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Gene Review

CTNND1  -  catenin (cadherin-associated protein),...

Homo sapiens

Synonyms: CAS, CTNND, Cadherin-associated Src substrate, Catenin delta-1, KIAA0384, ...
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Disease relevance of CTNND1

  • p120-catenin expression in human colorectal cancer [1].
  • Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells [2].
  • In this study, we have evaluated the expression of alpha-catenin but also of the other catenins (beta-, gamma- and p120-catenin) and E-cadherin in invasive breast cancer and statistically analysed these expressions with known clinicopathological parameters, c-erbB-2 oncoprotein expression and patient survival [3].
  • Inducible expression of p120Cas1B isoform corroborates the role for p120-catenin as a positive regulator of E-cadherin function in intestinal cancer cells [4].
  • Eight adult cases with myeloperoxidase anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA)-related (pauci-immune type) crescentic glomerulonephritis were examined on immunofluorescence microscopy with anti-pan cadherin, p120 catenin, and beta-catenin antibodies [5].
  • Membranous p120 is maintained in invasive squamous cell carcinomas in tumours suggesting that p120 may be important for the collective invasion of tumours cells in vivo [6].
  • The data indicate that the increased expression of p120 isoform 1 during tumor progression contributes to the invasive phenotype of cadherin-deficient carcinomas and that the N-terminal domain of p120 is a valid therapeutic target [7].

High impact information on CTNND1

  • Although p120-catenin regulates adherens junction (AJ) stability in cultured cells, genetic studies in lower eukaryotes have not revealed a role for this protein in vivo [8].
  • A series of recent studies indicate that a core function of p120-catenin in mammalian cells is to regulate cadherin turnover by modulating the entry of cadherins into degradative endocytic pathways [9].
  • Collectively, the findings suggest exciting new roles for p120-catenin at the interface between cadherins and membrane trafficking machinery, and imply novel mechanisms by which p120-catenin may regulate cell adhesion and migration in the context of development and cancer [9].
  • As Kaiso associates with p120 catenin, Kaiso may link events at the cell surface with DNA methylation-dependent gene silencing [10].
  • A cloned subline of the human monocytic leukemia cell line, THP-1, was induced to produce high levels of cytotoxic activity following an 18-hour phorbol myristate acetate (CAS: 16561-29-8) stimulation in vitro [11].

Chemical compound and disease context of CTNND1


Biological context of CTNND1


Anatomical context of CTNND1


Associations of CTNND1 with chemical compounds


Physical interactions of CTNND1


Enzymatic interactions of CTNND1


Regulatory relationships of CTNND1


Other interactions of CTNND1

  • A core function for p120-catenin in cadherin turnover [30].
  • Both type I and type II cadherins are composed of five extracellular repeat domains with conserved calcium-binding motifs, a single pass transmembrane domain, and a highly conserved cytoplasmic domain that interacts with beta-catenin and p120 catenin [35].
  • More recently, attention has been directed towards p120-catenin, which in conjunction with the p120-catenin sub-family members ARVCF- and delta-catenins, are the subjects of this review [36].
  • During 3T3L1 adipogenesis there is a marked reduction in beta-catenin and N-cadherin expression with a relatively small decrease in p120 catenin protein levels [25].
  • Although originally identified as a Src substrate, p120-catenin (p120) is now known to regulate cell-cell adhesion through its interaction with the cytoplasmic tail of classical and type II cadherins [37].

