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MeSH Review


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Disease relevance of Sciatica


High impact information on Sciatica


Chemical compound and disease context of Sciatica

  • In this report, our patient presented with sciatica that responded poorly to epidural steroid injection and only transiently to piriformis injection [10].
  • MATERIALS AND METHODS: Thirty-six volunteers without LBP and/or sciatica (18 with no symptoms in their lifetime and 18 who were pain free for at least 6 months) were examined with sagittal and axial T2-weighted fast spin-echo (SE) and sagittal gadolinium-enhanced T1-weighted fast SE imaging [8].
  • Comparison of injectable formulations of tiaprofenic acid and ketoprofen in acute lumbar sciatica. Single-blind randomised trial [11].
  • METHODS: Ten healthy individuals with sciatica underwent a short insulin tolerance test before and twice following (at 24 h and 1 week) a caudal epidural containing 80 mg triamcinolone [12].
  • In this randomized, double-blind, double-dummy trial, 113 patients with acute sciatica were treated with a single 15-mg dose of meloxicam given intramuscularly (n = 54) or orally (n = 59) [13].

Biological context of Sciatica


Anatomical context of Sciatica


Gene context of Sciatica


Analytical, diagnostic and therapeutic context of Sciatica


  1. Reversible cause of back pain and sciatica in rheumatoid arthritis: an apophyseal joint cyst. Jacob, J.R., Weisman, M.H., Mink, J.H., Metzger, A.L., Feldman, G.R., Dorfman, H.D., Blinderman, E.E., Resnick, D. Arthritis Rheum. (1986) [Pubmed]
  2. Treatment of backache with spinal injections of local anesthetics, spinal and systemic steroids. A review. Kepes, E.R., Duncalf, D. Pain (1985) [Pubmed]
  3. A controlled biochemical and immunohistochemical study of human synovial-type (group II) phospholipase A2 and inflammatory cells in macroscopically normal, degenerated, and herniated human lumbar disc tissues. Grönblad, M., Virri, J., Rönkkö, S., Kiviranta, I., Vanharanta, H., Seitsalo, S., Rashbaum, R.F., Guyer, R.D. Spine. (1996) [Pubmed]
  4. Spinal epidural abscess following steroid injection for sciatica. Case report. Chan, S.T., Leung, S. Spine. (1989) [Pubmed]
  5. Gadolinium-DTPA enhancement of symptomatic nerve roots in MRI of the lumbar spine. Tyrrell, P.N., Cassar-Pullicino, V.N., McCall, I.W. European radiology. (1998) [Pubmed]
  6. Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. Carette, S., Leclaire, R., Marcoux, S., Morin, F., Blaise, G.A., St-Pierre, A., Truchon, R., Parent, F., Levésque, J., Bergeron, V., Montminy, P., Blanchette, C. N. Engl. J. Med. (1997) [Pubmed]
  7. Radiologic phenotypes in lumbar MR imaging for a gene defect in the COL9A3 gene of type IX collagen. Karppinen, J., Pääkkö, E., Paassilta, P., Lohiniva, J., Kurunlahti, M., Tervonen, O., Nieminen, P., Göring, H.H., Malmivaara, A., Vanharanta, H., Ala-Kokko, L. Radiology. (2003) [Pubmed]
  8. Annular tears and disk herniation: prevalence and contrast enhancement on MR images in the absence of low back pain or sciatica. Stadnik, T.W., Lee, R.R., Coen, H.L., Neirynck, E.C., Buisseret, T.S., Osteaux, M.J. Radiology. (1998) [Pubmed]
  9. Efficacy of epidural steroid injections for low-back pain and sciatica: a systematic review of randomized clinical trials. Koes, B.W., Scholten, R.J., Mens, J.M., Bouter, L.M. Pain (1995) [Pubmed]
  10. Sciatic entrapment neuropathy associated with an anomalous piriformis muscle. Sayson, S.C., Ducey, J.P., Maybrey, J.B., Wesley, R.L., Vermilion, D. Pain (1994) [Pubmed]
  11. Comparison of injectable formulations of tiaprofenic acid and ketoprofen in acute lumbar sciatica. Single-blind randomised trial. Borms, T. Drugs (1988) [Pubmed]
  12. Glucocorticoid epidural for sciatica: metabolic and endocrine sequelae. Ward, A., Watson, J., Wood, P., Dunne, C., Kerr, D. Rheumatology (Oxford, England) (2002) [Pubmed]
