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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Fibroadenoma


Psychiatry related information on Fibroadenoma


High impact information on Fibroadenoma


Chemical compound and disease context of Fibroadenoma


Biological context of Fibroadenoma


Anatomical context of Fibroadenoma


Gene context of Fibroadenoma

  • The level of expression of Wnt2 and Wnt4 was 10- to 20-fold higher in fibroadenomas than it was in normal or malignant breast tissue, and in 10% of tumors Wnt7b expression was 30-fold higher than in normal or benign breast tissues [26].
  • Using newly developed quantitative activity assays, the levels of active MMP-2, total (active and activatable) MMP-2 and total MMP-9 were found to be significantly higher in breast carcinomas than in fibroadenomas [27].
  • EGFR was regularly expressed preferentially in the myoepithelial cells of mammary ducts in the fibroadenomas and in nontumorous glands [28].
  • Most fibroadenomas showed weak positivity for ET-1 (83%) and ET-3 (67%) [29].
  • The aim of this study was to evaluate the distribution of aFGF and FGFR4 in specific cell types of fibroadenomas to understand their possible role in the growth of these breast lesions [30].

Analytical, diagnostic and therapeutic context of Fibroadenoma


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  2. Benign breast disease and consumption of beverages containing methylxanthines. La Vecchia, C., Franceschi, S., Parazzini, F., Regallo, M., Decarli, A., Gallus, G., Di Pietro, S., Tognoni, G. J. Natl. Cancer Inst. (1985) [Pubmed]
  3. Mammary tumorigenesis in chemical carcinogen-treated mice. IV. Induction of mammary ductal hyperplasias. Medina, D., Warner, M.R. J. Natl. Cancer Inst. (1976) [Pubmed]
  4. Assessment of interaction among three carcinogens on rat mammary carcinogenesis in a factorially designed experiment. Shellabarger, C.J., Machado, S.G., Holtzman, S., Stone, J.P. J. Natl. Cancer Inst. (1987) [Pubmed]
  5. Promotion by prolactin of the growth of human breast neoplasms cultured in vitro in the soft agar clonogenic assay. Manni, A., Wright, C., Davis, G., Glenn, J., Joehl, R., Feil, P. Cancer Res. (1986) [Pubmed]
  6. Risk factors for fibroadenoma: a case-control study in Australia. Yu, H., Rohan, T.E., Cook, M.G., Howe, G.R., Miller, A.B. Am. J. Epidemiol. (1992) [Pubmed]
  7. Telomerase activity in human breast tumors. Hiyama, E., Gollahon, L., Kataoka, T., Kuroi, K., Yokoyama, T., Gazdar, A.F., Hiyama, K., Piatyszek, M.A., Shay, J.W. J. Natl. Cancer Inst. (1996) [Pubmed]
  8. Characterization of a monoclonal antibody reactive with a subset of human breast tumors. Yuan, D., Hendler, F.J., Vitetta, E.S. J. Natl. Cancer Inst. (1982) [Pubmed]
  9. Mammary carcinogenic effect of low-dose fission radiation in Wistar/Furth rats and its dependency on prolactin. Yokoro, K., Sumi, C., Ito, A., Hamada, K., Kanda, K., Kobayashi, T. J. Natl. Cancer Inst. (1980) [Pubmed]
  10. Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression. Wolf, C., Rouyer, N., Lutz, Y., Adida, C., Loriot, M., Bellocq, J.P., Chambon, P., Basset, P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  11. Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Arteaga, C.L., Johnson, M.D., Todderud, G., Coffey, R.J., Carpenter, G., Page, D.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  12. Mammary tumors induced in rats by adriamycin and daunomycin. Solcia, E., Ballerini, L., Bellini, O., Sala, L., Bertazzoli, C. Cancer Res. (1978) [Pubmed]
  13. Variation in glycosaminoglycan components of breast tumors. Takeuchi, J., Sobue, M., Sato, E., Shamoto, M., Miura, K. Cancer Res. (1976) [Pubmed]
  14. Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas. Balakrishnan, A., Cramer, S., Bandyopadhyay, G.K., Imagawa, W., Yang, J., Elias, J., Beattie, C.W., Das Gupta, T.K., Nandi, S. Cancer Res. (1989) [Pubmed]
  15. Isozyme patterns of normal, benign, and malignant human breast tissues. Balinsky, D., Platz, C.E., Lewis, J.W. Cancer Res. (1983) [Pubmed]
