Disease relevance of DIETHYL ETHER

• Lymphoma development was completely inhibited by inactivation of cell-free pellets from Si-IIA culture with ethyl ether and was almost suppressed by neutralization of the cell-free pellets with anti-Si-IIA sera [1].
• One leads to (a) picropodophyllin (2), which undergoes dehydration to give alpha-apopicropodophyllin (5), which rearranges to give beta-apopicropodophyllin (6), (b) the ethyl ether of picropodophyllotoxin, 8, and (c) the ethyl ether of epipicropodophyllotoxin, 7 [2].
• Short-term oral toxicity of butyl ether, ethyl hexyl ether, methyl heptyl ether and 1,6-dimethoxyhexane in male rats and the role of 2-methoxyacetic acid [3].
• Hair lotion dermatitis with sensitization to d-panthenyl ethyl ether [4].
• Other anesthetics either do not produce hypnosis (Veronal), do not have a prolonged enough effect (ethyl ether, chloroform), or induce vasodilatation, which prevents hypertrophy (MS-222, urethane) [5].

Psychiatry related information on DIETHYL ETHER

• Our results indicate that perinatal exposure to ethyl ether during the critical period of male brain sexual differentiation, acting as endocrine disruptors, has a long-term effect on the fertility and sexual behavior of male rats, suggesting endocrine disruption through incomplete masculinization and defeminization of the central nervous system [6].

High impact information on DIETHYL ETHER

• Apoprotein E, isolated after delipidization of lipoproteins with either methyl ethyl ketone or ethanol and ethyl ether, was immunosuppressive [7].
• Thus, erythromycin B enol ether ethyl succinate is very poorly soluble in water, and its hydrolysis is undetectable in conditions resembling the medicine bottle [8].
• Reaction of adenosine with an excess of BM in phosphate buffer (pH 7.4) at 37 degrees C, followed by extraction of the reaction mixture with ethyl ether to remove excess unreacted BM and incubation at 80 degrees C for 1 h, resulted in complete conversion of N1-adenosine adducts to the corresponding N6-adenosine and N1-inosine adducts [9].
• Tracheal epithelium of mice anesthetized with ethyl ether was studied in the electron microscope with the techniques of thin sectioning and freeze fracture [10].
• After acidification of the reaction medium, the products were extracted with ethyl ether, converted to their methyl esters, and characterized using HPLC [11].

Chemical compound and disease context of DIETHYL ETHER

• alpha, beta-Arteether is an ethyl ether derivative of artemisinin which is an efficient schizontocidal drug in mild falciparum malaria [12].
• A signal peptide, a processing product of the precursor of the lipoprotein in the cytoplasmic membrane of Escherichia coli, has been purified through extractions with butanol and ethyl ether and chromatographies with a Sephadex LH-60 column and Sep-pak C18 [13].
• The aim of the present work was to study the antioxidant activity of the new derivative of succinic acid-succinate mono[(2-dimethyl-amino) ethyl ether] of succinic acid (yackton) under conditions of hypoxic and hemic hypoxia as well as to examine in vitro the antiradical activity of this preparation [14].
• Tetany occurred in less than 50 percent of one group of dogs made alkalotic by hyperventilation or made hypocalcemic by infusion of ethylene glycol-bis(beta-amino ethyl ether) N, N'-tetraacetate [15].

Biological context of DIETHYL ETHER

• There is, however, no measurable activity for dealkylation of retinyl ethyl ether or retinyl butyl ether [16].
• However, the ethyl ether extract obtained from the reaction mixture of furfural and nitrate with hydrochloric acid exhibited strong mutagenic activities toward S. typhimurium strains TA98 and TA100 in the presence of metabolic activation [17].
• Effects of inhalation of ethyl-ether on glycemia and on some variables of intermediate metabolism in rats [18].
• At the end of periods of 90, 180 and 270 days of treatment, the animals were anaesthetized with ethyl ether during estrus, weighed and sacrificed [19].
• We investigated the effects of an inhalatory anesthetic (ethyl ether) during the neonatal period of brain sexual differentiation on the later fertility and sexual behavior of male rats [6].

