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Gene Review

GABARAPL1  -  GABA(A) receptor-associated protein like 1

Homo sapiens

Synonyms: APG8-LIKE, APG8L, ATG8, ATG8B, ATG8L, ...
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Disease relevance of GABARAPL1


High impact information on GABARAPL1

  • This pathway was of functional relevance, because targeting of the influenza matrix protein 1 to autophagosomes via fusion to the autophagosome-associated protein Atg8/LC3 led to strongly enhanced MHC class II presentation to CD4(+) T cell clones [2].
  • Inhibition of autophagy by chemical compounds or knocking down the expression of key autophagy proteins such as ATG7, ATG8, and receptor interacting protein (RIP) blocks ROS accumulation and cell death [3].
  • When expressed in Chinese hamster ovary (CHO) cells, GEC1 co-immunoprecipitated with FLAG-hKOR [4].
  • The interaction with NSF may contribute to GEC1 effects [4].
  • Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16 [5].

Biological context of GABARAPL1


Anatomical context of GABARAPL1


Associations of GABARAPL1 with chemical compounds

  • Analysis of the guinea-pig estrogen-regulated gec1/GABARAPL1 gene promoter and identification of a functional ERE in the first exon [10].
  • Each purified mutant Atg8 homolog with an exposed C-terminal Gly formed an E1-substrate intermediate with hAtg7 via a thioester bond in an ATP-dependent manner and formed an E2-substrate intermediate with hAtg3 via a thioester bond dependent on ATP and hAtg7 [5].
  • The E2 action on gec1 gene required the presence of cycloheximide [13].
  • Here, we demonstrate that MPP(+) elicited increased autophagy in SH-SY5Y cells, as assessed by electron microscopy, immunofluorescence for the autophagy protein LC3/Atg8, LC3 electrophoretic mobility shift, mitochondrial degradation, and monodansylcadaverine staining for late AVs/autolysosomes [14].
  • Atg4 is a novel cysteine protease that processes and deconjugates Atg8 [8].

Physical interactions of GABARAPL1

  • Coupled with our previous observation that GEC1 interacts with N-ethylmaleimide-sensitive factor, these findings strongly suggest that GEC1 functions in intracellular trafficking in the biosynthesis pathway and perhaps also the endocytic pathway [12].

Other interactions of GABARAPL1


Analytical, diagnostic and therapeutic context of GABARAPL1


  1. Differential effects of thrombin and hypoxia on endometrial stromal and glandular epithelial cell vascular endothelial growth factor expression. Lockwood, C.J., Krikun, G., Koo, A.B., Kadner, S., Schatz, F. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  2. Antigen-Loading Compartments for Major Histocompatibility Complex Class II Molecules Continuously Receive Input from Autophagosomes. Schmid, D., Pypaert, M., Münz, C. Immunity (2007) [Pubmed]
  3. Autophagic programmed cell death by selective catalase degradation. Yu, L., Wan, F., Dutta, S., Welsh, S., Liu, Z., Freundt, E., Baehrecke, E.H., Lenardo, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. Chen, C., Li, J.G., Chen, Y., Huang, P., Wang, Y., Liu-Chen, L.Y. J. Biol. Chem. (2006) [Pubmed]
  5. Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. Sou, Y.S., Tanida, I., Komatsu, M., Ueno, T., Kominami, E. J. Biol. Chem. (2006) [Pubmed]
  6. A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP. Vernier-Magnin, S., Muller, S., Sallot, M., Radom, J., Musard, J.F., Adami, P., Dulieu, P., Rémy-Martin, J.P., Jouvenot, M., Fraichard, A. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Specific distribution of gabarap, gec1/gabarap Like 1, gate16/gabarap Like 2, lc3 messenger RNAs in rat brain areas by quantitative real-time PCR. Mansuy-Schlick, V., Tolle, F., Delage-Mourroux, R., Fraichard, A., Risold, P.Y., Jouvenot, M. Brain Res. (2006) [Pubmed]
  8. Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. Sugawara, K., Suzuki, N.N., Fujioka, Y., Mizushima, N., Ohsumi, Y., Inagaki, F. J. Biol. Chem. (2005) [Pubmed]
  9. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. Xin, Y., Yu, L., Chen, Z., Zheng, L., Fu, Q., Jiang, J., Zhang, P., Gong, R., Zhao, S. Genomics (2001) [Pubmed]
  10. Analysis of the guinea-pig estrogen-regulated gec1/GABARAPL1 gene promoter and identification of a functional ERE in the first exon. Vernier-Magnin, S., Nemos, C., Mansuy, V., Tolle, F., Guichard, L., Delage-Mourroux, R., Jouvenot, M., Fraichard, A. Biochim. Biophys. Acta (2005) [Pubmed]
  11. The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. Kumanomidou, T., Mizushima, T., Komatsu, M., Suzuki, A., Tanida, I., Sou, Y.S., Ueno, T., Kominami, E., Tanaka, K., Yamane, T. J. Mol. Biol. (2006) [Pubmed]
  12. Distribution and ultrastructural localization of GEC1 in the rat CNS. Wang, Y., Dun, S.L., Huang, P., Chen, C., Chen, Y., Unterwald, E.M., Dun, N.J., Van Bockstaele, E.J., Liu-Chen, L.Y. Neuroscience (2006) [Pubmed]
  13. Identification and characterization of an early estrogen-regulated RNA in cultured guinea-pig endometrial cells. Pellerin, I., Vuillermoz, C., Jouvenot, M., Ordener, C., Royez, M., Adessi, G.L. Mol. Cell. Endocrinol. (1993) [Pubmed]
  14. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Zhu, J.H., Horbinski, C., Guo, F., Watkins, S., Uchiyama, Y., Chu, C.T. Am. J. Pathol. (2007) [Pubmed]
  15. Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: predominance of gec1/GABARAPL1 in the central nervous system. Nemos, C., Mansuy, V., Vernier-Magnin, S., Fraichard, A., Jouvenot, M., Delage-Mourroux, R. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  16. Production and secretion of complement component 3 by endometriotic tissue. Isaacson, K.B., Coutifaris, C., Garcia, C.R., Lyttle, C.R. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  17. Secretory component in human mammary carcinoma. Harris, J.P., Caleb, M.H., South, M.A. Cancer Res. (1975) [Pubmed]
  18. Study of secretory component in patients with metastatic breast cancer. Puleo, E.A., Haagensen, D.E., Dawson, J.R., Gall, S.A. Am. J. Obstet. Gynecol. (1979) [Pubmed]
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