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Gene Review

SCN11A  -  sodium channel, voltage gated, type XI...

Homo sapiens

Synonyms: FEPS3, HSAN7, NAV1.9, NaN, Nav1.9, ...
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Disease relevance of SCN11A


Psychiatry related information on SCN11A

  • In this chapter, evidence of an important role for post-translational regulation of Nav1.9 in setting pain thresholds is presented [4].

High impact information on SCN11A

  • NaN/Nav1.9 carried LVA currents into type-I (CI) and type-II (CII) small nociceptors and medium-Adelta-like nociceptive cells but not in low-threshold mechanoreceptors, including putative Down-hair (D-hair) and Aalpha/beta cells [5].
  • Low voltage-activated (LVA) T-type Ca(2+) (I(Ca)T) and NaN/Nav1.9 currents regulate DRG neurons by setting the threshold for the action potential [5].
  • NaN/Nav1.9 was inhibited by inorganic I(Ca) blockers as follows (IC(50), muM): La(3+) (46) > Cd(2+) (233) > Ni(2+) (892) and by mibefradil, a non-dihydropyridine I(Ca)T antagonist [5].
  • SNS and SNS2 are found both in NGF-responsive and GDNF-responsive C-fibers and many of these cells also express the capsaicin receptor VR1 [1].
  • About half of C-fiber DRG neurons express either SNS or SNS2, and in most, the channels are colocalized [1].

Biological context of SCN11A


Anatomical context of SCN11A


Other interactions of SCN11A

  • Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states [9].
  • Remarkably, two voltage-gated sodium channel genes (Nav1.8 and Nav1.9) are expressed selectively in damage-sensing peripheral neurons, while a third channel (Nav1.7) is found predominantly in sensory and sympathetic neurons [10].

Analytical, diagnostic and therapeutic context of SCN11A

  • Pharmacological Dissection and Distribution of NaN/Nav1.9, T-type Ca2+ Currents, and Mechanically Activated Cation Currents in Different Populations of DRG Neurons [5].


  1. Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Amaya, F., Decosterd, I., Samad, T.A., Plumpton, C., Tate, S., Mannion, R.J., Costigan, M., Woolf, C.J. Mol. Cell. Neurosci. (2000) [Pubmed]
  2. SNS/PN3 and SNS2/NaN sodium channel-like immunoreactivity in human adult and neonate injured sensory nerves. Yiangou, Y., Birch, R., Sangameswaran, L., Eglen, R., Anand, P. FEBS Lett. (2000) [Pubmed]
  3. Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2. Bucknill, A.T., Coward, K., Plumpton, C., Tate, S., Bountra, C., Birch, R., Sandison, A., Hughes, S.P., Anand, P. Spine. (2002) [Pubmed]
  4. Ion channel activities implicated in pathological pain. Wood, J.N., Abrahamsen, B., Baker, M.D., Boorman, J.D., Donier, E., Drew, L.J., Nassar, M.A., Okuse, K., Seereeram, A., Stirling, C.L., Zhao, J. Novartis Found. Symp. (2004) [Pubmed]
  5. Pharmacological Dissection and Distribution of NaN/Nav1.9, T-type Ca2+ Currents, and Mechanically Activated Cation Currents in Different Populations of DRG Neurons. Coste, B., Crest, M., Delmas, P. J. Gen. Physiol. (2007) [Pubmed]
  6. Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. Dib-Hajj, S.D., Tyrrell, L., Escayg, A., Wood, P.M., Meisler, M.H., Waxman, S.G. Genomics (1999) [Pubmed]
  7. Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A. Jeong, S.Y., Goto, J., Hashida, H., Suzuki, T., Ogata, K., Masuda, N., Hirai, M., Isahara, K., Uchiyama, Y., Kanazawa, I. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  8. Expression profiles of voltage-gated Na(+) channel alpha-subunit genes in rat and human prostate cancer cell lines. Diss, J.K., Archer, S.N., Hirano, J., Fraser, S.P., Djamgoz, M.B. Prostate (2001) [Pubmed]
  9. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states. Coward, K., Plumpton, C., Facer, P., Birch, R., Carlstedt, T., Tate, S., Bountra, C., Anand, P. Pain (2000) [Pubmed]
  10. Voltage-gated sodium channels and pain pathways. Wood, J.N., Boorman, J.P., Okuse, K., Baker, M.D. J. Neurobiol. (2004) [Pubmed]
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