Disease relevance of Ro 07-0582

• Modification of radiation responses of murine tumors by misonidazole (Ro 07-0582), host immune capability, and Corynebacterium parvum [1].
• RO-07-0582 toxicity studies were performed in 12 patients for a total of 16 assays [2].
• Interaction of hyperthermia and the hypoxic cell sensitizer Ro-07-0582 on the EMT6 mouse tumour [3].
• The subsequent incidence of distant metastases was not increased by the use of Ro-07-0582 at the time of "primary" tumour irradiation [4].
• No cytotoxicity in the tumour was observed when 1 mg/g body weight of Ro-07-0582 was injected immediately after a single dose of X-rays; indeed a small protective effect was seen [4].

High impact information on Ro 07-0582

• We investigated the use of combined S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721), misonidazole (Ro-07-0582) and single dose radiotherapy in treating the EMT 6/Ky tumor implanted in the buccal mucosa of Balb/c mice [5].
• The hypoxic-cell radiosensitizing drug misonidazole Ro-07-0582 (MISO) was administered i.v. to mature New Zealand White rabbits at a dose of 100 mg/kg, and the resulting drug concentrations in both blood and ear-cartilage samples measured by HPLC [6].
• Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine [7].
• In vitro, Ro-07-0582 in air at 37 degrees C does not cause loss of cell viability at concentrations up to 2 mM, even when in contact for several days [8].
• Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01 [7].

Biological context of Ro 07-0582

• Y-9213 (0.1--10 micrometer) also inhibited significantly the phagocytic secretion of lysosomal enzymes from PMN leukocytes without affecting phagocytosis of the particles [9].
• These findings indicate that miroprofen may be more effective in suppressing pain responses and acute inflammation accompanied with increased vascular permeability [10].

Anatomical context of Ro 07-0582

• Radiosensitization of mouse spermatogenic stem cells by Ro-07-0582 [11].
• Chemoradioprotection of the rat parotid gland by combined use of WR-2721 and Ro-07-0582 [12].
• These results suggest that Y-9213 inhibits the phagocytic secretion in vivo of lysosomal constituents from leukocytes [13].
• 2-(4-(2-Imidazo[1,2-a]pyridyl)phenyl)propionic acid (Y-9213) with analgesic, antipyretic and anti-inflammatory activities significantly inhibited hemolysis of rat erythrocytes [9].
• Our results suggest that Y-9213 may stabilize membranes of erythrocytes and lysosomes and inhibit phagocytic secretion of lysosomal constitutents from PMN leukocytes [9].

Associations of Ro 07-0582 with other chemical compounds

• The hypoxic cell-radiosensitizing drug misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxypropan -2 -ol, Ro 07-0582, MIS) was administered at a dose of 150 mg/kg i.v. to 6 dogs bearing spontaneous tumours, and the resulting tumour concentrations were measured to HPLC analysis [14].
• A comparison has been made of the effects of the 2-nitroimidazole Ro-07-0582 on tumour growth delay after irradiation and tumour cell survival in vitro after irradiation in vivo [15].
• Effects of 2-[4-(2-imidazo[1,2-a]pyridyl)phenyl] propionic acid (Y-9213) on in vivo release of lysosomal enzymes from rat polymorphonuclear leukocytes during phagocytosis of particles [13].
• Electron paramagnetic resonance (e.p.r.) was used to study the free radicals induced by gamma-irradiation at 77 K in oriented DNA with incorporated electronaffinic radiosensitizing compounds (4-nitroacetophenone, metronidazole, and Ro-07-0582) [16].

Gene context of Ro 07-0582

• The response of a transplantable tumor to fractionated irradiation. III. Fast neutrons plus the radiosensitizer Ro-07-0582 [17].
• A comparison of radiation-sensitizing ability and cell uptake for NDPP and Ro-07-0582 [18].

Analytical, diagnostic and therapeutic context of Ro 07-0582

• Although the total dose of Ro 07-0582 must be limited, there is a real prospect that it will give benefit in clinical radiotherapy [19].
• Y-9213 also showed an analgesia in the tail pinch and electric stimulation test [20].

References