The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Suldox     4-amino-N-(5,6- dimethoxypyrimidin-4...

Synonyms: Fansidar (TN), SureCN125901, NSC-618943, LS-31248, NSC618943, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pyrimethamine-sulfadoxine


High impact information on Pyrimethamine-sulfadoxine


Chemical compound and disease context of Pyrimethamine-sulfadoxine


Biological context of Pyrimethamine-sulfadoxine


Associations of Pyrimethamine-sulfadoxine with other chemical compounds


Gene context of Pyrimethamine-sulfadoxine


Analytical, diagnostic and therapeutic context of Pyrimethamine-sulfadoxine


  1. Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. Gordeuk, V., Thuma, P., Brittenham, G., McLaren, C., Parry, D., Backenstose, A., Biemba, G., Msiska, R., Holmes, L., McKinley, E. N. Engl. J. Med. (1992) [Pubmed]
  2. Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial. Sulo, J., Chimpeni, P., Hatcher, J., Kublin, J.G., Plowe, C.V., Molyneux, M.E., Marsh, K., Taylor, T.E., Watkins, W.M., Winstanley, P.A. Lancet (2002) [Pubmed]
  3. Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine. Iyer, J.K., Milhous, W.K., Cortese, J.F., Kublin, J.G., Plowe, C.V. Lancet (2001) [Pubmed]
  4. Fatal hepatic necrosis due to pyrimethamine-sulfadoxine (Fansidar). Zitelli, B.J., Alexander, J., Taylor, S., Miller, K.D., Howrie, D.L., Kuritsky, J.N., Perez, T.H., Van Thiel, D.H. Ann. Intern. Med. (1987) [Pubmed]
  5. Use of pyrimethamine-sulfadoxine (Fansidar) in prophylaxis against chloroquine-resistant Plasmodium falciparum and Pneumocystis carinii. Pearson, R.D., Hewlett, E.L. Ann. Intern. Med. (1987) [Pubmed]
  6. Antifolate antimalarial resistance in southeast Africa: a population-based analysis. Roper, C., Pearce, R., Bredenkamp, B., Gumede, J., Drakeley, C., Mosha, F., Chandramohan, D., Sharp, B. Lancet (2003) [Pubmed]
  7. RII and RIII type resistance of Plasmodium falciparum to combination of mefloquine and sulfadoxine/pyrimethamine in Indonesia. Hoffman, S.L., Rustama, D., Dimpudus, A.J., Punjabi, N.H., Campbell, J.R., Oetomo, H.S., Marwoto, H.A., Harun, S., Sukri, N., Heizmann, P. Lancet (1985) [Pubmed]
  8. Susceptibility of Plasmodium falciparum to pyrimethamine and sulfadoxine/pyrimethamine in Kisumu, Kenya. Nguyen-Dinh, P., Spencer, H.C., Chemangey-Masaba, S., Churchill, F.C. Lancet (1982) [Pubmed]
  9. History, dynamics, and public health importance of malaria parasite resistance. Talisuna, A.O., Bloland, P., D'Alessandro, U. Clin. Microbiol. Rev. (2004) [Pubmed]
  10. Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications. Barnes, K.I., Little, F., Smith, P.J., Evans, A., Watkins, W.M., White, N.J. Clin. Pharmacol. Ther. (2006) [Pubmed]
  11. Randomised comparative study of mefloquine, qinghaosu, and pyrimethamine-sulfadoxine in patients with falciparum malaria. Li, G.Q., Arnold, K., Guo, X.B., Jian, H.X., Fu, L.C. Lancet (1984) [Pubmed]
  12. Resistance of Plasmodium falciparum malaria to sulfadoxine-pyrimethamine ('Fansidar') in a refugee camp in Thailand. Hurwitz, E.S., Johnson, D., Campbell, C.C. Lancet (1981) [Pubmed]
  13. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. Kublin, J.G., Cortese, J.F., Njunju, E.M., Mukadam, R.A., Wirima, J.J., Kazembe, P.N., Djimdé, A.A., Kouriba, B., Taylor, T.E., Plowe, C.V. J. Infect. Dis. (2003) [Pubmed]
