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Gene Review

Igis1  -  immunoglobulin isotype 1

Mus musculus

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Disease relevance of Igis1


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Chemical compound and disease context of Igis1


Biological context of Igis1


Anatomical context of Igis1


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Analytical, diagnostic and therapeutic context of Igis1


  1. Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide-specific immunoglobulin isotype responses in vivo through distinct mechanisms. Colino, J., Shen, Y., Snapper, C.M. J. Exp. Med. (2002) [Pubmed]
  2. Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes. Stavnezer, J., Sirlin, S., Abbott, J. J. Exp. Med. (1985) [Pubmed]
  3. Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody. Waldor, M.K., Mitchell, D., Kipps, T.J., Herzenberg, L.A., Steinman, L. J. Immunol. (1987) [Pubmed]
  4. Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes. Potter, M.R., Noben-Trauth, N., Weis, J.H., Teuscher, C., Weis, J.J. Infect. Immun. (2000) [Pubmed]
  5. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Gu, H., Zou, Y.R., Rajewsky, K. Cell (1993) [Pubmed]
  6. Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency. Tahara, M., Pergolizzi, R.G., Kobayashi, H., Krause, A., Luettich, K., Lesser, M.L., Crystal, R.G. Nat. Med. (2004) [Pubmed]
  7. ICOS is critical for CD40-mediated antibody class switching. McAdam, A.J., Greenwald, R.J., Levin, M.A., Chernova, T., Malenkovich, N., Ling, V., Freeman, G.J., Sharpe, A.H. Nature (2001) [Pubmed]
  8. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K., Honjo, T. Nature (2001) [Pubmed]
  9. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A., Doherty, P.C., Grosveld, G., Paul, W.E., Ihle, J.N. Nature (1996) [Pubmed]
  10. Properties of monoclonal antibodies to nicotinic acetylcholine receptor from chick muscle. Mehraban, F., Kemshead, J.T., Dolly, J.O. Eur. J. Biochem. (1984) [Pubmed]
  11. A novel locus affecting serum levels of IgG2a maps to the murine H2 region. Matthews, V.B., Christiansen, F.T., Price, P. Eur. J. Immunogenet. (2000) [Pubmed]
  12. Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice. Brown, M.P., Topham, D.J., Sangster, M.Y., Zhao, J., Flynn, K.J., Surman, S.L., Woodland, D.L., Doherty, P.C., Farr, A.G., Pattengale, P.K., Brenner, M.K. Nat. Med. (1998) [Pubmed]
  13. The relationship between surface immunoglobulin isotype and the immune function of murine B lymphocytes. V. High affinity secondary antibody responses are transferred by both IgD-positive and IgD-negative memory B cells. Lafrenz, D., Strober, S., Vitetta, E. J. Immunol. (1981) [Pubmed]
  14. The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. IV. Role of IgD-bearing cells in the propagation of immunologic memory. Zan-Bar, I., Strober, S., Vitetta, E.S. J. Immunol. (1979) [Pubmed]
  15. Antigen-initiated B lymphocyte differentiation. XX. Colony-forming B lymphocytes are not identical with the intermediate, "pre-progenitor" subset of primary or secondary B cells. Jennings, G., Shortman, K. J. Immunol. (1982) [Pubmed]
  16. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in alpha beta(+) T cells. Wen, L., Roberts, S.J., Viney, J.L., Wong, F.S., Mallick, C., Findly, R.C., Peng, Q., Craft, J.E., Owen, M.J., Hayday, A.C. Nature (1994) [Pubmed]
  17. Overexpression of branched O-linked oligosaccharides on T cell surface glycoproteins impairs humoral immune responses in transgenic mice. Tsuboi, S., Fukuda, M. J. Biol. Chem. (1998) [Pubmed]
