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MeSH Review

Genes, Retinoblastoma

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Disease relevance of Genes, Retinoblastoma


High impact information on Genes, Retinoblastoma

  • The retinoblastoma (RB) gene is one of the most extensively studied tumour-suppressor genes [5].
  • This 105 kd E1A-binding protein cross-reacts with two different antibodies against the retinoblastoma (RB) gene product [6].
  • A gene encoding a messenger RNA (mRNA) of 4.6 kilobases (kb), located in the proximity of esterase D, was identified as the retinoblastoma susceptibility (RB) gene on the basis of chromosomal location, homozygous deletion, and tumor-specific alterations in expression [7].
  • Our results are consistent with the model that autocrine production of TGF-beta negatively regulates the cycling status of early hematopoietic progenitors through interaction with the Rb gene product [8].
  • The protein product of the retinoblastoma (RB) gene is thought to function in a pathway that restricts cell proliferation [9].

Chemical compound and disease context of Genes, Retinoblastoma


Biological context of Genes, Retinoblastoma


Anatomical context of Genes, Retinoblastoma


Associations of Genes, Retinoblastoma with chemical compounds


Gene context of Genes, Retinoblastoma

  • In both LS513 and LS1034, WAF1 induction correlated with reduced cyclin E-associated kinase activity in vitro and suppression of the retinoblastoma susceptibility gene (Rb) protein phosphorylation in vivo [25].
  • Notably, alterations of one of the CDKIs, p53 and Rb genes appear to obviate the need for inactivation of other genes in the same pathway [26].
  • Our previous and these results suggested that the expression level of MDM2 protein is independent of the status of the p14ARF, p53, Rb genes [27].
  • These results demonstrate that OxLDL or its lipid peroxidation products, by generation of an oxidative stress, enhances the expression of p21 and Rb genes, leading to an accumulation of the Hypo-P active form of the tumor suppressor Rb [28].
  • In full-term placenta c-myc expression was undetectable while Rb gene product and PCNA immunoreactivity declined markedly [29].