Anatomical context of DIETHYL ETHER

• Ethyl-oxide effects on a newly formed blood-brain barrier [20].
• A triacyglycerol lipase (EC 3.1.1.3) was purifiec about 60-fold from rat liver cytosol by delipidation with acetone and ethyl ether, hydroxyapatitie and Sephadex G-100 column chromatographies and isoelectrofocusing electrophoresis [21].
• On the other hand, the cytotoxicity of each fraction, which was evaluated by the MTT assay using human cancer cell lines (HT-29, HRT-18 and HepG2), was greatest in fraction III, which was extracted with a 7:3 petroleum ether and ethyl ether mixture [22].
• The morphofunctional effects of ethyl-oxide, utilized as anaesthetic, on the optic tectum blood-brain barrier were investigated in hatching chick embryos (21st incubation day) and young chickens in which the barrier to the marker of vascular permeability horseradish peroxidase is complete after the 18th incubation day [20].
• The antidiuretic factor in bovine choroid plexus was concentrated 100 times by extraction with acetic acid, fractional precipitation with acetone and ethyl ether, gel filtration, and paper chromatography [23].

Associations of DIETHYL ETHER with other chemical compounds

• Sterol IV was prepared by oxidation of the delta 8,14 dienol ethyl ether of the 3 beta-acetate of II with m-chloroperbenzoic acid, followed by mild alkaline hydrolysis of the 3 beta-acetate derivative of IV [24].
• 1. Partition of furosemide into organic solvents at pH 3.8 was greatest for ethyl acetate (33:1) greater than 2-ethyl-1-hexanol (10:1) greater than ethyl ether (6:1) [25].
• The unsaponifiable lipid matter was extracted with ethyl ether, and the class of 4,4-desmethylsterols (sterols) plus the triterpene diols (diols) erythrodiol, uvaol, and betulinol were isolated by thin-layer chromatography [26].
• Samples deproteinized with cold acetone were extracted, in acidic medium, with ethyl ether (peroxide free); after centrifugation, the aqueous phase was used for amino acid derivatization at 40 degrees C for 15 h with 1-fluoro-2,4-dinitrobenzene in bicarbonate-buffered medium [27].
• The method involved a diethyl ether-ethyl acetate (50:50, v/v) mixture extraction at pH 7 with acitretin and 13-cis-acitretin as internal standards [28].

Gene context of DIETHYL ETHER

• Via the in vitro PLA2 inhibitor assay, it was shown that the ethyl ether extract of the medium contained significant PLA2 inhibitor activity [29].
• Amebic cysteine protease 2 (EhCP2) was purified from ethyl ether extracts of axenically grown trophozoites of Entamoeba histolytica strain HM1-IMSS [30].
• The sensitive component induced by f(2) levels below 65 dB SPL is selectively affected by application of ethyl ether and disappears more quickly than the high-level component during ongoing deterioration of the moth preparation [31].
• Two experimental designs were used: First, either 12.5, 25 or 50 micrograms ethyleneglycol-bis-(beta-amino ethyl ether) N,N'-tetra-acetic acid (EGTA), or 25 or 50 micrograms verapamil, both dissolved in an artificial CSF vehicle, were infused ICV at the same time as ethanol's administration [32].
• The biodegradation sequence of the target compounds by the mixed culture, in order of removal rate, was toluene, ethyl benzene, p-xylene, benzene, MTBE, ethyl ether, tert-amyl methyl ether, and ethyl tert-butyl ether [33].

Analytical, diagnostic and therapeutic context of DIETHYL ETHER

• Short-chain fatty acids from the socks and feet of subjects either with strong foot odour or with weak or no foot odour were extracted with ethyl ether, and then analysed by gas chromatography/mass spectrometry (GC/MS) [34].
• Peptides and steroids were measured by RIA after FF extraction with liquid chromatography and ethyl-ether, respectively [35].
• Ovariectomy was performed under ethyl ether anesthesia [36].
• Tissue samples were extracted with ethyl ether and extracts were cleaned up by gel permeation chromatography and silica gel chromatography [37].
• However, the sleeping time induced by ethyl ether was not modified by the oral administration of the extract, not confirming the putative sedative effect of the plant [38].

References