  13. Comparison of the onset and intensity of action of intramuscular meloxicam and oral meloxicam in patients with acute sciatica. Auvinet, B., Ziller, R., Appelboom, T., Velicitat, P. Clinical therapeutics. (1995) [Pubmed]
  14. Efficacy of nerve root versus interspinous injections of glucocorticoids in the treatment of disk-related sciatica. A pilot, prospective, randomized, double-blind study. Kolsi, I., Delecrin, J., Berthelot, J.M., Thomas, L., Prost, A., Maugars, Y. Joint, bone, spine : revue du rhumatisme. (2000) [Pubmed]
  15. Charcot-Marie-Tooth disease. Martel, J., Mierau, D., Donat, J. Journal of manipulative and physiological therapeutics. (1995) [Pubmed]
  16. Multiple peripheral nerve compressions related to malignantly transformed hereditary multiple exostoses. Paik, N.J., Han, T.R., Lim, S.J. Muscle Nerve (2000) [Pubmed]
  17. Diffusion of intramuscular ketoprofen into the cerebrospinal fluid. Netter, P., Lapicque, F., Bannwarth, B., Tamisier, J.N., Thomas, P., Royer, R.J. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  18. Altered lower limb vascular perfusion in patients with sciatica secondary to disc herniation. Maigne, J.Y., Treuil, C., Chatellier, G. Spine. (1996) [Pubmed]
  19. William Jason Mixter (1880-1958). Ushering in the "dynasty of the disc". Parisien, R.C., Ball, P.A. Spine. (1998) [Pubmed]
  20. Markers of nerve tissue injury in the cerebrospinal fluid in patients with lumbar disc herniation and sciatica. Brisby, H., Olmarker, K., Rosengren, L., Cederlund, C.G., Rydevik, B. Spine. (1999) [Pubmed]
  21. Low levels of nitric oxide (NO) in systemic sclerosis: inducible NO synthase production is decreased in cultured peripheral blood monocyte/macrophage cells. Allanore, Y., Borderie, D., Hilliquin, P., Hernvann, A., Levacher, M., Lemaréchal, H., Ekindjian, O.G., Kahan, A. Rheumatology (Oxford, England) (2001) [Pubmed]
  22. Human nucleus pulposis can respond to a pro-inflammatory stimulus. Burke, J.G., G Watson, R.W., Conhyea, D., McCormack, D., Dowling, F.E., Walsh, M.G., Fitzpatrick, J.M. Spine. (2003) [Pubmed]
  23. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. Burke, J.G., Watson, R.W., McCormack, D., Dowling, F.E., Walsh, M.G., Fitzpatrick, J.M. The Journal of bone and joint surgery. British volume. (2002) [Pubmed]
  24. Infliximab attenuates immunoreactivity of brain-derived neurotrophic factor in a rat model of herniated nucleus pulposus. Onda, A., Murata, Y., Rydevik, B., Larsson, K., Kikuchi, S., Olmarker, K. Spine. (2004) [Pubmed]
  25. Magnetic resonance imaging findings in relation to the COL9A2 tryptophan allele among patients with sciatica. Karppinen, J., Pääkkö, E., Räinä, S., Tervonen, O., Kurunlahti, M., Nieminen, P., Ala-Kokko, L., Malmivaara, A., Vanharanta, H. Spine. (2002) [Pubmed]
  26. Comparison of caudal steroid epidural with targeted steroid placement during spinal endoscopy for chronic sciatica: a prospective, randomized, double-blind trial. Dashfield, A.K., Taylor, M.B., Cleaver, J.S., Farrow, D. British journal of anaesthesia. (2005) [Pubmed]
  27. Immunoglobulin E antibodies to papaya proteinases and their relevance to chemonucleolysis. Dando, P.M., Sharp, S.L., Buttle, D.J., Barrett, A.J. Spine. (1995) [Pubmed]
  28. The diffusion of pirprofen into the cerebrospinal fluid in man. Zecca, L., Broggini, M., Pirola, R., Campi, R., Ferrario, P., Bichisao, E., Maresca, V. Eur. J. Clin. Pharmacol. (1988) [Pubmed]
  29. Lamotrigine for intractable sciatica: correlation between dose, plasma concentration and analgesia. Eisenberg, E., Damunni, G., Hoffer, E., Baum, Y., Krivoy, N. European journal of pain (London, England) (2003) [Pubmed]
  30. Meloxicam: a review of its pharmacokinetics, efficacy and tolerability following intramuscular administration. Euller-Ziegler, L., Vélicitat, P., Bluhmki, E., Türck, D., Scheuerer, S., Combe, B. Inflamm. Res. (2001) [Pubmed]
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