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Chemical Compound Review

MeDNJ     (2R,3R,4R,5S)-2- (hydroxymethyl)-1-methyl...

Synonyms: NMDNJ, N-Methyl-DNJ, Mor-14, CHEMBL75971, MOR 14, ...
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High impact information on N-METHYLDEOXYNOJIRIMYCIN






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Analytical, diagnostic and therapeutic context of N-METHYLDEOXYNOJIRIMYCIN


  1. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly reduced infarct size in rabbit hearts. Arai, M., Minatoguchi, S., Takemura, G., Uno, Y., Kariya, T., Takatsu, H., Fujiwara, T., Higashioka, M., Yoshikuni, Y., Fujiwara, H. Circulation (1998) [Pubmed]
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  3. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. Nishida, Y., Minatoguchi, S., Arai, M., Takemura, G., Uno, Y., Hashimoto, K., Wang, N., Chen, X.H., Fujiwara, T., Fujiwara, H. Heart and vessels. (2000) [Pubmed]
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  6. The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth. Pili, R., Chang, J., Partis, R.A., Mueller, R.A., Chrest, F.J., Passaniti, A. Cancer Res. (1995) [Pubmed]
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  8. Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor. Arai, M., Minatoguchi, S., Kumada, H., Uno, Y., Nishida, Y., Hashimoto, K., Wang, N., Takemura, G., Fujiwara, T., Higashioka, M., Kuwano, K., Fujiwara, H. Br. J. Pharmacol. (2001) [Pubmed]
  9. Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo. Faber, E.D., Oosting, R., Neefjes, J.J., Ploegh, H.L., Meijer, D.K. Pharm. Res. (1992) [Pubmed]
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  11. Different effects of the glucosidase inhibitors 1-deoxynojirimycin, N-methyl-1-deoxynojirimycin and castanospermine on the glycosylation of rat alpha 1-proteinase inhibitor and alpha 1-acid glycoprotein. Gross, V., Tran-Thi, T.A., Schwarz, R.T., Elbein, A.D., Decker, K., Heinrich, P.C. Biochem. J. (1986) [Pubmed]
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  14. Expression of choline acetyltransferase activity in a co-culture of spinal cord and skeletal muscle cells is inhibited by myogenic differentiation inhibitors. Kengaku, M., Kawashima, S., Nakane, M. Brain Res. Dev. Brain Res. (1991) [Pubmed]
  15. Evidence for processing of dolichol-linked oligosaccharides in patients with neuronal ceroid-lipofuscinosis. Daniel, P.F., Sauls, D.L., Boustany, R.M. Am. J. Med. Genet. (1992) [Pubmed]
  16. Effect of inhibitors of N-linked oligosaccharide processing on the cell surface expression of a melanoma integrin. Spiro, R.C., Laufer, D.M., Perry, S.K., Harper, J.R. J. Cell. Biochem. (1989) [Pubmed]
  17. Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits. Wu, D.J., Minatoguchi, S., Uno, Y., Arai, M., Wang, N., Nishida, Y., Hashimoto, K., Hashimoto, Y., Takemura, G., Fujiwara, T., Fujiwara, H. Jpn. Circ. J. (2001) [Pubmed]
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