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Chemical Compound Review

Ro 07-0582     2-[4-(1,7- diazabicyclo[4.3.0]nona- 2,4,6,8...

Synonyms: Antopen, Miroprofen, Miroprofene, Miroprofeno, Miroprofenum, ...
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Disease relevance of Ro 07-0582


High impact information on Ro 07-0582


Biological context of Ro 07-0582

  • Y-9213 (0.1--10 micrometer) also inhibited significantly the phagocytic secretion of lysosomal enzymes from PMN leukocytes without affecting phagocytosis of the particles [9].
  • These findings indicate that miroprofen may be more effective in suppressing pain responses and acute inflammation accompanied with increased vascular permeability [10].

Anatomical context of Ro 07-0582


Associations of Ro 07-0582 with other chemical compounds


Gene context of Ro 07-0582

  • The response of a transplantable tumor to fractionated irradiation. III. Fast neutrons plus the radiosensitizer Ro-07-0582 [17].
  • A comparison of radiation-sensitizing ability and cell uptake for NDPP and Ro-07-0582 [18].

Analytical, diagnostic and therapeutic context of Ro 07-0582


  1. Modification of radiation responses of murine tumors by misonidazole (Ro 07-0582), host immune capability, and Corynebacterium parvum. Stone, H.B., Milas, L. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Clinical phase I study of the hypoxic cell radiosensitizer RO-07-0582, a 2-nitroimidazole derivative. Urtasun, R.C., Band, P., Chapman, J.D., Rabin, H.R., Wilson, A.F., Fryer, C.G. Radiology. (1977) [Pubmed]
  3. Interaction of hyperthermia and the hypoxic cell sensitizer Ro-07-0582 on the EMT6 mouse tumour. Bleehen, N.M., Honess, D.J., Morgan, J.E. Br. J. Cancer (1977) [Pubmed]
  4. Further investigations of the effects of the hypoxic-cell radiosensitizer, Ro-07-0582, on local control of a mouse tumour. Sheldon, P.W., Hill, S.A. Br. J. Cancer (1977) [Pubmed]
  5. Combined radiosensitization and radioprotection for oral cavity tumors: study with an oral cavity tumor model. Grigsby, P., Maruyama, Y. Int. J. Radiat. Oncol. Biol. Phys. (1982) [Pubmed]
  6. The penetration of misonidazole into a mature structural cartilage. Langler, A.J., Bugden, R.D., Gibson, P. Br. J. Cancer (1982) [Pubmed]
  7. Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine. Hall, E.J., Astor, M., Geard, C., Biaglow, J. Br. J. Cancer (1977) [Pubmed]
  8. Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro. Stratford, I.J., Adams, G.E. Br. J. Cancer (1977) [Pubmed]
  9. Effects of 2-(4-(2-imidazo[1,2-a]pyridyl)phenyl) propionic acid (Y-9213) and anti-inflammatory drugs on erythrocytes, polymorphonuclear leukocytes and lysosomes in vitro. Goto, K., Hisadome, M., Maruyama, Y., Imamura, H. Jpn. J. Pharmacol. (1978) [Pubmed]
  10. Anti-inflammatory activity of an imidazopyridine derivative (miroprofen). Maruyama, Y., Anami, K., Terasawa, M., Goto, K., Imayoshi, T., Kadobe, Y., Mizushima, Y. Arzneimittel-Forschung. (1981) [Pubmed]
  11. Radiosensitization of mouse spermatogenic stem cells by Ro-07-0582. Suzuki, N., Withers, H.R., Hunter, N. Radiat. Res. (1977) [Pubmed]
  12. Chemoradioprotection of the rat parotid gland by combined use of WR-2721 and Ro-07-0582. Sodicoff, M., Conger, A.D., Pratt, N.E., Sinesi, M., Trepper, P. Radiat. Res. (1979) [Pubmed]
  13. Effects of 2-[4-(2-imidazo[1,2-a]pyridyl)phenyl] propionic acid (Y-9213) on in vivo release of lysosomal enzymes from rat polymorphonuclear leukocytes during phagocytosis of particles. Goto, K., Hisadome, M., Imamura, H. Jpn. J. Pharmacol. (1979) [Pubmed]
  14. The penetration of misonidazole into spontaneous canine tumours. White, R.A., Workman, P., Owen, L.N., Bleehen, N.M. Br. J. Cancer (1979) [Pubmed]
  15. The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro. McNally, N.J. Br. J. Cancer (1975) [Pubmed]
  16. Free-radical formation in gamma-irradiated oriented DNA containing electron-affinic radiosensitizers. Gräslund, A., Ehrenberg, A., Rupprecht, A. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1977) [Pubmed]
  17. The response of a transplantable tumor to fractionated irradiation. III. Fast neutrons plus the radiosensitizer Ro-07-0582. Denekamp, J., Morris, C., Field, S.B. Radiat. Res. (1977) [Pubmed]
  18. A comparison of radiation-sensitizing ability and cell uptake for NDPP and Ro-07-0582. Wong, T.W., Whitmore, G.F. Radiat. Res. (1977) [Pubmed]
  19. Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses. Dische, S., Saunders, M.I., Lee, M.E., Adams, G.E., Flockhart, I.R. Br. J. Cancer (1977) [Pubmed]
  20. The analgesic activity of imidazopyridine derivatives. Maruyama, Y., Anami, K., Katoh, Y. Arzneimittel-Forschung. (1978) [Pubmed]
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