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Gene Review

Emv1  -  endogenous ecotropic MuLV 1

Mus musculus

Synonyms: C3v, Cv-1, Emv-1, Inc-1, Rjv-2
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Disease relevance of Emv1


High impact information on Emv1


Biological context of Emv1


Anatomical context of Emv1


Associations of Emv1 with chemical compounds

  • The characteristics of this immune response, however, were identical in control and irradiated mice in terms of peak titers, specificity for endogenous ecotropic MuLV, and reactivity against the ecotropic viruses' glycoprotein (gp71) [4].

Other interactions of Emv1

  • Mice related to BALB/c in origin carry a locus termed Inc-1, whereas mice related to B6 carry an Inb-1 locus [8].
  • Finally, comparison of the new sequences of Emv-3 with those of the Akv virus (also designated AKR-623 and Emv-11) and Emv-1 shows that this endogenous virus locus is very closely related to the other Emv loci at the nucleotide sequence level [16].
  • The most proximal of the conserved markers on the mouse map, D4S43h, showed no recombination with Emv-1, an endogenous ecotropic virus, in 84 outcross progeny and 19 recombinant inbred strains [17].
  • Hx, a dominant mutation that causes deformities in limb development, maps approximately 2 cM proximal to Emv-1 [17].
  • Some recombinant ecotropic viruses contained sequences in the p15E-U3 region that were not derived from Emv-1 and Emv-3 but were found in recombinant polytropic HRS/J viruses [18].


  1. High frequency germline acquisition of ecotropic MuLV proviruses in SWR/J-RF/J hybrid mice. Jenkins, N.A., Copeland, N.G. Cell (1985) [Pubmed]
  2. Pathogenic determinants in the U3 region of recombinant murine leukemia viruses isolated from CWD and HRS/J mice. Lawrenz-Smith, S.C., Massey, A.C., Innes, D.J., Thomas, C.Y. J. Virol. (1994) [Pubmed]
  3. Phenotypic changes and loss of melanoma-specific endogenous C-type retroviruses in BL6 melanoma cells transfected with the H-2Kb gene. Muller, J., Khan, A.S., Li, M., Rao, V., Hearing, V.J., Gorelik, E. Melanoma Res. (1996) [Pubmed]
  4. Radiation leukemia in C57BL/6 mice. I. Lack of serological evidence for the role of endogenous ecotropic viruses in pathogenesis. Ihle, J.N., McEwan, R., Bengali, K. J. Exp. Med. (1976) [Pubmed]
  5. Loss of pathogenicity of spleen focus-forming virus after pseudotyping with Akv. Jones, K.S., Ruscetti, S., Lilly, F. J. Virol. (1988) [Pubmed]
  6. Genetic interactions in induction of endogenous murine leukemia virus from low leukemic mice. McCubrey, J., Risser, R. Cell (1982) [Pubmed]
  7. Pathogenesis of arteritis of SL/Ni mice. Possible lytic effect of anti-gp70 antibodies on vascular smooth muscle cells. Miyazawa, M., Nose, M., Kawashima, M., Kyogoku, M. J. Exp. Med. (1987) [Pubmed]
  8. Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice. McCubrey, J., Risser, R. J. Exp. Med. (1982) [Pubmed]
  9. Structure and expression of endogenous ecotropic murine leukemia viruses in RF/J mice. McCubrey, J., Horowitz, J.M., Risser, R. J. Exp. Med. (1982) [Pubmed]
  10. The E47 transcription factor binds to the enhancer sequences of recombinant murine leukemia viruses and influences enhancer function. Lawrenz-Smith, S.C., Thomas, C.Y. J. Virol. (1995) [Pubmed]
  11. Structure of endogenous murine leukemia virus DNA in mouse genomes. Chattopadhyay, S.K., Lander, M.R., Rands, E., Lowy, D.R. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  12. Kinetics of expression of infectious ecotropic, xenotropic, and mink cell focus-forming murine leukemia virus after 5-iododeoxyuridine induction of cells from high- and low-leukemia mouse strains. Rapp, U.R. J. Virol. (1983) [Pubmed]
  13. Characterization of a novel murine retrovirus mixture that facilitates hematopoiesis. Hook, L.M., Jude, B.A., Ter-Grigorov, V.S., Hartley, J.W., Morse, H.C., Trainin, Z., Toder, V., Chervonsky, A.V., Golovkina, T.V. J. Virol. (2002) [Pubmed]
  14. Macrocytic-megaloblastic anemia in male NIH Swiss mice following repeated exposure to 1,3-butadiene. Irons, R.D., Smith, C.N., Stillman, W.S., Shah, R.S., Steinhagen, W.H., Leiderman, L.J. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  15. Endogenous ecotropic murine leukemia viral (MuLV) envelope protein as a new autoantigen reactive with non-obese diabetic mice sera. Choi, S.E., Kim, K.S., Kim, K.H., Choi, U.Y., Kim, H.M., Yoon, J.W., Kang, Y. J. Autoimmun. (2000) [Pubmed]
  16. A replication-competent, endogenous retrovirus from an aged DBA/2 mouse contains the complete env from Emv-3 and a novel gag partially related to AKT-8. Bartman, T., Murasko, D.M., Blank, K.J. J. Virol. (1995) [Pubmed]
  17. Synteny on mouse chromosome 5 of homologs for human DNA loci linked to the Huntington disease gene. Cheng, S.V., Martin, G.R., Nadeau, J.H., Haines, J.L., Bucan, M., Kozak, C.A., MacDonald, M.E., Lockyer, J.L., Ledley, F.D., Woo, S.L. Genomics (1989) [Pubmed]
  18. Role of recombinant ecotropic and polytropic viruses in the development of spontaneous thymic lymphomas in HRS/J mice. Thomas, C.Y., Khiroya, R., Schwartz, R.S., Coffin, J.M. J. Virol. (1984) [Pubmed]
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