Disease relevance of gamma-L-Glutamyltaurine

• Intra-amygdaloid injections of gamma-glutamyltaurine, a recently identified brain dipeptide, strongly suppressed seizures in amygdala-kindled rats stimulated with intensities 10 or 50 microA above the generalized seizure triggering threshold (mean 82 microA) [1].
• Glutaurine significantly decreased the incidence of hepatoma, but had no significant effect on the lethality of MC29/L infected birds [2].
• Correlative changes in the protein contents of haemolymph and fat body and the accumulation of protein storage granules in the fat body cells of Mamestra brassicae were investigated during the last larval stage in normally developing larvae and following administration of glutaurine (1 X 10(-4) mg/g body weight) [3].

Psychiatry related information on gamma-L-Glutamyltaurine

• Effects of glutaurine treatment on electroshock-induced amnesia. Antiamnesic action of glutaurine [4].
• The data indicate that glutaurine is able to prevent electroconvulsive shock-induced amnesia by counteracting the effect of the electroconvulsive shock on the memory consolidation phase, but it is less effective on learning or it is ineffective on retrieval processes [4].

High impact information on gamma-L-Glutamyltaurine

• We have examined whether gamma-L-glutamyl-taurine (Litoralon) could prevent the genotoxic action of mitomycin C (MMC) in the rat bone marrow cells using the micronucleus test [5].
• The effects of oral glutaurine (gamma-L-glutamyl-taurine, LitoralonR Chinoin, Budapest) treatment on electroconvulsive shock-induced amnesia were studied [4].
• The effect of glutaurine on thyroid hormones in the rat [6].
• Effect of glutaurine on plasma renin activity in the rat and the dog [7].
• Local mediated effects associate increased activity of excitatory neuromediators: acetylcholine, catecholamines and ionotropic - (NMDA and non-NMDA) - receptors of excitatory aminoacids (EAA), with decreased activity of inhibitory neuromediators: GABA, taurine, glutaurine, adenosine and K receptors of opioids [8].

Biological context of gamma-L-Glutamyltaurine

• Effect of treatment with glutaurine on human antibody-dependent cell-mediated cytotoxicity (ADCC) [9].
• Effect of litoralon (gamma-L-glutamyl-taurine) on the tail involution of tadpoles in vitro [10].
• The results suggest that glutaurine possesses a radiation protective effect in animals irradiated with LD50/30 of roentgen rays and 60Co gamma rays [11].

Anatomical context of gamma-L-Glutamyltaurine

• The inhibition of the selective uptake of haemolymphatic storage proteins by fat body following glutaurine treatment is suggested [3].
• Complex morphological study of the effect of glutaurine in mast cells [12].
• It is suggested that glutaurine increases the originally low spontaneous killer activity of tumor patients' lymphocytes through an indirect regulatory mechanism [13].
• The effect of glutaurine (gamma-L-glutamyl-taurine) on the division of rat thymus cells [14].
• Effect of glutaurine on the pineal gland of the rat [15].

Associations of gamma-L-Glutamyltaurine with other chemical compounds

• The peritoneal mast cells stain positively with safranin, swell excessively and assume bizarre forms in response to 5 micrograms/rat glutaurine intraperitoneally [12].
• Interaction of gamma-L-glutamyltaurine with kainate-induced cyclic AMP formation in the rat hippocampus [16].

Gene context of gamma-L-Glutamyltaurine

• Effect of glutaurine, a newly discovered parathyroid hormone on rat thymus cultures [17].
• The effects of in vitro and in vivo treatment with glutaurine, a newly discovered parathyroid hormone possessing immunostimulative activity, on human antibody-dependent cell-mediated cytotoxicity (ADCC) were studied in 15 tumor patients with healthy subjects in a xenogeneic test system using chicken erythrocytes as target cells [9].
• These inhibitory actions on ChAT activity by KA and Q were reversed by gamma-glutamyltaurine (GT) but not by 2-amino-5-phosphonopentanoic acid (AP5) [18].
• Glutaurine exerts moderate immunostimulating activity, but fails to influence the clinical course of systemic lupus erythematosus [19].

Analytical, diagnostic and therapeutic context of gamma-L-Glutamyltaurine

• Reverse transcriptase determinations in turkey fibroblast cell cultures indicated that glutaurine delays MC29/L virus expression [2].
• Treatment with PF-PTE or glutaurine prevented the development of hyperglycaemia induced by X-ray whole body irradiation with 154.8 or 219.3 or 258.0 mC/kg doses [20].

References