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Chemical Compound Review

Halotestin     (8S,9S,10S,11S,13S,14S,17S)- 9-fluoro-11,17...

Synonyms: Testoral, Androxy, Flusteron, Flutestos, Oratestin, ...
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Disease relevance of Halotestin


High impact information on Halotestin


Chemical compound and disease context of Halotestin


Biological context of Halotestin


Anatomical context of Halotestin


Associations of Halotestin with other chemical compounds


Gene context of Halotestin

  • PRL levels were unaltered during fluoxymesterone treatment.(ABSTRACT TRUNCATED AT 250 WORDS)[22]
  • Acute and chronic stimulation of ACTH confirmed the adrenal origin of DHA, while the results of hCG stimulation test and fluoxymesterone suppression test assessed the testicular participation to the DHA production [28].
  • Thirteen children, ages 4 years 3 months to 13 years 7 months, were given hGH concomitant with fluoxymesterone in an intermittent regimen [5].
  • Prostate cancer developed in two male patients being treated with fluoxymesterone for erectile impotence [29].
  • Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52 [30].

Analytical, diagnostic and therapeutic context of Halotestin


  1. Evaluation of tamoxifen doses with and without fluoxymesterone in advanced breast cancer. Tormey, D.C., Lippman, M.E., Edwards, B.K., Cassidy, J.G. Ann. Intern. Med. (1983) [Pubmed]
  2. Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia. Loprinzi, C.L., Kugler, J.W., Sloan, J.A., Mailliard, J.A., Krook, J.E., Wilwerding, M.B., Rowland, K.M., Camoriano, J.K., Novotny, P.J., Christensen, B.J. J. Clin. Oncol. (1999) [Pubmed]
  3. Treatment of anemia in myeloproliferative disorders: a randomized study of fluoxymesterone v transfusions only. Brubaker, L.H., Brière, J., Laszlo, J., Kraut, E., Landaw, S.A., Peterson, P., Goldberg, J., Donovan, P. Arch. Intern. Med. (1982) [Pubmed]
  4. Ataxia caused by fluoxymesterone therapy in breast cancer. Agrawal, B.L. Arch. Intern. Med. (1981) [Pubmed]
  5. Growth increments with low dose intermittent growth hormone and fluoxymesterone in first year of therapy in hypopituitarism. Kirkland, R.T., Clayton, G.W. Pediatrics (1979) [Pubmed]
  6. A comparison of androgens for anemia in patients on hemodialysis. Neff, M.S., Goldberg, J., Slifkin, R.F., Eiser, A.R., Calamia, V., Kaplan, M., Baez, A., Gupta, S., Mattoo, N. N. Engl. J. Med. (1981) [Pubmed]
  7. Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma. Dilley, W.G., Leight, G.S., Silva, J.S., Ammirata, S., Haagensen, D.E., Wells, S.A. J. Natl. Cancer Inst. (1983) [Pubmed]
  8. The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men. Morley, J.E., Sawin, C.T., Carlson, H.E., Longcope, C., Hershman, J.M. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  9. Effect of fluoxymesterone on the pituitary-gonadal axis: the role of testosterone-estradiol-binding globulin. Vigersky, R.A., Easley, R.B., Loriaux, D.L. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  10. Androgen therapy in myelodysplastic syndromes with thrombocytopenia: a report on 20 cases. Wattel, E., Cambier, N., Caulier, M.T., Sautière, D., Bauters, F., Fenaux, P. Br. J. Haematol. (1994) [Pubmed]
  11. A randomized phase II trial of aminoglutethimide and hydrocortisone versus combined aminoglutethimide, hydrocortisone and fluoxymesterone in advanced breast cancer. Gennatas, C.S., Kalovidouris, A., Paraskevas, G.A., Kouvaris, J., Trichopoulos, D., Papavasiliou, C. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1987) [Pubmed]
  12. Combined endocrine treatment of elderly postmenopausal patients with metastatic breast cancer. A randomized trial of tamoxifen vs. tamoxifen + aminoglutethimide and hydrocortisone and tamoxifen + fluoxymesterone in women above 65 years of age. Rose, C., Kamby, C., Mouridsen, H.T., Andersson, M., Bastholt, L., Møller, K.A., Andersen, J., Munkholm, P., Dombernowsky, P., Christensen, I.J. Breast Cancer Res. Treat. (2000) [Pubmed]
