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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Genes, Retinoblastoma

 
 
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Disease relevance of Genes, Retinoblastoma

 

High impact information on Genes, Retinoblastoma

  • The retinoblastoma (RB) gene is one of the most extensively studied tumour-suppressor genes [5].
  • This 105 kd E1A-binding protein cross-reacts with two different antibodies against the retinoblastoma (RB) gene product [6].
  • A gene encoding a messenger RNA (mRNA) of 4.6 kilobases (kb), located in the proximity of esterase D, was identified as the retinoblastoma susceptibility (RB) gene on the basis of chromosomal location, homozygous deletion, and tumor-specific alterations in expression [7].
  • Our results are consistent with the model that autocrine production of TGF-beta negatively regulates the cycling status of early hematopoietic progenitors through interaction with the Rb gene product [8].
  • The protein product of the retinoblastoma (RB) gene is thought to function in a pathway that restricts cell proliferation [9].
 

Chemical compound and disease context of Genes, Retinoblastoma

 

Biological context of Genes, Retinoblastoma

 

Anatomical context of Genes, Retinoblastoma

 

Associations of Genes, Retinoblastoma with chemical compounds

 

Gene context of Genes, Retinoblastoma

  • In both LS513 and LS1034, WAF1 induction correlated with reduced cyclin E-associated kinase activity in vitro and suppression of the retinoblastoma susceptibility gene (Rb) protein phosphorylation in vivo [25].
  • Notably, alterations of one of the CDKIs, p53 and Rb genes appear to obviate the need for inactivation of other genes in the same pathway [26].
  • Our previous and these results suggested that the expression level of MDM2 protein is independent of the status of the p14ARF, p53, Rb genes [27].
  • These results demonstrate that OxLDL or its lipid peroxidation products, by generation of an oxidative stress, enhances the expression of p21 and Rb genes, leading to an accumulation of the Hypo-P active form of the tumor suppressor Rb [28].
  • In full-term placenta c-myc expression was undetectable while Rb gene product and PCNA immunoreactivity declined markedly [29].
 

Analytical, diagnostic and therapeutic context of Genes, Retinoblastoma

References

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  2. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Harbour, J.W., Lai, S.L., Whang-Peng, J., Gazdar, A.F., Minna, J.D., Kaye, F.J. Science (1988) [Pubmed]
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  5. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach, J.T., Zhang, M., Niu, C.H., Thorgeirsson, S.S. Nat. Genet. (1998) [Pubmed]
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  19. Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. Pérez-Simón, J.A., García-Sanz, R., Tabernero, M.D., Almeida, J., González, M., Fernández-Calvo, J., Moro, M.J., Hernández, J.M., San Miguel, J.F., Orfão, A. Blood (1998) [Pubmed]
  20. Rb functions to inhibit apoptosis during myocyte differentiation. Wang, J., Guo, K., Wills, K.N., Walsh, K. Cancer Res. (1997) [Pubmed]
  21. Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines. Deng, W., Tsao, S.W., Guan, X.Y., Lucas, J.N., Si, H.X., Leung, C.S., Mak, P., Wang, L.D., Cheung, A.L. Oncogene (2004) [Pubmed]
  22. Analysis of the Rb gene and cyclin-dependent kinase 4 inhibitor genes (p16INK4 and p15INK4B) in human ovarian carcinoma cell lines. Yaginuma, Y., Hayashi, H., Kawai, K., Kurakane, T., Saitoh, Y., Kitamura, S., Sengoku, K., Ishikawa, M. Exp. Cell Res. (1997) [Pubmed]
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  27. Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms. Sugimoto, K.J., Kawamata, N., Sakajiri, S., Oshimi, K. Jpn. J. Cancer Res. (2002) [Pubmed]
  28. Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21(waf1) and the tumor suppressor Rb. Mazière, C., Marcheux, V., Louandre, C., Mazière, J.C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  29. C-myc and tumour suppressor gene product expression in developing and term human trophoblast. Roncalli, M., Bulfamante, G., Viale, G., Springall, D.R., Alfano, R., Comi, A., Maggioni, M., Polak, J.M., Coggi, G. Placenta (1994) [Pubmed]
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