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Gene Review

Igh-C  -  immunoglobulin heavy chain constant region

Mus musculus

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Disease relevance of Igh-C


Psychiatry related information on Igh-C

  • These results have implications both for network interactions in the immune response and for the genetic basis of Igh-C linked Id expression [5].

High impact information on Igh-C


Biological context of Igh-C


Anatomical context of Igh-C

  • The data are discussed in terms to T cell enhancement of IgG2a Ab synthesis being mediated through T cell enhancement of the Igh-C gene switching mechanism within TNP-Ficoll-responsive B cell clones [16].
  • Our results have suggested that IgG anti-DNA responses occurring as a result of polyclonal B cell activation during the course of malaria infection markedly differs quantitatively and clonotypically among murine strains and appear to be controlled at least in part by the Igh-C gene or gene(s) closely linked to it [17].
  • Chimeric mice are constructed by reconstituting lethally irradiated mice with peritoneal cells (PerC) and bone marrow cells from congenic pairs of mice differing in Igh-C allotype [18].
  • Two kinds of circular DNA were identified in the lymph nodes as excision products of switch recombination of immunoglobulin heavy-chain constant region (CH) genes [19].
  • The positions of nuclear matrix anchorage regions (MARs) have been mapped within the 200 kb mouse immunoglobulin heavy chain constant region locus, thereby allowing an estimate of the size of DNA domains within a segment of the genome [20].

Associations of Igh-C with chemical compounds

  • T15 idiotype expression in the murine response to phosphorylcholine is actively regulated by genes linked to the Igh-C locus [21].

Physical interactions of Igh-C


Regulatory relationships of Igh-C

  • Furthermore, they suggest that the 11-5 IdX markers identified are shared by alloantibodies of the BALB/c (Igh1a) and A.TH (Igh1e) mouse strains and may be expressed independently of Igh-C allotype markers [25].

Other interactions of Igh-C

  • On the basis of these results the Igh-Ox marker is tentatively placed between Igh-C and the rest of the Igh-V markers [26].
  • Analysis of the allele distribution in an interspecific mouse backcross by single-strand conformation polymorphism positioned the chromogranin A locus on Chromosome 12, between Igh-C and D12Pas1 [27].
  • The Tsu(d) gene is located very near the heavy chain constant-region genes, Igh-C, on the side toward the prealbumin gene, Pre-1 [28].
  • Our analysis of the variable region genes of MRL mice showed that the MRL/lpr D genes were similar to those of the C3H mouse (Igh-C allotype j) [29].
  • In the present study, we have refined the genetic map location of iv relative to the breakpoint of a reciprocal translocation, T(5;12)31H, involving the telomeric region of chromosome 12 distal to Igh-C and the proximal region of chromosome 5 [23].

Analytical, diagnostic and therapeutic context of Igh-C

  • Spurred by a recent report that mapped the iv gene to mouse chromosome 12 which was not excluded by our previous work, we used the polymerase chain reaction on our larger cohort to determine that the iv gene is indeed linked tightly to the Igh-C locus on this chromosome: we observed 0/156 recombinants between the iv and Igh-C loci [1].


