of CADMIUM CHLORIDE

  • CD4+, TCR-alpha/beta+ T cell lines specific for an immunodominant HSP peptide are cytotoxic to heat stressed or CdCl2-treated renal tubular cells [1].
  • The prostate epithelium of rats which received repeated cadmium chloride (CdCl2) injections showed a gradual disruption of structural differentiation [10].
  • Ethanol and CdCl2 showed clastogenic activity, but it was not restricted to germ cells [11].
  • Changes in the number and ex vivo function of peripheral blood neutrophils were investigated following intraperitoneal administration of cadmium-chloride in rats [12].
  • We have utilized this system for examining the effects of cadmium chloride (CdCl2) and other toxic substances known to affect the testis [13].

Associations of CADMIUM CHLORIDE with other chemical compounds


Gene context of CADMIUM CHLORIDE


Analytical, diagnostic and therapeutic context of CADMIUM CHLORIDE

  • Such HSP-reactive T cells mediate an inflammatory interstitial nephritis after adoptive transfer to CdCl2-treated mice at a time when immunoreactive HSP70 is detectable in the kidneys, but before the development of interstitial mononuclear cell infiltrates [1].
  • Two doses (400 micrograms or 50 micrograms of CdCl2, each in 400 microliters of neutral saline) were used and the morphologic changes occurring during the first 7 days after a single exposure were documented by light and electron microscopy [3].


  1. T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis. Weiss, R.A., Madaio, M.P., Tomaszewski, J.E., Kelly, C.J. J. Exp. Med. (1994) [Pubmed]
  2. Neurtrophil degranulation in cadmium-chloride-induced acute lung inflammation. Yamada, H., Damiano, V.V., Tsang, A.L., Meranze, D.R., Glasgow, J., Abrams, W.R., Weinbaum, G. Am. J. Pathol. (1982) [Pubmed]
  3. Intraluminal fibrosis induced unilaterally by lobar instillation of CdCl2 into the rat lung. Damiano, V.V., Cherian, P.V., Frankel, F.R., Steeger, J.R., Sohn, M., Oppenheim, D., Weinbaum, G. Am. J. Pathol. (1990) [Pubmed]
  4. Investigation of acute toxicity of cadmium chloride (CdCl2 . H2O) metal salt and behavioral changes it causes on water frog (Rana ridibunda Pallas, 1771). Selvi, M., Gül, A., Yilmaz, M. Chemosphere (2003) [Pubmed]
  5. Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells. Lebeau, C., Arlt, V.M., Schmeiser, H.H., Boom, A., Verroust, P.J., Devuyst, O., Beauwens, R. Kidney Int. (2001) [Pubmed]
  6. Isolation of a cDNA coding for an ubiquitin-conjugating enzyme UBC1 of tomato--the first stress-induced UBC of higher plants. Feussner, K., Feussner, I., Leopold, I., Wasternack, C. FEBS Lett. (1997) [Pubmed]
  7. Prevention of testicular damage by free-radical scavengers. Agarwal, A., Ikemoto, I., Loughlin, K.R. Urology (1997) [Pubmed]
  8. Increased heat shock protein 70 expression following toxicant-mediated cytotoxicity: a ubiquitous marker of toxicant exposure? Farzaneh, P., Allameh, A., Pratt, S., Moore, N., Travis, L., Gottschalg, E., Kind, C., Fry, J. Alternatives to laboratory animals : ATLA. (2005) [Pubmed]
  9. Effect of cadmium (CdCl2) on cell proliferation and production of EDRF (endothelium-derived relaxing factor) by cultured human umbilical arterial endothelial cells. Kishimoto, T., Oguri, T., Ohno, M., Matsubara, K., Yamamoto, K., Tada, M. Arch. Toxicol. (1994) [Pubmed]
  10. Electron microscopic results on the ventral prostate of the rat after CdCl2 administration. A contribution towards etiology of the cancer of the prostate. Hoffmann, L., Putzke, H.P., Bendel, L., Erdmann, T., Huckstorf, C. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
  11. The present lack of evidence for unique rodent germ-cell mutagens. Adler, I.D., Ashby, J. Mutat. Res. (1989) [Pubmed]
  12. Granulocyte and plasma cytokine activity in acute cadmium intoxication in rats. Kataranovski, M., Kataranovski, D., Savic, D., Jovcic, G., Bogdanovic, Z., Jovanovic, T. Physiological research / Academia Scientiarum Bohemoslovaca. (1998) [Pubmed]
  13. Sensitivity of Sertoli and Leydig cells to xenobiotics in in vitro models. Steinberger, A., Klinefelter, G. Reprod. Toxicol. (1993) [Pubmed]
  14. The alkaline comet test on plant cells: a new genotoxicity test for DNA strand breaks in Vicia faba root cells. Koppen, G., Verschaeve, L. Mutat. Res. (1996) [Pubmed]
  15. Release of calcitonin gene-related peptide from rat enteric nerves is Ca2+-dependent but is not induced by K+ depolarization. Belai, A., Burnstock, G. Regul. Pept. (1988) [Pubmed]
  16. Cellular response after mobilization of metals by diethyldithiocarbamate in rat hepatocyte cultures. Hellström-Lindahl, E., Oskarsson, A. Toxicology (1990) [Pubmed]
  17. Cytochrome P4501A responses in two tropical fish species, riverine catfish (Rita rita) and marine mudfish (Apocryptes bato). Al-Arabi, S.A., Goksøyr, A. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2002) [Pubmed]
  18. Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema. Snider, G.L., Lucey, E.C., Faris, B., Jung-Legg, Y., Stone, P.J., Franzblau, C. Am. Rev. Respir. Dis. (1988) [Pubmed]
WikiGenes - Universities