Disease relevance of Cefcanel

• In vitro activities of cefcanel and some other cephalosporins against Pasteurella multocida [1].
• The present study investigated the pharmacokinetics of cefcanel following a single oral dose of cefcanel daloxate hydrochloride 300 mg to healthy volunteers and to patients with various degrees of stable renal insufficiency [2].
• Against anaerobic cocci its MIC90 value was 16 mg/l, and against Bacteroides fragilis, 32 mg/l. Cefcanel has an antibacterial activity that warrants investigation in clinical trials [3].
• In general, cefcanel was more active than the other cephalosporins against the species Escherichia coli, Klebsiella aerogenes and Proteus mirabilis [4].
• The minimum inhibitory concentration of cefcanel, a new oral cephalosporin, has been determined for 182 clinical isolates, of which 84 were from the family Enterobacteriaceae, 45 were from the genus Streptococcus, 18 were nonfermentative rods, 25 were Haemophilus influenzae and 10 were Branhamella catarrhalis [4].

High impact information on Cefcanel

• Twenty individuals from 21 to 74 years of age received a single oral dose of cefcanel daloxate hydrochloride together with an i.v. bolus injection of iohexol for a simultaneous assessment of glomerular filtration rate (GFR) [2].
• It is probable that biotransformed materials, distinct from cefcanel, were formed in the gastrointestinal tract and slowly absorbed rather than being systemic products of metabolic degradation of cefcanel.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
• Determination of cefcanel in plasma and urine by high-performance liquid chromatography using coupled columns, after administration of the new cephalosporin prodrug cefcanel daloxate hydrochloride [6].
• The clinical and bacteriologic efficacy of 3 days of cefcanel daloxate therapy, compared with 3 days of amoxicillin for the treatment of acute uncomplicated urinary tract infection was compared in a prospective randomized double-blind multicentre study [7].
• Cefcanel was hydrolyzed by TEM-1, TEM-3 and Moraxella Bro-1 beta-lactamases [8].

Chemical compound and disease context of Cefcanel

• Comparative antibacterial activity of the new cephalosporin cefcanel against anaerobic bacteria [3].

Biological context of Cefcanel

• Although cefcanel inhibited gram-positive species as well as or at lower concentrations than other cephalosporins, it lacked activity against gram-negative species that produced common plasmid beta-lactamase although it inhibited Haemophilus influenzae carrying TEM-1 [8].
• The protein binding of cefcanel in TCF was approximately 98% [9].

Associations of Cefcanel with other chemical compounds

• The plasma and tissue peak levels of cefcanel following administration of the daloxate were lower than those for cefaclor but cefcanel displayed a longer half-life [10].

Gene context of Cefcanel

• In contrast, the beta-lactamase production of S. epidermidis did influence the activity of cefcanel [11].

Analytical, diagnostic and therapeutic context of Cefcanel

• The rabbits received different doses of cefcanel i.v. and unbound concentrations in the tissue cage fluid (TCF) were measured [9].

References