  1. The murine situs inversus viscerum (iv) gene responsible for visceral asymmetry is linked tightly to the Igh-C cluster on chromosome 12. Hanzlik, A.J., Binder, M., Layton, W.M., Rowe, L., Layton, M., Taylor, B.A., Osemlak, M.M., Richards, J.E., Kurnit, D.M., Stewart, G.D. Genomics (1990) [Pubmed]
  2. Strain variations in the murine cellular immune response to the phenolic glycolipid I antigen of Mycobacterium leprae. Koster, F.T., Teuscher, C., Matzner, P., Umland, E., Yanagihara, D., Brennan, P.J., Tung, K.S. Infect. Immun. (1986) [Pubmed]
  3. DNA sequence associated with chromosome translocations in mouse plasmacytomas. Harris, L.J., D'Eustachio, P., Ruddle, F.H., Marcu, K.B. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  4. Mapping of the Fv-4 mouse gene controlling resistance to murine leukemia viruses. Ikeda, H., Sato, H., Odaka, T. Int. J. Cancer (1981) [Pubmed]
  5. Modification of T cell antinuclease idiotype expression by in vivo administration of anti-idiotype. Miller, G.G., Nadler, P.I., Hodes, R.J., Sachs, D.H. J. Exp. Med. (1982) [Pubmed]
  6. 5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains. Marcu, K.B., Banerji, J., Penncavage, N.A., Lang, R., Arnheim, N. Cell (1980) [Pubmed]
  7. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K., Honjo, T. Nature (2001) [Pubmed]
  8. Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci. Watson, W.C., Townes, A.S. J. Exp. Med. (1985) [Pubmed]
  9. Identification of Igh-C-linked determinants on suppressor T cell hybrids and factors specific for L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). Sorensen, C.M., Hayashi, R.J., Pierce, C.W. J. Exp. Med. (1985) [Pubmed]
  10. Rheumatoid factors in 129XB recombinant inbred strains. Igh-1-linked control of allotypic and isotypic specificities. Van Snick, J., Coutelier, J.P., Van Roost, E., Guénet, J.L. J. Exp. Med. (1984) [Pubmed]
  11. Immunogenetics of BCG-induced anergy in mice: control by genes linked to the Igh complex. Schrier, D.J., Sternick, J.L., Allen, E.M., Moore, V.L. J. Immunol. (1982) [Pubmed]
  12. The mouse Igh-1a and Igh-1b H chain constant regions are derived from two distinct isotypic genes. Jouvin-Marche, E., Morgado, M.G., Leguern, C., Voegtle, D., Bonhomme, F., Cazenave, P.A. Immunogenetics (1989) [Pubmed]
  13. The influence of Igh-1 genes on the class and subclass distribution of oxazolone-specific antibodies. László, G., Rajnavölgyi, E., Andó, I., Gergely, J. Immunogenetics (1985) [Pubmed]
  14. Restriction fragment length polymorphism and evolution of the mouse immunoglobulin constant region gamma loci. Morgado, M.G., Jouvin-Marche, E., Gris-Liebe, C., Bonhomme, F., Anand, R., Talwar, G.P., Cazenave, P.A. Immunogenetics (1993) [Pubmed]
  15. Genes for the mouse T cell alloantigens Tpre, Tthy, Tind, and Tsu are closely linked near Igh on chromosome 12. Owen, F.L., Riblet, R. J. Exp. Med. (1984) [Pubmed]
  16. T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch. Mongini, P.K., Paul, W.E., Metcalf, E.S. J. Exp. Med. (1982) [Pubmed]
  17. Igh-C allotype-linked control of anti-DNA production and clonotype expression in mice infected with Plasmodium yoelii. Yoshida, H., Fossati, L., Yoshida, M., Abdelmoula, M., Herrera, S., Merino, J., Lambert, P.H., Izui, S. J. Immunol. (1988) [Pubmed]
  18. Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity. Kroese, F.G., Butcher, E.C., Stall, A.M., Lalor, P.A., Adams, S., Herzenberg, L.A. Int. Immunol. (1989) [Pubmed]
  19. Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1. Yoshida, K., Matsuoka, M., Usuda, S., Mori, A., Ishizaka, K., Sakano, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  20. Nuclear matrix attachment occurs in several regions of the IgH locus. Cockerill, P.N. Nucleic Acids Res. (1990) [Pubmed]
  21. T15 idiotype expression in the murine response to phosphorylcholine is actively regulated by genes linked to the Igh-C locus. Stall, A.M., Quintáns, J., Loken, M.R. J. Immunol. (1986) [Pubmed]
  22. A linkage map of distal mouse chromosome 12. Cho, M., Villani, V., D'Eustachio, P. Mamm. Genome (1991) [Pubmed]
  23. Duplication/deficiency mapping of situs inversus viscerum (iv), a gene that determines left-right asymmetry in the mouse. McGrath, J., Horwich, A.L., Brueckner, M. Genomics (1992) [Pubmed]
  24. Coeliac disease: genetic, immunological and environmental factors in disease pathogenesis. Kagnoff, M.F. Scand. J. Gastroenterol. Suppl. (1985) [Pubmed]
  25. Idiotypic analysis of anti-I-Ak monoclonal antibodies. II. Detection of shared idiotopes on syngeneic BALB/c and allogeneic A.TH-derived anti-I-Ak mAb by BALB/c-derived anti-I-Ak anti-idiotypic mAb. Devaux, C.A., Phillips, M.L., Delovitch, T.L. J. Immunol. (1984) [Pubmed]
  26. Map position of Igh-Oxa gene within the Igh region of the DBA/2 mouse strain. Pelkonen, J., Karjalainen, K., Mäkelä, O., Taylor, B.A. J. Immunol. (1982) [Pubmed]
  27. Assignment of the chromogranin A (Chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6. Simon-Chazottes, D., Wu, H., Parmer, R.J., Rozansky, D.J., Szpirer, J., Levan, G., Kurtz, T.W., Szpirer, C., Guenet, J.L., O'Connor, D.T. Genomics (1993) [Pubmed]
  28. The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor. Owen, F.L., Riblet, R., Taylor, B.A. J. Exp. Med. (1981) [Pubmed]
  29. The Igh-V locus of MRL mice: restriction fragment length polymorphism in eleven strains of mice as determined with VH and D gene probes. Trepicchio, W., Barrett, K.J. J. Immunol. (1985) [Pubmed]
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