  14. The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malaria. Schellenberg, D., Kahigwa, E., Drakeley, C., Malende, A., Wigayi, J., Msokame, C., Aponte, J.J., Tanner, M., Mshinda, H., Menendez, C., Alonso, P.L. Am. J. Trop. Med. Hyg. (2002) [Pubmed]
  15. Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria. Dzinjalamala, F.K., Macheso, A., Kublin, J.G., Taylor, T.E., Barnes, K.I., Molyneux, M.E., Plowe, C.V., Smith, P.J. Am. J. Trop. Med. Hyg. (2005) [Pubmed]
  16. Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Mutabingwa, T., Nzila, A., Mberu, E., Nduati, E., Winstanley, P., Hills, E., Watkins, W. Lancet (2001) [Pubmed]
  17. Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites. Basco, L.K., Tahar, R., Ringwald, P. Antimicrob. Agents Chemother. (1998) [Pubmed]
  18. Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America. Cortese, J.F., Caraballo, A., Contreras, C.E., Plowe, C.V. J. Infect. Dis. (2002) [Pubmed]
  19. Increased efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria among children with sickle cell trait in Western Kenya. Terlouw, D.J., Aidoo, M.A., Udhayakumar, V., Kolczak, M.S., Oloo, A.J., Kager, P.A., Lal, A.A., Nahlen, B.L., Kuile, F.O. J. Infect. Dis. (2002) [Pubmed]
  20. Rapid real-time PCR genotyping of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum. Alker, A.P., Mwapasa, V., Meshnick, S.R. Antimicrob. Agents Chemother. (2004) [Pubmed]
  21. Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria. Dorsey, G., Vlahos, J., Kamya, M.R., Staedke, S.G., Rosenthal, P.J. J. Infect. Dis. (2003) [Pubmed]
  22. Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Alker, A.P., Mwapasa, V., Purfield, A., Rogerson, S.J., Molyneux, M.E., Kamwendo, D.D., Tadesse, E., Chaluluka, E., Meshnick, S.R. Antimicrob. Agents Chemother. (2005) [Pubmed]
  23. DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy. Aubouy, A., Jafari, S., Huart, V., Migot-Nabias, F., Mayombo, J., Durand, R., Bakary, M., Le Bras, J., Deloron, P. J. Antimicrob. Chemother. (2003) [Pubmed]
  24. High-performance liquid chromatographic assay of pyrimethamine, sulfadoxine and its N4-acetyl metabolite in serum and urine after ingestion of Suldox. Midskov, C. J. Chromatogr. (1984) [Pubmed]
  25. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. Plowe, C.V., Cortese, J.F., Djimde, A., Nwanyanwu, O.C., Watkins, W.M., Winstanley, P.A., Estrada-Franco, J.G., Mollinedo, R.E., Avila, J.C., Cespedes, J.L., Carter, D., Doumbo, O.K. J. Infect. Dis. (1997) [Pubmed]
  26. Randomized Trial of 2-Dose versus Monthly Sulfadoxine-Pyrimethamine Intermittent Preventive Treatment for Malaria in HIV-Positive and HIV-Negative Pregnant Women in Malawi. Filler, S.J., Kazembe, P., Thigpen, M., Macheso, A., Parise, M.E., Newman, R.D., Steketee, R.W., Hamel, M. J. Infect. Dis. (2006) [Pubmed]
  27. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. Curtis, J., Duraisingh, M.T., Warhurst, D.C. J. Infect. Dis. (1998) [Pubmed]
  28. A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV. van Oosterhout, J.J., Laufer, M.K., Graham, S.M., Thumba, F., Perez, M.A., Chimbiya, N., Wilson, L., Chagomerana, M., Molyneux, M.E., Zijlstra, E.E., Taylor, T.E., Plowe, C.V. J. Acquir. Immune Defic. Syndr. (2005) [Pubmed]
  29. Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria. Amukoye, E., Winstanley, P.A., Watkins, W.M., Snow, R.W., Hatcher, J., Mosobo, M., Ngumbao, E., Lowe, B., Ton, M., Minyiri, G., Marsh, K. Antimicrob. Agents Chemother. (1997) [Pubmed]
WikiGenes - Universities