  18. Opsonization of Cryptococcus neoformans by a family of isotype-switch variant antibodies specific for the capsular polysaccharide. Schlageter, A.M., Kozel, T.R. Infect. Immun. (1990) [Pubmed]
  19. Immunoglobulin isotype regulation by antigen-presenting cells in vivo. De Becker, G., Sornasse, T., Nabavi, N., Bazin, H., Tielemans, F., Urbain, J., Leo, O., Moser, M. Eur. J. Immunol. (1994) [Pubmed]
  20. Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice. Rahemtulla, A., Kündig, T.M., Narendran, A., Bachmann, M.F., Julius, M., Paige, C.J., Ohashi, P.S., Zinkernagel, R.M., Mak, T.W. Eur. J. Immunol. (1994) [Pubmed]
  21. Immunoglobulin isotype in the murine response to polysaccharide antigens. Moreno, C., Esdaile, J. Eur. J. Immunol. (1983) [Pubmed]
  22. Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei. Radwanska, M., Magez, S., Michel, A., Stijlemans, B., Geuskens, M., Pays, E. Infect. Immun. (2000) [Pubmed]
  23. Analysis of immunoglobulin isotype blood levels, splenic B-cell phenotypes, and spleen cell immunoglobulin gene expression in mice infected with lactate dehydrogenase-elevating virus. Hovinen, D.E., Bradley, D.S., Cafruny, W.A. Viral Immunol. (1990) [Pubmed]
  24. 4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae. Wu, Z.Q., Khan, A.Q., Shen, Y., Wolcott, K.M., Dawicki, W., Watts, T.H., Mittler, R.S., Snapper, C.M. Infect. Immun. (2003) [Pubmed]
  25. Non-major histocompatibility complex control of antibody isotype and Th1 versus Th2 cytokines during experimental infection of mice with Mycobacterium avium. Nagabhushanam, V., Cheers, C. Infect. Immun. (2001) [Pubmed]
  26. CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Samardzic, T., Gerlach, J., Muller, K., Marinkovic, D., Hess, J., Nitschke, L., Wirth, T. Eur. J. Immunol. (2002) [Pubmed]
  27. Anti-mouse red blood cell monoclonal antibodies use functionally rearranged genes from the VH J558 family and are derived from the CD5- B-lymphocyte subpopulation. Scott, B.B., Sadigh, S., Stow, M., Mageed, R.A., Andrew, E.M., Maini, R.N. Immunology (1993) [Pubmed]
  28. Immunoglobulin isotype switching in xid mice. Brorson, K.A., Krasnokutsky, M.V., Stein, K.E. Mol. Immunol. (1995) [Pubmed]
  29. Reconstitution of lymphoid development and function in ZAP-70-deficient mice following gene transfer into bone marrow cells. Otsu, M., Steinberg, M., Ferrand, C., Merida, P., Rebouissou, C., Tiberghien, P., Taylor, N., Candotti, F., Noraz, N. Blood (2002) [Pubmed]
  30. Passive immunization against Cryptococcus neoformans with an isotype-switch family of monoclonal antibodies reactive with cryptococcal polysaccharide. Sanford, J.E., Lupan, D.M., Schlageter, A.M., Kozel, T.R. Infect. Immun. (1990) [Pubmed]
  31. Immunoglobulin isotype expression of normal pre-B cells as determined by immunofluorescence. Kubagawa, H., Gathings, W.E., Levitt, D., Kearney, J.F., Cooper, M.D. J. Clin. Immunol. (1982) [Pubmed]
  32. Characterization of Sicilian strains of spotted fever group rickettsiae by using monoclonal antibodies. Vitale, G., Di Stefano, R., Damiani, G., Mansueto, S. J. Clin. Microbiol. (1989) [Pubmed]
  33. Rapid generation of monoclonal antibody-secreting hybridomas against African horse sickness virus by in vitro immunization and the fusion/cloning technique. Stäuber, N., Kihm, U., McCullough, K.C. J. Immunol. Methods (1993) [Pubmed]
  34. Mucosal immunogenicity and adjuvant activity of the recombinant A subunit of the Escherichia coli heat-labile enterotoxin. De Haan, L., Holtrop, M., Verweij, W.R., Agsteribbe, E., Wilschut, J. Immunology (1999) [Pubmed]
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