Disease relevance of n-Butene

• Mutagenicity of aryl propylene and butylene oxides with salmonella [1].
• The compounds had a slight growth inhibitory effect on colon cell carcinoma and melanoma cells in which case the butylene linker seemed to be more effective than the propylene linker [2].
• Only two compounds with the butylene [(CH2)4] linker (10, 12) were active against non-small lung cancer cells [3].
• High-level exposure to polybutene was lethal to three of four animals, due to pulmonary edema [4].
• The difference in the sensitivity of various renal cell carcinomas was significant: 5 lines were not sensitive, three of them (786-0, RXF-393 and TK-10) were sensitive to only butylene-substituted phenothiazine-ureas, propylene substitution resulted in ineffective compounds [2].

High impact information on n-Butene

• The alkylaminoethane side chain is essential for antiestrogenic activity, but the potency of the antiestrogen can be increased by para hydroxylation of the phenyl ring on carbon 1 of but-1-ene [5].
• Cyclic dinucleotides containing a butylene nucleobase-phophotriester connection are synthesised by a tandem ring-closing metathesis and hydrogenation reaction [6].
• A single methylene group between the receptor binding site and the half-sandwich complex gave an IC(50) of 217 nM for HT(1A), whereas a butylene linker resulted in retention of the inhibition constant with an IC(50) of 6 nM with respect to underivatized WAY [7].
• In order to identify the compound having the most appropriate pharmacokinetic properties as a potential melanoma imaging agent, thirteen new [125I]radioiodobenzamides with a butylene amide-amine spacer and various substituents on the terminal amino group were investigated [8].
• Cellular accumulation and retention of the technetium-99m-labelled hypoxia markers BRU59-21 and butylene amine oxime [9].

Chemical compound and disease context of n-Butene

• The addition of 50 mM sodium acetate to whey increased the production of butylene glycol and acetoin by Enterobacter aerogenes; it also increased the production of glycol by Klebsiella pneumoniae, but the increase in this case was offset by a decrease of production of acetoin [10].
• The two butylene linked phenothiazine ureas (10, 12) had moderate antiproliferative action on two renal cancer cell lines [3].

Biological context of n-Butene

• It is concluded that inhalation of the polybutene and one of the mineral cable oils tested here produces toxic effects in lung [4].
• Effects of butylene and propylene glycols on body composition and fatty acid synthetase in lambs [11].

Anatomical context of n-Butene

• The two derivatives with the butylene bridge were more effective than propylene linked compounds against the CCRP-CEM, HL60 (TB), K-562 and MOLT-4 cell lines [2].
• Elevated numbers of pulmonary macrophages and increased macrophage vacuolization were observed after exposure to the polybutene, both mineral oils, and one alkylbenzene [4].
• The results demonstrated that the main metabolic pathway in human liver S9 and liver microsomes involve oxidation at cyclohexane, oxidative cleavage of the butylene side chain and S-oxidation [12].

Associations of n-Butene with other chemical compounds

• Porous poly(ethylene glycol) terephthalate:poly (butylene terephthalate) (PEGT:PBT) scaffolds with high PEG molecular weight (1000 g/mole) and PEGT content (60%) were fabricated using two different processes-paraffin templating and compression molding-for cartilage engineering applications [13].
• Multiblock poly(ether-ester)s based on poly(ethylene glycol), butylene terephthalate, and butylene succinate segments were evaluated for their in vivo degradation and biocompatibility in order to establish a correlation with previously reported in vitro results [14].

Gene context of n-Butene

• On the other hand, only compound 5c with an acryloyl group and a butylene chain behaved like a 5-HT1A/5-HT2A antagonist [15].

References