Analytical, diagnostic and therapeutic context of Genes, Retinoblastoma


  1. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Hinds, P.W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S.I., Weinberg, R.A. Cell (1992) [Pubmed]
  2. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Harbour, J.W., Lai, S.L., Whang-Peng, J., Gazdar, A.F., Minna, J.D., Kaye, F.J. Science (1988) [Pubmed]
  3. Altered expression of the retinoblastoma gene product: prognostic indicator in bladder cancer. Cordon-Cardo, C., Wartinger, D., Petrylak, D., Dalbagni, G., Fair, W.R., Fuks, Z., Reuter, V.E. J. Natl. Cancer Inst. (1992) [Pubmed]
  4. E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Wang, H.G., Draetta, G., Moran, E. Mol. Cell. Biol. (1991) [Pubmed]
  5. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach, J.T., Zhang, M., Niu, C.H., Thorgeirsson, S.S. Nat. Genet. (1998) [Pubmed]
  6. The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F. Bagchi, S., Weinmann, R., Raychaudhuri, P. Cell (1991) [Pubmed]
  7. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Lee, W.H., Bookstein, R., Hong, F., Young, L.J., Shew, J.Y., Lee, E.Y. Science (1987) [Pubmed]
  8. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides. Hatzfeld, J., Li, M.L., Brown, E.L., Sookdeo, H., Levesque, J.P., O'Toole, T., Gurney, C., Clark, S.C., Hatzfeld, A. J. Exp. Med. (1991) [Pubmed]
  9. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. Hu, Q.J., Dyson, N., Harlow, E. EMBO J. (1990) [Pubmed]
  10. Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells. Slack, R.S., Hamel, P.A., Bladon, T.S., Gill, R.M., McBurney, M.W. Oncogene (1993) [Pubmed]
  11. Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. Van Poznak, C., Seidman, A.D., Reidenberg, M.M., Moasser, M.M., Sklarin, N., Van Zee, K., Borgen, P., Gollub, M., Bacotti, D., Yao, T.J., Bloch, R., Ligueros, M., Sonenberg, M., Norton, L., Hudis, C. Breast Cancer Res. Treat. (2001) [Pubmed]
  12. Molecular mechanisms of resistance to antifolates, a review. Banerjee, D., Ercikan-Abali, E., Waltham, M., Schnieders, B., Hochhauser, D., Li, W.W., Fan, J., Gorlick, R., Goker, E., Bertino, J.R. Acta Biochim. Pol. (1995) [Pubmed]
  13. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. Macleod, K.F., Hu, Y., Jacks, T. EMBO J. (1996) [Pubmed]
  14. Cyclin D1 expression is regulated by the retinoblastoma protein. Müller, H., Lukas, J., Schneider, A., Warthoe, P., Bartek, J., Eilers, M., Strauss, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  15. Dinucleotide repeat polymorphism at the human PDGF RB gene. Yaraghi, Z., Kang, X., Ikeda, J.E., MacKenzie, A. Hum. Mol. Genet. (1994) [Pubmed]
  16. K-ras codon 12 mutation determines the polypoid growth of colorectral cancer. Chiang, J.M., Chou, Y.H., Chou, T.B. Cancer Res. (1998) [Pubmed]
  17. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. te Riele, H., Maandag, E.R., Berns, A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  18. Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts. Herrera, R.E., Chen, F., Weinberg, R.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  19. Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. Pérez-Simón, J.A., García-Sanz, R., Tabernero, M.D., Almeida, J., González, M., Fernández-Calvo, J., Moro, M.J., Hernández, J.M., San Miguel, J.F., Orfão, A. Blood (1998) [Pubmed]
  20. Rb functions to inhibit apoptosis during myocyte differentiation. Wang, J., Guo, K., Wills, K.N., Walsh, K. Cancer Res. (1997) [Pubmed]
  21. Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines. Deng, W., Tsao, S.W., Guan, X.Y., Lucas, J.N., Si, H.X., Leung, C.S., Mak, P., Wang, L.D., Cheung, A.L. Oncogene (2004) [Pubmed]
  22. Analysis of the Rb gene and cyclin-dependent kinase 4 inhibitor genes (p16INK4 and p15INK4B) in human ovarian carcinoma cell lines. Yaginuma, Y., Hayashi, H., Kawai, K., Kurakane, T., Saitoh, Y., Kitamura, S., Sengoku, K., Ishikawa, M. Exp. Cell Res. (1997) [Pubmed]
  23. Retinoblastoma gene mutations in chemically induced liver tumor samples of Japanese medaka (Oryzias latipes). Rotchell, J.M., Ulnal, E., Van Beneden, R.J., Ostrander, G.K. Mar. Biotechnol. (2001) [Pubmed]
  24. Estrogenic effects on prostatic differentiation and carcinogenesis. Cunha, G.R., Wang, Y.Z., Hayward, S.W., Risbridger, G.P. Reprod. Fertil. Dev. (2001) [Pubmed]
  25. Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. Li, C.Y., Suardet, L., Little, J.B. J. Biol. Chem. (1995) [Pubmed]
  26. Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL). Hatta, Y., Koeffler, H.P. Leukemia (2002) [Pubmed]
  27. Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms. Sugimoto, K.J., Kawamata, N., Sakajiri, S., Oshimi, K. Jpn. J. Cancer Res. (2002) [Pubmed]
  28. Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21(waf1) and the tumor suppressor Rb. Mazière, C., Marcheux, V., Louandre, C., Mazière, J.C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  29. C-myc and tumour suppressor gene product expression in developing and term human trophoblast. Roncalli, M., Bulfamante, G., Viale, G., Springall, D.R., Alfano, R., Comi, A., Maggioni, M., Polak, J.M., Coggi, G. Placenta (1994) [Pubmed]
  30. Molecular characterization of CD30+ anaplastic large-cell lymphoma: high frequency of c-myc proto-oncogene activation. Inghirami, G., Macri, L., Cesarman, E., Chadburn, A., Zhong, J., Knowles, D.M. Blood (1994) [Pubmed]
  31. Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group. Reissmann, P.T., Koga, H., Takahashi, R., Figlin, R.A., Holmes, E.C., Piantadosi, S., Cordon-Cardo, C., Slamon, D.J. Oncogene (1993) [Pubmed]
  32. The retinoblastoma gene: a prototypic and multifunctional tumor suppressor. Zheng, L., Lee, W.H. Exp. Cell Res. (2001) [Pubmed]
  33. The phosphorylation of retinoblastoma gene product in human myeloid leukemia cells during the cell cycle. Zhang, W., Hittelman, W., Van, N., Andreeff, M., Deisseroth, A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  34. The RB gene locates on chromosome 15 at band 15q13 in the Syrian hamster. Satoh, H., Ebert, R., Wiseman, R.W., Barrett, J.C. Cytogenet. Cell Genet. (1994) [Pubmed]
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