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Gene Review

ZBTB33  -  zinc finger and BTB domain containing 33

Homo sapiens

Synonyms: KAISO, Transcriptional regulator Kaiso, WUGSC:H_DJ525N14.1, ZNF-kaiso, ZNF348, ...
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Disease relevance of ZBTB33


Psychiatry related information on ZBTB33

  • To investigate the potential association of Kaiso disfunction with pathogenesis of Rett syndrome, we approached the analysis at two different levels [3].

High impact information on ZBTB33


Chemical compound and disease context of ZBTB33


Biological context of ZBTB33

  • CTCF DNA binding is methylation sensitive, and the methylated Rb-CTCF site is recognized by the Kaiso methyl-CpG-binding protein [7].
  • This is the first evidence suggesting that CTCF protects the Rb gene promoter, a classic CpG island, against DNA methylation, and when such control region is abnormally methylated Kaiso, and probably its associated repressor complex, induce epigenetic silencing of the promoter [7].
  • Further analysis ascertained that this CpG is contained in a sequence characterized by putative binding sites for the AP2, Sp1 and KAISO factors [8].
  • One of the major goals in this study was to assess the differential gene expression of p120(ctn), Kaiso, and VE-cadherin in HCAEC at specific locations along the wound border to further our understanding of the molecular mechanisms involved in wound closure [9].
  • A key component of the activity is Kaiso, a protein with POZ and zinc-finger domains that is known to associate with p120 catenin [4].

Anatomical context of ZBTB33


Associations of ZBTB33 with chemical compounds

  • Here we demonstrate that Kaiso, a methyl CpG binding protein belonging to the BTB/POZ family of transcription factors, is a component of the human N-CoR complex [5].
  • Kaiso is a bimodal transcription factor that recognizes methylated CpG dinucleotides or a conserved unmethylated sequence (TNGCAGGA, the Kaiso binding site) [12].
  • The mutation of one positively charged lysine to alanine in the NLS of full-length Kaiso significantly inhibited its nuclear localization in various cell types [13].

Other interactions of ZBTB33

  • Detection of p120(ctn), Kaiso, and VE-cadherin mRNA was carried out using quantitative real time PCR [9].
  • Quantitative real time PCR analysis revealed p120(ctn):GAPDH ratios, Kaiso: GAPDH ratios, and VE-cadherin:GAPDH ratios, relative to static control for each set, of 0.99-4.18 (mean +/- S.E., 1.94 +/- 0.404), 1.0-5.24 (2.11 +/- 0.51), and 0.99-1.42 (1.09 +/- 0.09) after 3 h of LSS, respectively [9].
  • In vivo, Kaiso targets the N-CoR complex to the MTA2 gene promoter in a methylation-dependent manner [5].

Analytical, diagnostic and therapeutic context of ZBTB33


  1. Regulation of the rapsyn promoter by kaiso and delta-catenin. Rodova, M., Kelly, K.F., VanSaun, M., Daniel, J.M., Werle, M.J. Mol. Cell. Biol. (2004) [Pubmed]
  2. A role for Kaiso-p120ctn complexes in cancer? van Roy, F.M., McCrea, P.D. Nat. Rev. Cancer (2005) [Pubmed]
  3. The X-linked methyl binding protein gene Kaiso is highly expressed in brain but is not mutated in Rett syndrome patients. Della Ragione, F., Tiunova, A., Vacca, M., Strazzullo, M., González, E., Armstrong, J., Valero, R., Campanile, C., Pineda, M., Hulten, M., Monros, E., D'Esposito, M., Prokhortchouk, E. Gene (2006) [Pubmed]
  4. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Prokhortchouk, A., Hendrich, B., Jørgensen, H., Ruzov, A., Wilm, M., Georgiev, G., Bird, A., Prokhortchouk, E. Genes Dev. (2001) [Pubmed]
  5. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Yoon, H.G., Chan, D.W., Reynolds, A.B., Qin, J., Wong, J. Mol. Cell (2003) [Pubmed]
  6. A family of human zinc finger proteins that bind methylated DNA and repress transcription. Filion, G.J., Zhenilo, S., Salozhin, S., Yamada, D., Prokhortchouk, E., Defossez, P.A. Mol. Cell. Biol. (2006) [Pubmed]
  7. Epigenetic regulation of the human retinoblastoma tumor suppressor gene promoter by CTCF. De La Rosa-Velázquez, I.A., Rincón-Arano, H., Benítez-Bribiesca, L., Recillas-Targa, F. Cancer Res. (2007) [Pubmed]
  8. The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon. Arányi, T., Faucheux, B.A., Khalfallah, O., Vodjdani, G., Biguet, N.F., Mallet, J., Meloni, R. J. Neurochem. (2005) [Pubmed]
  9. Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. Kondapalli, J., Flozak, A.S., Albuquerque, M.L. J. Biol. Chem. (2004) [Pubmed]
  10. Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment. Soubry, A., van Hengel, J., Parthoens, E., Colpaert, C., Van Marck, E., Waltregny, D., Reynolds, A.B., van Roy, F. Cancer Res. (2005) [Pubmed]
  11. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. Daniel, J.M. Biochim. Biophys. Acta (2007) [Pubmed]
  12. The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso. Defossez, P.A., Kelly, K.F., Filion, G.J., Pérez-Torrado, R., Magdinier, F., Menoni, H., Nordgaard, C.L., Daniel, J.M., Gilson, E. J. Biol. Chem. (2005) [Pubmed]
  13. Nuclear import of the BTB/POZ transcriptional regulator Kaiso. Kelly, K.F., Otchere, A.A., Graham, M., Daniel, J.M. J. Cell. Sci. (2004) [Pubmed]
  14. Monoclonal antibodies to Kaiso: a novel transcription factor and p120ctn-binding protein. Daniel, J.M., Ireton, R.C., Reynolds, A.B. Hybridoma (2001) [Pubmed]
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