Gene Review:
TOPORS - topoisomerase I binding, arginine/serine...
Homo sapiens
Synonyms:
E3 ubiquitin-protein ligase Topors, LUN, P53BP3, RP31, SUMO1-protein E3 ligase Topors, ...
- The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor. Saleem, A., Dutta, J., Malegaonkar, D., Rasheed, F., Rasheed, Z., Rajendra, R., Marshall, H., Luo, M., Li, H., Rubin, E.H. Oncogene (2004)
- Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence. Chu, D., Kakazu, N., Gorrin-Rivas, M.J., Lu, H.P., Kawata, M., Abe, T., Ueda, K., Adachi, Y. J. Biol. Chem. (2001)
- Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. Rajendra, R., Malegaonkar, D., Pungaliya, P., Marshall, H., Rasheed, Z., Brownell, J., Liu, L.F., Lutzker, S., Saleem, A., Rubin, E.H. J. Biol. Chem. (2004)
- Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression. Weger, S., Hammer, E., Heilbronn, R. J. Gen. Virol. (2002)
- Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. Haluska, P., Saleem, A., Rasheed, Z., Ahmed, F., Su, E.W., Liu, L.F., Rubin, E.H. Nucleic Acids Res. (1999)
- Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo. Weger, S., Hammer, E., Heilbronn, R. FEBS Lett. (2005)
- The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies. Rasheed, Z.A., Saleem, A., Ravee, Y., Pandolfi, P.P., Rubin, E.H. Exp. Cell Res. (2002)
- Quantifying deficits in the 3D force capabilities of a digit caused by selective paralysis: application to the thumb with simulated low ulnar nerve palsy. Kuxhaus, L., Roach, S.S., Valero-Cuevas, F.J. Journal of biomechanics. (2005)
- The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation. Weger, S., Hammer, E., Engstler, M. Exp. Cell Res. (2003)
- Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer. Oyanagi, H., Takenaka, K., Ishikawa, S., Kawano, Y., Adachi, Y., Ueda, K., Wada, H., Tanaka, F. Lung Cancer (2004)
- Patterns of failure in combined chemotherapy and radiotherapy for limited small cell lung cancer: Southeastern Cancer Study Group experience. Birch, R., Omura, G.A., Greco, F.A., Perez, C.A. NCI monographs : a publication of the National Cancer Institute. (1988)