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Chemical Compound Review

BNPS-skatol     3-bromo-3-methyl-2-(2- nitrophenyl)sulfanyl...

Synonyms: Bnps-skatole, BIM105, SureCN168417, B4651_SIGMA, NSC-240875, ...
 
 
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Disease relevance of NSC 240875

 

High impact information on NSC 240875

  • The amino acid sequence of the light chain of bovine protein C was determined by sequenator analysis of the carboxymethylated light chain and fragments obtained by cyanogen bromide treatment, tryptic digestion after blocking of lysine residues, and cleavage with 2-(2-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine (BNPS-skatole) [5].
  • The complete amino acid sequence of bovine bone matrix Gla protein (MGP) was determined by automatic sequence analysis of the intact protein and of peptides isolated from tryptic and BNPS-skatole digests [6].
  • Examination of the catalytic core of PAL (PALcc) using trypsin, BNPS skatole, and COOH-terminally truncated proteins failed to identify stable subdomains [7].
  • BNPS-skatole cleavages of [3H]-25-OH-D3-3-BE- and 3H-1alpha,25(OH)2D3-3-BE-labeled DBP samples produced the same labeled peptide (N-terminal), demonstrating the specificity of labeling by these analogs [8].
  • The C-terminal half of the bovine myelin basic protein, peptide 89-169, was treated with BNPS-skatole [2-(2-nitrophenylsulfenyl)-3-methyl-3'-bromoindolenine], and the products were isolated by repeated gel filtration through Sephadex G-50 [9].
 

Biological context of NSC 240875

  • Chemical degradation experiments were undertaken in an effort to produce identifiable fragments to which these signals could be assigned, including full and partial acid hydrolysis and tryptophan-targeted BNPS-skatole treatment [10].
 

Anatomical context of NSC 240875

 

Associations of NSC 240875 with other chemical compounds

 

Gene context of NSC 240875

 

Analytical, diagnostic and therapeutic context of NSC 240875

References

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  2. The complete amino acid sequence of the mature form of rat sepiapterin reductase. Oyama, R., Katoh, S., Sueoka, T., Suzuki, M., Ichinose, H., Nagatsu, T., Titani, K. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  3. The isolation and characterisation of human atrial natriuretic factor produced as a fusion protein in Escherichia coli. Knott, J.A., Sullivan, C.A., Weston, A. Eur. J. Biochem. (1988) [Pubmed]
  4. Peptide mapping and amino acid sequencing of two catechol 1,2-dioxygenases (CD I1 and CD I2) from Acinetobacter lwoffii K24. Kim, S.I., Ha, K.S. Mol. Cells (1997) [Pubmed]
  5. Bovine protein C: amino acid sequence of the light chain. Fernlund, P., Stenflo, J., Tufvesson, A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  6. Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. Price, P.A., Williamson, M.K. J. Biol. Chem. (1985) [Pubmed]
  7. Essential features of the catalytic core of peptidyl-alpha-hydroxyglycine alpha-amidating lyase. Kolhekar, A.S., Bell, J., Shiozaki, E.N., Jin, L., Keutmann, H.T., Hand, T.A., Mains, R.E., Eipper, B.A. Biochemistry (2002) [Pubmed]
  8. Roles of the structure and orientation of ligands and ligand mimics inside the ligand-binding pocket of the vitamin D-binding protein. Swamy, N., Dutta, A., Ray, R. Biochemistry (1997) [Pubmed]
  9. Reaction of peptide 89-169 of bovine myelin basic protein with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-bromoindolenine. Martenson, R.E., Deibler, G.E., Kramer, A.J. Biochemistry (1977) [Pubmed]
  10. Morulin Pm: a modified polypeptide containing TOPA and 6-bromotryptophan from the morula cells of the ascidian, Phallusia mammillata. Taylor, S.W., Kammerer, B., Nicholson, G.J., Pusecker, K., Walk, T., Bayer, E., Scippa, S., de Vincentiis, M. Arch. Biochem. Biophys. (1997) [Pubmed]
  11. The apoprotein of the major rat brain myelin P7 proteolipid: alignment of the BNPS-skatole fragments and present state of the sequence. Nussbaum, J.L., Jollès, J., Jollès, P. Biochimie (1982) [Pubmed]
  12. Chemical cleavage of bovine rhodopsin at tryptophanyl bonds; characterization of the polypeptide fragments and the phosphorylated site. Pellicone, C., Virmaux, N., Nullans, G., Mandel, P. Biochimie (1981) [Pubmed]
  13. Insights into a conformational epitope of Hev b 6.02 (hevein). Reyes-López, C.A., Hernández-Santoyo, A., Pedraza-Escalona, M., Mendoza, G., Hernández-Arana, A., Rodríguez-Romero, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  14. Chemical cleavage of bovine beta-lactoglobulin by BNPS-skatole for preparative purposes: comparative study of hydrolytic procedures and peptide characterization. Rahali, V., Gueguen, J. J. Protein Chem. (1999) [Pubmed]
  15. The amino acid sequence of the glycosylated amyloid immunoglobulin light chain protein AL MS. Omtvedt, L.A., Husby, G., Cornwell, G.G., Kyle, R.A., Sletten, K. Scand. J. Immunol. (1997) [Pubmed]
  16. Sequence homology analysis of proteins by chemical cleavages: using a mono and two dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Han, K.K., Richard, C., Zhang, G.Y., Delacourte, A. Int. J. Biochem. (1986) [Pubmed]
  17. Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae. Correia, H., Medina, R., Hernández, A., Bustamante, E., Chakraburtty, K., Herrera, F. Mem. Inst. Oswaldo Cruz (2004) [Pubmed]
  18. The amino acid sequence of serum amyloid A (SAA) protein in mink. Syversen, V., Sletten, K., Marhaug, G., Husby, G., Lium, B. Scand. J. Immunol. (1987) [Pubmed]
  19. Complete amino acid sequence of ostrich (Struthio camelus) egg-white lysozyme, a goose-type lysozyme. Schoentgen, F., Jollès, J., Jollès, P. Eur. J. Biochem. (1982) [Pubmed]
  20. Purification of a 24 kD parasitism-specific hemolymph protein from pharate pupae of the Caribbean fruit fly, Anastrepha suspensa. Rolle, R.S., Lawrence, P.O. Arch. Insect Biochem. Physiol. (1994) [Pubmed]
  21. Peptides and autoimmune disease. Eylar, E.H. Adv. Exp. Med. Biol. (1978) [Pubmed]
  22. Applications of chemical cleavage procedures to the peptide mapping of neurofilament triplet protein bands in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Mahboub, S., Richard, C., Delacourte, A., Han, K.K. Anal. Biochem. (1986) [Pubmed]
  23. Fragments of myelin basic protein derived from human brain are not mitogenic in cultures of human amniotic fluid cells and other cells. Addison, G.M., Jackson, P., Snape, B.M., Thompson, R.J. Horm. Metab. Res. (1984) [Pubmed]
 
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