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Gene Review

APOBEC2  -  apolipoprotein B mRNA editing enzyme,...

Homo sapiens

Synonyms: ARCD1, ARP1
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Disease relevance of APOBEC2


High impact information on APOBEC2

  • This element binds to two members of the steroid hormone receptor superfamily of transcription factors produced in enterocytes and Caco-2 cells: hepatic nuclear factor-4 (HNF-4) and apolipoprotein regulatory protein-1 (ARP-1) [3].
  • Supplementation of the extracts with purified polypeptides representing fusions between the ARP-1 N- or C-terminal domains and the yeast activator GAL4 DNA binding domain also stimulated transcription from a basal promoter linked to multiple GAL4 DNA binding sites [1].
  • We conclude that ARP-1 possesses intrinsic transcription activation potential which is modulated, at least in part, by the intracellular balance of other nuclear receptors that also bind to its cognate DNA binding site [1].
  • In in vitro transcription assays, Hela cell nuclear extracts which contain ARP-1 had no effect on transcription from a basal promoter linked to multiple copies of site A [1].
  • We conclude that AID and APOBEC2 are likely to be the ancestral members of the AID/APOBEC family (going back to the beginning of vertebrate speciation) with both APOBEC1 and APOBEC3 being mammal-specific derivatives of AID and a complex set of domain shuffling underpinning the expansion and evolution of the primate APOBEC3s [4].

Biological context of APOBEC2


Anatomical context of APOBEC2


Regulatory relationships of APOBEC2


Other interactions of APOBEC2


Analytical, diagnostic and therapeutic context of APOBEC2

  • Gene-targeting experiments reveal that both APOBEC2 (despite being an ancestral member of the family with no obvious redundancy in muscle) and APOBEC3 (despite its proposed role in restricting endogenous retrotransposition) are inessential for mouse development, survival, or fertility [10].
  • Co-immunoprecipitation assays using ARP-1-selective antibodies revealed specific physical interactions between ARP-1 and the basal transcription factor TFIIB [1].
  • PURPOSE: To establish a method for the recording of multifocal electroretinograms (MF-ERGs) in animals under fundus control using a scanning-laser ophthalmoscope (SLO) and to analyze the spatial distribution of disease in a strain of Abyssinian cats with a recessively inherited rod-cone degeneration (ARCD) [11].


  1. Transcriptional activation by the orphan nuclear receptor ARP-1. Malik, S., Karathanasis, S. Nucleic Acids Res. (1995) [Pubmed]
  2. PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Wang, W., Hayashi, J., Serrero, G. Clin. Cancer Res. (2006) [Pubmed]
  3. Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice. Rottman, J.N., Gordon, J.I. J. Biol. Chem. (1993) [Pubmed]
  4. Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Conticello, S.G., Thomas, C.J., Petersen-Mahrt, S.K., Neuberger, M.S. Mol. Biol. Evol. (2005) [Pubmed]
  5. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Jarmuz, A., Chester, A., Bayliss, J., Gisbourne, J., Dunham, I., Scott, J., Navaratnam, N. Genomics (2002) [Pubmed]
  6. Expression of APOBEC2 is transcriptionally regulated by NF-kappaB in human hepatocytes. Matsumoto, T., Marusawa, H., Endo, Y., Ueda, Y., Matsumoto, Y., Chiba, T. FEBS Lett. (2006) [Pubmed]
  7. ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. Anant, S., Mukhopadhyay, D., Sankaranand, V., Kennedy, S., Henderson, J.O., Davidson, N.O. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  8. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. Liao, W., Hong, S.H., Chan, B.H., Rudolph, F.B., Clark, S.C., Chan, L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  9. APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. Rogozin, I.B., Basu, M.K., Jordan, I.K., Pavlov, Y.I., Koonin, E.V. Cell Cycle (2005) [Pubmed]
  10. Mice deficient in APOBEC2 and APOBEC3. Mikl, M.C., Watt, I.N., Lu, M., Reik, W., Davies, S.L., Neuberger, M.S., Rada, C. Mol. Cell. Biol. (2005) [Pubmed]
  11. Functional assessment of the regional distribution of disease in a cat model of hereditary retinal degeneration. Seeliger, M.W., Narfström, K. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
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