  13. Effect of training and anabolic-androgenic steroids on drug metabolism in rat liver. Saborido, A., Molano, F., Megías, A. Medicine and science in sports and exercise. (1993) [Pubmed]
  14. Fluoxymesterone and the development of sexual behavior in the golden hamster. Vomachka, A.J., Clemens, L.G. Developmental psychobiology. (1981) [Pubmed]
  15. Treating the subfertile male patient: improvement semen characteristics after low dose androgen therapy. Urry, R.L., Cockett, A.T. J. Urol. (1976) [Pubmed]
  16. Influence of fluoxymesterone on in vitro erythropoiesis affected by leukemic cells. Bai, G.Z., Hara, H., Nagai, K. Exp. Hematol. (1984) [Pubmed]
  17. Liquid chromatographic assay for fluoxymesterone in human serum with application to a preliminary bioavailability study. Capponi, V.J., Cox, S.R., Harrington, E.L., Wright, C.E., Antal, E.J., Albert, K.S. Journal of pharmaceutical sciences. (1985) [Pubmed]
  18. In vitro and in vivo genotoxicity of hormonal drugs. VI. Fluoxymesterone. Dhillon, V.S., Singh, J., Singh, H., Kler, R.S. Mutat. Res. (1995) [Pubmed]
  19. Effect of anabolic steroids on mitochondria and sarcotubular system of skeletal muscle. Saborido, A., Vila, J., Molano, F., Megías, A. J. Appl. Physiol. (1991) [Pubmed]
  20. Stimulatory effects of androgens on normal children's bone marrow in culture: effects on BFU-E, CFU-E, and uroporphyrinogen I synthase activity. Claustres, M., Sultan, C. Horm. Res. (1986) [Pubmed]
  21. Fluoxymesterone-induced inclusion bodies in dog liver. Muraoka, Y. Exp. Mol. Pathol. (1982) [Pubmed]
  22. Effect of non aromatizable androgens on LHRH and TRH responses in primary testicular failure. Spitz, I.M., Margalioth, E.J., Yeger, Y., Livshin, Y., Zylber-Haran, E., Shilo, S. Horm. Metab. Res. (1984) [Pubmed]
  23. Androgen-induced remissions after antiestrogen and hypophysectomy in stage IV breast cancer. Manni, A., Arafah, B.M., Pearson, O.H. Cancer (1981) [Pubmed]
  24. Steroids and hematopoiesis. II. The effect of steroids on in vitro erythroid colony growth: evidence for different target cells for different classes of steroids. Singer, J.W., Adamson, J.W. J. Cell. Physiol. (1976) [Pubmed]
  25. Clinical study on estramustine binding protein (EMBP) in human prostate. Shiina, H., Igawa, M., Ishibe, T. Prostate (1996) [Pubmed]
  26. Screening of free 17-alkyl-substituted anabolic steroids in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. Leinonen, A., Kuuranne, T., Kotiaho, T., Kostiainen, R. Steroids (2004) [Pubmed]
  27. Determination of fluoxymesterone, norethandrolone, prednisolone, and prednisone in tablets by differential pulse polarography. Yadav, R.N., Teare, F.W. Journal of pharmaceutical sciences. (1978) [Pubmed]
  28. Unconjugated dehydroepiandrosterone plasma levels in normal subjects from birth to adolescence in human: the use of a sensitive radioimmunoassay. de Peretti, E., Forest, M.G. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  29. Impotence therapy and cancer of the prostate. Guinan, P.D., Sadoughi, W., Alsheik, H., Ablin, R.J., Alrenga, D., Bush, I.M. Am. J. Surg. (1976) [Pubmed]
  30. Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52. Ingle, J.N., Suman, V.J., Mailliard, J.A., Kugler, J.W., Krook, J.E., Michalak, J.C., Pisansky, T.M., Wold, L.E., Donohue, J.H., Goetz, M.P., Perez, E.A. Breast Cancer Res. Treat. (2006) [Pubmed]
  31. Androgen priming and response to chemotherapy in advanced prostatic cancer. Manni, A., Santen, R.J., Boucher, A.E., Lipton, A., Harvey, H., Simmonds, M., White-Hershey, D., Gordon, R.A., Rohner, T.J., Drago, J. J. Urol. (1986) [Pubmed]
  32. Radioimmunoassay for fluoxymesterone (Halotestin). Colburn, W.A. Steroids (1975) [Pubmed]
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