Gene Review:
Igh - immunoglobulin heavy chain complex
Mus musculus
- Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice. Park, S.S., Shaffer, A.L., Kim, J.S., duBois, W., Potter, M., Staudt, L.M., Janz, S. Cancer Res. (2005)
- Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Park, S.S., Kim, J.S., Tessarollo, L., Owens, J.D., Peng, L., Han, S.S., Tae Chung, S., Torrey, T.A., Cheung, W.C., Polakiewicz, R.D., McNeil, N., Ried, T., Mushinski, J.F., Morse, H.C., Janz, S. Cancer Res. (2005)
- Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A. Pawlitzky, I., Angeles, C.V., Siegel, A.M., Stanton, M.L., Riblet, R., Brodeur, P.H. J. Immunol. (2006)
- T-cell responsiveness to LCMV segregates as a single locus in crosses between BALB/cA and C.B-17 mice. Evidence for regulation by a gene outside the Igh region. Christensen, J.P., Marker, O., Thomsen, A.R. Scand. J. Immunol. (1993)
- Regulation of idiotope expression. IV. Genetic linkage of two D region-dependent T15 idiotopes to the IgH allotype. Cronkhite, R., Schulze, D., Cerny, J. J. Immunol. (1989)
- One heavy chain variable region gene segment subfamily in the BALB/c mouse contains 500-1000 or more members. Livant, D., Blatt, C., Hood, L. Cell (1986)
- AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Petersen, S., Casellas, R., Reina-San-Martin, B., Chen, H.T., Difilippantonio, M.J., Wilson, P.C., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D.R., Redon, C., Ried, T., Bonner, W.M., Honjo, T., Nussenzweig, M.C., Nussenzweig, A. Nature (2001)
- Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Strasser, A., Harris, A.W., Bath, M.L., Cory, S. Nature (1990)
- Enzymolysis of glomerular immune deposits in vivo with dextranase/protease ameliorates proteinuria, hematuria, and mesangial proliferation in murine experimental IgA nephropathy. Gesualdo, L., Ricanati, S., Hassan, M.O., Emancipator, S.N., Lamm, M.E. J. Clin. Invest. (1990)
- Factor XIII deficiency in BALB/c mice with plasmacytoma. Eipe, J., Yakulis, V., Costea, N. Cancer Res. (1977)
- Neonatal and adult primary B cells use the same germ-line VH and V kappa genes in their (T,G)-A-L-specific repertoire. Borriero, L., Giorgetti, C., Smith, G., Landry, D., Selsing, E., Zhukovsky, E., Press, J.L. J. Immunol. (1990)
- An epigenetically altered tumor cell vaccine. Khan, A.N., Magner, W.J., Tomasi, T.B. Cancer Immunol. Immunother. (2004)
- A molecular analysis of PGE receptor (EP) expression on normal and transformed B lymphocytes: coexpression of EP1, EP2, EP3beta and EP4. Fedyk, E.R., Ripper, J.M., Brown, D.M., Phipps, R.P. Mol. Immunol. (1996)
- Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus. Tokuhisa, T., Taniguchi, M. J. Exp. Med. (1982)
- The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor. Owen, F.L., Riblet, R., Taylor, B.A. J. Exp. Med. (1981)
- Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes. Mainville, C.A., Sheehan, K.M., Klaman, L.D., Giorgetti, C.A., Press, J.L., Brodeur, P.H. J. Immunol. (1996)
- T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch. Mongini, P.K., Paul, W.E., Metcalf, E.S. J. Exp. Med. (1982)
- H-40, an antigen controlled by an Igh linked gene and recognized by cytotoxic T lymphocytes. I. Genetic analysis of H-40 and distribution of its product on B cell tumors. Forman, J., Riblet, R., Brooks, K., Vitetta, E.S., Henderson, L.A. J. Exp. Med. (1984)
