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Chemical Compound Review

CHEMBL1250     1-methyl-3,7-dihydropurine- 2,6-dione

Synonyms: PubChem23793, SureCN10996, CPD-9025, CCRIS 5816, AG-L-63047, ...
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High impact information on CCRIS 5816


Biological context of CCRIS 5816


Anatomical context of CCRIS 5816

  • The metabolism of infused 1-methylxanthine (1-MX) to 1-methylurate (1-MU) by capillary endothelial xanthine oxidase of the constant-flow perfused rat hindlimb was shown previously to decrease with oxygen uptake (VO2) when nutritive flow was decreased [10].

Associations of CCRIS 5816 with other chemical compounds


Gene context of CCRIS 5816


Analytical, diagnostic and therapeutic context of CCRIS 5816


  1. Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. Vincent, M.A., Dawson, D., Clark, A.D., Lindner, J.R., Rattigan, S., Clark, M.G., Barrett, E.J. Diabetes (2002) [Pubmed]
  2. Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hindlimb. Rattigan, S., Wallis, M.G., Youd, J.M., Clark, M.G. Diabetes (2001) [Pubmed]
  3. Reductive half-reaction of xanthine oxidase with xanthine. Observation of a spectral intermediate attributable to the molybdenum center in the reaction of enzyme with xanthine. Kim, J.H., Hille, R. J. Biol. Chem. (1993) [Pubmed]
  4. Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulphamethoxazole in HIV-infected patients. Carr, A., Gross, A.S., Hoskins, J.M., Penny, R., Cooper, D.A. AIDS (1994) [Pubmed]
  5. Purification and characterization of caffeine synthase from tea leaves. Kato, M., Mizuno, K., Fujimura, T., Iwama, M., Irie, M., Crozier, A., Ashihara, H. Plant Physiol. (1999) [Pubmed]
  6. Expression of N-acetyltransferase (NAT) in cultured human uroepithelial cells. Kloth, M.T., Gee, R.L., Messing, E.M., Swaminathan, S. Carcinogenesis (1994) [Pubmed]
  7. Theophylline metabolism in human liver microsomes: inhibition studies. Tjia, J.F., Colbert, J., Back, D.J. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  8. Caffeine as a potential indicator for acetylator status. Rankin, R.B., Hudson, S.A., Fell, A.F. Journal of clinical pharmacy and therapeutics. (1987) [Pubmed]
  9. Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice. Nakatsuka, T., Hanada, S., Fujii, T. Teratology (1983) [Pubmed]
  10. Increased metabolism of infused 1-methylxanthine by working muscle. Youd, J.M., Newman, J.M., Clark, M.G., Appleby, G.J., Rattigan, S., Tong, A.C., Vincent, M.A. Acta Physiol. Scand. (1999) [Pubmed]
  11. Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways. Carrillo, J.A., Benítez, J. Clin. Pharmacol. Ther. (1994) [Pubmed]
  12. In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Sarkar, M., Polk, R.E., Guzelian, P.S., Hunt, C., Karnes, H.T. Antimicrob. Agents Chemother. (1990) [Pubmed]
  13. Relationship between in vivo acetylator phenotypes and cytosolic N-acetyltransferase and O-acetyltransferase activities in human uroepithelial cells. Frederickson, S.M., Messing, E.M., Reznikoff, C.A., Swaminathan, S. Cancer Epidemiol. Biomarkers Prev. (1994) [Pubmed]
  14. T-1032, a cyclic GMP phosphodiesterase-5 inhibitor, acutely blocks physiologic insulin-mediated muscle haemodynamic effects and glucose uptake in vivo. Mahajan, H., Richards, S.M., Rattigan, S., Clark, M.G. Br. J. Pharmacol. (2003) [Pubmed]
  15. In vivo and in vitro 1-methylxanthine metabolism in the rat. Evidence that the dehydrogenase form of xanthine oxidase predominates in intact perfused liver. Reinke, L.A., Nakamura, M., Logan, L., Christensen, H.D., Carney, J.M. Drug Metab. Dispos. (1987) [Pubmed]
  16. Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment. Nyéki, A., Biollaz, J., Kesselring, U.W., Décosterd, L.A. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
  17. The effect of RPR 102341 on theophylline metabolism and phenacetin O-deethylase activity in human liver microsomes. White, R.B., Heyn, H., Stevens, J.C. Pharm. Res. (1997) [Pubmed]
  18. Regulation of glycogen in the dentate gyrus of the in vitro guinea pig hippocampus; effect of combined deprivation of glucose and oxygen. Lipton, P. J. Neurosci. Methods (1989) [Pubmed]
  19. The use of caffeine as a metabolic probe for human drug metabolizing enzymes. Miners, J.O., Birkett, D.J. Gen. Pharmacol. (1996) [Pubmed]
  20. Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping. Wong, P., Banerjee, K., Massengill, J., Nowell, S., Lang, N., Leyland-Jones, B. J. Immunol. Methods (2001) [Pubmed]
  21. Determination of acetylator phenotype in Caucasians with caffeine. Hildebrand, M., Seifert, W. Eur. J. Clin. Pharmacol. (1989) [Pubmed]
  22. Serotonin inhibition of 1-methylxanthine metabolism parallels its vasoconstrictor activity and inhibition of oxygen uptake in perfused rat hindlimb. Rattigan, S., Appleby, G.J., Miller, K.A., Steen, J.T., Dora, K.A., Colquhoun, E.Q., Clark, M.G. Acta Physiol. Scand. (1997) [Pubmed]
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