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Gene Review

Agtr1b  -  angiotensin II receptor, type 1b

Mus musculus

Synonyms: AT1B, AT2R1B, AT3, Agtr-1b, Angiotensin II type-1B receptor, ...
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Psychiatry related information on Agtr1b

  • RESULTS: Tacrine completely blocked the avoidance-learning deficit caused by Sco 0.5, AT3 and Atr 5, or Ani 50 [1].
  • The avoidance-memory deficit caused by Sco 0.05-5 or Atr 5 was completely or partly attenuated by tacrine, which did not antagonize the memory deficit elicited by Sco and Atr 50, AT3 5 and 50, and Ani 50 [1].

High impact information on Agtr1b

  • Agtr1a-/-, Agtr1b-/- mice are characterized by normal in utero survival but decreased ex utero survival rate [2].
  • Agtr1b -/- mice are healthy, without an abnormal phenotype [3].
  • Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II [3].
  • A role of Ang II via AT1B or AT2 receptors is still a possibility that cannot be ruled out by the present experimental approach [4].
  • Inhibition of the response by AT1 receptor antagonist suggests mediation by the AT1B receptor in these animals [5].

Biological context of Agtr1b


Anatomical context of Agtr1b


Associations of Agtr1b with chemical compounds

  • Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b [2].
  • Agtr1a -/-Agtr1b -/- mice have no systemic pressor response to infusions of angiotensin II, but they respond normally to another vasoconstrictor, epinephrine [3].
  • Our results demonstrate that Ang II causes calcium signaling in AT1A-deficient VSMCs that is mediated by an endogenous losartan-sensitive AT1B receptor [8].
  • This pressor response was not blocked by pretreatment with sympatholytic agents but was completely inhibited by the AT1-receptor antagonists, losartan and candesartan, suggesting that it is directly mediated by AT1B receptors [11].
  • On recall session (d 2) the walking and rearing behaviors in the 18- and 28-d-old mice receiving Atr, Sco, and AT3 on d 1 were higher than those in the mice receiving saline [12].

Other interactions of Agtr1b


Analytical, diagnostic and therapeutic context of Agtr1b


  1. Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine. Pan, S.Y., Han, Y.F. Acta Pharmacol. Sin. (2000) [Pubmed]
  2. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida, S., Matsusaka, T., Chen, X., Okubo, S., Niimura, F., Nishimura, H., Fogo, A., Utsunomiya, H., Inagami, T., Ichikawa, I. J. Clin. Invest. (1998) [Pubmed]
  3. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Oliverio, M.I., Kim, H.S., Ito, M., Le, T., Audoly, L., Best, C.F., Hiller, S., Kluckman, K., Maeda, N., Smithies, O., Coffman, T.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria. Benigni, A., Corna, D., Zoja, C., Longaretti, L., Gagliardini, E., Perico, N., Coffman, T.M., Remuzzi, G. J. Am. Soc. Nephrol. (2004) [Pubmed]
  5. Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice. Ruan, X., Oliverio, M.I., Coffman, T.M., Arendshorst, W.J. J. Am. Soc. Nephrol. (1999) [Pubmed]
  6. A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Le, T.H., Oliverio, M.I., Kim, H.S., Salzler, H., Dash, R.C., Howell, D.N., Smithies, O., Bronson, S., Coffman, T.M. Physiol. Genomics (2004) [Pubmed]
  7. Mouse angiotensin receptor genes Agtr1a and Agtr1b map to chromosomes 13 and 3. MacTaggart, T.E., Ito, M., Smithies, O., John, S.W. Mamm. Genome (1997) [Pubmed]
  8. Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. Zhu, Z., Zhang, S.H., Wagner, C., Kurtz, A., Maeda, N., Coffman, T., Arendshorst, W.J. Hypertension (1998) [Pubmed]
  9. Targeting deletion of angiotensin type 1B receptor gene in the mouse. Chen, X., Li, W., Yoshida, H., Tsuchida, S., Nishimura, H., Takemoto, F., Okubo, S., Fogo, A., Matsusaka, T., Ichikawa, I. