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Gene Review

BPGM  -  2,3-bisphosphoglycerate mutase

Homo sapiens

Synonyms: 2,3-bisphosphoglycerate mutase, erythrocyte, 2,3-bisphosphoglycerate synthase, 2,3-diphosphoglycerate mutase, BPG-dependent PGAM, Bisphosphoglycerate mutase, ...
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Disease relevance of BPGM


High impact information on BPGM


Biological context of BPGM

  • In situ hybridization experiments localized the human BPGM gene to chromosome 7 and, more precisely, to region 7q34----7q22 [6].
  • The seven amino acid residues, which have been shown to be essential for the three catalytic functions of the human BPGM, interact with the amino acids in the protein core, near the active site [7].
  • Subunit interfaces have also been constructed for BPGM by analogy with MPGM and suggest that, in addition to the known dimerization of BPGM, tetramerization may occur under certain conditions [7].
  • The revised amino acid sequence of the human BPGM is presented [8].
  • Therefore, the total BPGM deficiency results from a genetic compound with one allele coding for an inactive enzyme (mutation BPGM Créteil I) and the other bearing a frameshift mutation (mutation BPGM Créteil II) [1].

Anatomical context of BPGM


Associations of BPGM with chemical compounds


Other interactions of BPGM


Analytical, diagnostic and therapeutic context of BPGM


  1. Compound heterozygosity in a complete erythrocyte bisphosphoglycerate mutase deficiency. Lemarchandel, V., Joulin, V., Valentin, C., Rosa, R., Galactéros, F., Rosa, J., Cohen-Solal, M. Blood (1992) [Pubmed]
  2. An enzyme-linked immunosorbent assay and reference ranges for bisphosphoglycerate mutase in human erythrocytes. Takubo, T., Tsuda, I., Tatsumi, N., Kasuya, K., Taniguchi, Y., Fujita, T., Uchida, K., Matsuo, Y., Hayashi, T. J. Clin. Lab. Anal. (1998) [Pubmed]
  3. Erythrocytosis due to bisphosphoglycerate mutase deficiency with concurrent glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Hoyer, J.D., Allen, S.L., Beutler, E., Kubik, K., West, C., Fairbanks, V.F. Am. J. Hematol. (2004) [Pubmed]
  4. Molecular cloning and sequencing of the human erythrocyte 2,3-bisphosphoglycerate mutase cDNA: revised amino acid sequence. Joulin, V., Peduzzi, J., Roméo, P.H., Rosa, R., Valentin, C., Dubart, A., Lapeyre, B., Blouquit, Y., Garel, M.C., Goossens, M. EMBO J. (1986) [Pubmed]
  5. A recombinant bisphosphoglycerate mutase variant with acid phosphatase homology degrades 2,3-diphosphoglycerate. Garel, M.C., Arous, N., Calvin, M.C., Craescu, C.T., Rosa, J., Rosa, R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Chromosomal assignment of the human 2,3-bisphosphoglycerate mutase gene (BPGM) to region 7q34----7q22. Barichard, F., Joulin, V., Henry, I., Garel, M.C., Valentin, C., Rosa, R., Cohen-Solal, M., Junien, C. Hum. Genet. (1987) [Pubmed]
  7. Structural modeling of the human erythrocyte bisphosphoglycerate mutase. Craescu, C.T., Schaad, O., Garel, M.C., Rosa, R., Edelstein, S. Biochimie (1992) [Pubmed]
  8. Molecular cloning of the human 2,3-bisphosphoglycerate mutase cDNA and revised amino acid sequence. Cohen-Solal, M., Joulin, V., Romeo, P.H., Rosa, R., Valentin, C., Garel, M.C., Rosa, J. Biomed. Biochim. Acta (1987) [Pubmed]
  9. Cell-free translation of messenger RNA for human bisphosphoglyceromutase. Dubart, A., Romeo, P.H., Tsapis, A., Goossens, M., Rosa, R., Rosa, J. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  10. Isolation and characterization of the human 2,3-bisphosphoglycerate mutase gene. Joulin, V., Garel, M.C., Le Boulch, P., Valentin, C., Rosa, R., Rosa, J., Cohen-Solal, M. J. Biol. Chem. (1988) [Pubmed]
  11. Synthesis of 2,3-bisphosphoglycerate synthase in erythroid cells. Narita, H., Yanagawa, S., Sasaki, R., Chiba, H. J. Biol. Chem. (1981) [Pubmed]
  12. Critical role of human bisphosphoglycerate mutase Cys22 in the phosphatase activator-binding site. Ravel, P., Craescu, C.T., Arous, N., Rosa, J., Garel, M.C. J. Biol. Chem. (1997) [Pubmed]
  13. Metabolism of 3-phosphoglyceroyl phosphate in phosphoenolpyruvate-enriched human erythrocytes. Inoue, H., Moriyasu, M., Hamasaki, N. J. Biol. Chem. (1987) [Pubmed]
  14. Human bisphosphoglycerate mutase. Expression in Escherichia coli and use of site-directed mutagenesis in the evaluation of the role of the carboxyl-terminal region in the enzymatic mechanism. Garel, M.C., Joulin, V., Le Boulch, P., Calvin, M.C., Préhu, M.O., Arous, N., Longin, R., Rosa, R., Rosa, J., Cohen-Solal, M. J. Biol. Chem. (1989) [Pubmed]
  15. Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro. Fujita, T., Suzuki, K., Tada, T., Yoshihara, Y., Hamaoka, R., Uchida, K., Matuo, Y., Sasaki, T., Hanafusa, T., Taniguchi, N. J. Biochem. (1998) [Pubmed]
  16. Changes in glycolytic enzyme activities in aging erythrocytes fractionated by counter-current distribution in aqueous polymer two-phase systems. Jimeno, P., Garcia-Perez, A.I., Luque, J., Pinilla, M. Biochem. J. (1991) [Pubmed]
  17. The phosphoglycerate mutases. Fothergill-Gilmore, L.A., Watson, H.C. Adv. Enzymol. Relat. Areas Mol. Biol. (1989) [Pubmed]
  18. The identification of multiple molecular forms of human red cell phosphoglycerate mutase and 2,3-bisphosphoglycerate synthase by isoelectric focusing. Hass, L.F., Miller, K.B. J. Biol. Chem. (1978) [Pubmed]
  19. Crystallization and preliminary X-ray diffraction studies of the human erythrocyte bisphosphoglycerate mutase. Cherfils, J., Rosa, R., Garel, M.C., Calvin, M.C., Rosa, J., Janin, J. J. Mol. Biol. (1991) [Pubmed]
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