- Sites that direct nuclear compartmentalization are near the 5' end of the mouse immunoglobulin heavy-chain locus. Yang, Q., Riblet, R., Schildkraut, C.L. Mol. Cell. Biol. (2005)
- Influence of Igh-linked gene products on the generation of T helper cells in the response to sheep erythrocytes. Nutt, N., Haber, J., Wortis, H.H. J. Exp. Med. (1981)
- Immunogenetics of BCG-induced anergy in mice. Control by Igh- and H-2-linked genes. Callis, A.H., Schrier, D.J., David, C.S., Moore, V.L. Immunology (1983)
- T cell development in B cell-deficient mice. V. Stopping anti-mu treatment results in Igh-restricted expansion of the T suppressor cell repertoire concomitant with the development of normal immunoglobulin levels. Hayglass, K.T., Benacerraf, B., Sy, M.S. J. Exp. Med. (1986)
- Regulation of T15 idiotype dominance. II. Genes unlinked to the Igh locus regulate T15 dominance of the secondary adoptive transfer response to phosphocholine. Wicker, L.S., Guelde, G., Scher, I., Kenny, J.J. J. Immunol. (1985)
- VH families in the antibody response to p-azophenylarsonate: correlation between serology and amino acid sequence. Milner, E.C., Capra, J.D. J. Immunol. (1982)
- Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes. Sherman, L.A. J. Exp. Med. (1982)
- Genetics of the alpha 1,6-dextran response: expression of the QUPC52 idiotype in different inbred and congenic strains of mice. D'Hoostelaere, L., Potter, M. J. Immunol. (1982)
- Comparative analysis of human and mouse 3' Igh regulatory regions identifies distinctive structural features. Sepulveda, M.A., Garrett, F.E., Price-Whelan, A., Birshtein, B.K. Mol. Immunol. (2005)
- Variable region sequence analysis of anti-DNA antibodies: evidence for a family of closely related germ-line VH genes encoding lupus autoantibodies. Foster, M.H., Madaio, M.P., Barrett, K.J. DNA Cell Biol. (1992)
- Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Su, I.H., Basavaraj, A., Krutchinsky, A.N., Hobert, O., Ullrich, A., Chait, B.T., Tarakhovsky, A. Nat. Immunol. (2003)
- Genetic control of BCG-induced granulomatous inflammation in mice. Sternick, J.L., Schrier, D.J., Moore, V.L. Exp. Lung Res. (1983)
- Regulation of the replication of the murine immunoglobulin heavy chain gene locus: evaluation of the role of the 3' regulatory region. Michaelson, J.S., Ermakova, O., Birshtein, B.K., Ashouian, N., Chevillard, C., Riblet, R., Schildkraut, C.L. Mol. Cell. Biol. (1997)
- Stepwise activation of the immunoglobulin mu heavy chain gene locus. Chowdhury, D., Sen, R. EMBO J. (2001)
- Immunogenetics of BCG-induced anergy in mice: control by genes linked to the Igh complex. Schrier, D.J., Sternick, J.L., Allen, E.M., Moore, V.L. J. Immunol. (1982)
- Idiotypic analysis of anti-GAT antibodies. IX. Genetic mapping of the Gte idiotypic marker within the Igh-V locus. Ju, S.T., Dorf, M.E. J. Immunol. (1981)
- Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice, but Rb(6.15)-carrying tumors prefer Igk-Myc inversions over translocations. Silva, S., Wiener, F., Klein, G., Janz, S. Genes Chromosomes Cancer (2005)
- Similarities between transplantation antigens on methylcholanthrene-induced sarcomas and T-cell regulatory molecules. Flood, P.M., Deleo, A.B., Old, L.J., Gershon, R.K. Ann. N. Y. Acad. Sci. (1983)
- Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse. Foster, M.H., Sabbaga, J., Line, S.R., Thompson, K.S., Barrett, K.J., Madaio, M.P. J. Immunol. (1993)