Analytical, diagnostic and therapeutic context of CTNND1


  1. p120-catenin expression in human colorectal cancer. Skoudy, A., Gomez, S., Fabre, M., Garcia de Herreros, A. Int. J. Cancer (1996) [Pubmed]
  2. Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells. Ohno, H., Uemura, K., Shintani-Ishida, K., Nakamura, M., Inomata, M., Yoshida, K. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  3. Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival. Nakopoulou, L., Gakiopoulou-Givalou, H., Karayiannakis, A.J., Giannopoulou, I., Keramopoulos, A., Davaris, P., Pignatelli, M. Histopathology (2002) [Pubmed]
  4. Inducible expression of p120Cas1B isoform corroborates the role for p120-catenin as a positive regulator of E-cadherin function in intestinal cancer cells. Roura, S., Domínguez, D. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. Glomerular crescents predominantly express cadherin-catenin complex in pauci-immune-type crescentic glomerulonephritis. Usui, J., Kanemoto, K., Tomari, S., Shu, Y., Yoh, K., Mase, K., Hirayama, A., Hirayama, K., Yamagata, K., Nagase, S., Kobayashi, M., Nitta, K., Horita, S., Koyama, A., Nagata, M. Histopathology (2003) [Pubmed]
  6. p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Macpherson, I.R., Hooper, S., Serrels, A., McGarry, L., Ozanne, B.W., Harrington, K., Frame, M.C., Sahai, E., Brunton, V.G. Oncogene (2007) [Pubmed]
  7. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease. Yanagisawa, M., Huveldt, D., Kreinest, P., Lohse, C.M., Cheville, J.C., Parker, A.S., Copland, J.A., Anastasiadis, P.Z. J. Biol. Chem. (2008) [Pubmed]
  8. p120-catenin mediates inflammatory responses in the skin. Perez-Moreno, M., Davis, M.A., Wong, E., Pasolli, H.A., Reynolds, A.B., Fuchs, E. Cell (2006) [Pubmed]
  9. Protecting your tail: regulation of cadherin degradation by p120-catenin. Kowalczyk, A.P., Reynolds, A.B. Curr. Opin. Cell Biol. (2004) [Pubmed]
  10. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Prokhortchouk, A., Hendrich, B., Jørgensen, H., Ruzov, A., Wilm, M., Georgiev, G., Bird, A., Prokhortchouk, E. Genes Dev. (2001) [Pubmed]
  11. Isolation and initial characterization of tumoricidal monokine(s) from the human monocytic leukemia cell line THP-1. Armstrong, C.A., Klostergaard, J., Granger, G.A. J. Natl. Cancer Inst. (1985) [Pubmed]
  12. Safety evaluation of alpha-lipoic acid (ALA). Cremer, D.R., Rabeler, R., Roberts, A., Lynch, B. Regul. Toxicol. Pharmacol. (2006) [Pubmed]
  13. Phase III long-term study and comparative clinical study of nipradilol ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension. Kanno, M., Araie, M., Masuda, K., Takase, M., Kitazawa, Y., Shiose, Y., Azuma, I., Ogawa, N., Ohdo, S. Arzneimittel-Forschung (2006) [Pubmed]
  14. Pharmacodynamic study of low molecular weight dermatan sulphate (Desmin) after a single subcutaneous administration in patients with renal insufficiency. Saivin, S., Boneu, B., Ducret, F., Pourrat, J., Palazzini, E., Zamboni, W., Duchêne, P., Houin, G. Arzneimittel-Forschung. (2000) [Pubmed]
  15. Effect of the calcium antagonist benidipine hydrochloride on 24-h ambulatory blood pressure in patients with mild to moderate hypertension in a double-blind study against placebo. Nakajima, O., Akioka, H., Miyazaki, M. Arzneimittel-Forschung. (2000) [Pubmed]
  16. Evaluation of anti-inflammatory and analgesic activity of a new class of biphenyl analogs in animal models of inflammation. Rathi, B.S., Wagh, N.K., Bodhankar, S.L., Kulkarni, V.M. Arzneimittel-Forschung. (2006) [Pubmed]
  17. Regulation of the rapsyn promoter by kaiso and delta-catenin. Rodova, M., Kelly, K.F., VanSaun, M., Daniel, J.M., Werle, M.J. Mol. Cell. Biol. (2004) [Pubmed]
  18. Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. Kondapalli, J., Flozak, A.S., Albuquerque, M.L. J. Biol. Chem. (2004) [Pubmed]