  16. Absence of genetic abnormalities in fibroadenomas of the breast determined at p53 gene mutations and microsatellite alterations. Franco, N., Picard, S.F., Mege, F., Arnould, L., Lizard-Nacol, S. Cancer Res. (2001) [Pubmed]
  17. Estradiol 17 beta-hydroxysteroid dehydrogenase activity in human breast fibroadenomas. Fournier, S., Kuttenn, F., de Cicco, F., Baudot, N., Malet, C., Mauvais-Jarvis, P. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  18. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. Cassoni, P., Papotti, M., Ghè, C., Catapano, F., Sapino, A., Graziani, A., Deghenghi, R., Reissmann, T., Ghigo, E., Muccioli, G. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  19. 31P magnetic resonance phospholipid profiles of neoplastic human breast tissues. Merchant, T.E., Meneses, P., Gierke, L.W., Den Otter, W., Glonek, T. Br. J. Cancer (1991) [Pubmed]
  20. Mammary fibroadenoma and some phyllodes tumour stroma are composed of CD34+ fibroblasts and factor XIIIa+ dendrophages. Silverman, J.S., Tamsen, A. Histopathology (1996) [Pubmed]
  21. Carcinogenicity studies of astemizole in mice and rats. Benze, J., Gypen, L., Vandenberghe, J., Lampo, A., De Coster, R., Bowden, C., Van Cauteren, H. Cancer Res. (1995) [Pubmed]
  22. Multiple forms of plasminogen activator in human breast tumors. O'Grady, P., Lijnen, H.R., Duffy, M.J. Cancer Res. (1985) [Pubmed]
  23. Expression of the common acute lymphoblastic leukemia antigen (CD10) in mesenchymal tumors. Mechtersheimer, G., Möller, P. Am. J. Pathol. (1989) [Pubmed]
  24. Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis. Varley, J.M., Swallow, J.E., Brammar, W.J., Whittaker, J.L., Walker, R.A. Oncogene (1987) [Pubmed]
  25. Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast carcinoma. Yashima, K., Milchgrub, S., Gollahon, L.S., Maitra, A., Saboorian, M.H., Shay, J.W., Gazdar, A.F. Clin. Cancer Res. (1998) [Pubmed]
  26. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Huguet, E.L., McMahon, J.A., McMahon, A.P., Bicknell, R., Harris, A.L. Cancer Res. (1994) [Pubmed]
  27. Increased gelatinase-A and gelatinase-B activities in malignant vs. benign breast tumors. Hanemaaijer, R., Verheijen, J.H., Maguire, T.M., Visser, H., Toet, K., McDermott, E., O'Higgins, N., Duffy, M.J. Int. J. Cancer (2000) [Pubmed]
  28. Immunohistochemical study of TGF-alpha, TGF-beta1, EGFR, and IGF-1 expression in human breast carcinoma. Pilichowska, M., Kimura, N., Fujiwara, H., Nagura, H. Mod. Pathol. (1997) [Pubmed]
  29. Augmented expression of endothelin-1, endothelin-3 and the endothelin-B receptor in breast carcinoma. Alanen, K., Deng, D.X., Chakrabarti, S. Histopathology (2000) [Pubmed]
  30. Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. La Rosa, S., Sessa, F., Colombo, L., Tibiletti, M.G., Furlan, D., Capella, C. J. Clin. Pathol. (2001) [Pubmed]
  31. NY-ESO-1 expression and immunogenicity in malignant and benign breast tumors. Sugita, Y., Wada, H., Fujita, S., Nakata, T., Sato, S., Noguchi, Y., Jungbluth, A.A., Yamaguchi, M., Chen, Y.T., Stockert, E., Gnjatic, S., Williamson, B., Scanlan, M.J., Ono, T., Sakita, I., Yasui, M., Miyoshi, Y., Tamaki, Y., Matsuura, N., Noguchi, S., Old, L.J., Nakayama, E., Monden, M. Cancer Res. (2004) [Pubmed]
  32. Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast. Sawyer, E.J., Hanby, A.M., Poulsom, R., Jeffery, R., Gillett, C.E., Ellis, I.O., Ellis, P., Tomlinson, I.P. J. Pathol. (2003) [Pubmed]
  33. Folate conjugase activity in the plasma and tumors of breast-cancer patients. Baggott, J.E., Heimburger, D.C., Krumdieck, C.L., Butterworth, C.E. Am. J. Clin. Nutr. (1987) [Pubmed]
  34. Effect of testosterone and estradiol-17beta on synthesis of DNA, RNA and protein in human breast in organ culture. Finkelstein, M., Geier, A., Horn, H., Levij, I.S., Ever-Hadani, P. Int. J. Cancer (1975) [Pubmed]
  35. p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Barbareschi, M., Pecciarini, L., Cangi, M.G., Macrì, E., Rizzo, A., Viale, G., Doglioni, C. Am. J. Surg. Pathol. (2001) [Pubmed]
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