  19. p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin. Xiao, K., Garner, J., Buckley, K.M., Vincent, P.A., Chiasson, C.M., Dejana, E., Faundez, V., Kowalczyk, A.P. Mol. Biol. Cell (2005) [Pubmed]
  20. An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation. Ferber, A., Yaen, C., Sarmiento, E., Martinez, J. Exp. Cell Res. (2002) [Pubmed]
  21. Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. Xiao, K., Allison, D.F., Buckley, K.M., Kottke, M.D., Vincent, P.A., Faundez, V., Kowalczyk, A.P. J. Cell Biol. (2003) [Pubmed]
  22. TNF-{alpha} increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. Angelini, D.J., Hyun, S.W., Grigoryev, D.N., Garg, P., Gong, P., Singh, I.S., Passaniti, A., Hasday, J.D., Goldblum, S.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  23. p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. Chen, X., Kojima, S., Borisy, G.G., Green, K.J. J. Cell Biol. (2003) [Pubmed]
  24. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. Noren, N.K., Liu, B.P., Burridge, K., Kreft, B. J. Cell Biol. (2000) [Pubmed]
  25. Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking. Hou, J.C., Shigematsu, S., Crawford, H.C., Anastasiadis, P.Z., Pessin, J.E. J. Biol. Chem. (2006) [Pubmed]
  26. p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Piedra, J., Miravet, S., Castaño, J., Pálmer, H.G., Heisterkamp, N., García de Herreros, A., Duñach, M. Mol. Cell. Biol. (2003) [Pubmed]
  27. Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. Coussen, F., Normand, E., Marchal, C., Costet, P., Choquet, D., Lambert, M., Mège, R.M., Mulle, C. J. Neurosci. (2002) [Pubmed]
  28. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Lehtonen, S., Lehtonen, E., Kudlicka, K., Holthöfer, H., Farquhar, M.G. Am. J. Pathol. (2004) [Pubmed]
  29. Effective dephosphorylation of Src substrates by SHP-1. Frank, C., Burkhardt, C., Imhof, D., Ringel, J., Zschörnig, O., Wieligmann, K., Zacharias, M., Böhmer, F.D. J. Biol. Chem. (2004) [Pubmed]
  30. A core function for p120-catenin in cadherin turnover. Davis, M.A., Ireton, R.C., Reynolds, A.B. J. Cell Biol. (2003) [Pubmed]
  31. Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1. Rubio, M.E., Curcio, C., Chauvet, N., Brusés, J.L. Mol. Cell. Neurosci. (2005) [Pubmed]
  32. The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin. Keilhack, H., Hellman, U., van Hengel, J., van Roy, F., Godovac-Zimmermann, J., Böhmer, F.D. J. Biol. Chem. (2000) [Pubmed]
  33. Identification of Src phosphorylation sites in the catenin p120ctn. Mariner, D.J., Anastasiadis, P., Keilhack, H., Böhmer, F.D., Wang, J., Reynolds, A.B. J. Biol. Chem. (2001) [Pubmed]
  34. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Hosking, C.R., Ulloa, F., Hogan, C., Ferber, E.C., Figueroa, A., Gevaert, K., Birchmeier, W., Briscoe, J., Fujita, Y. Mol. Biol. Cell (2007) [Pubmed]
  35. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. Katafiasz, B.J., Nieman, M.T., Wheelock, M.J., Johnson, K.R. J. Biol. Chem. (2003) [Pubmed]
  36. Developmental functions of the P120-catenin sub-family. McCrea, P.D., Park, J.I. Biochim. Biophys. Acta (2007) [Pubmed]
  37. Emerging roles for p120-catenin in cell adhesion and cancer. Reynolds, A.B., Roczniak-Ferguson, A. Oncogene (2004) [Pubmed]
  38. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Keirsebilck, A., Bonné, S., Staes, K., van Hengel, J., Nollet, F., Reynolds, A., van Roy, F. Genomics (1998) [Pubmed]
  39. Fibrinogen and antithrombin III blood levels fluctuations during isoniazid or isoniazid plus rifampicin administration. Farmakis, M., Travlou, O., Aroni, S., Fertakis, A. Arzneimittel-Forschung. (1992) [Pubmed]
  40. Preliminary radiological evaluation of the Vector Vision CT-free knee module for implantation of the LCS knee prosthesis. Malik, M.H., Wadia, F., Porter, M.L. Knee (2007) [Pubmed]
  41. Computer-assisted orbital surgery. Klimek, L., Wenzel, M., Mösges, R. Ophthalmic surgery. (1993) [Pubmed]
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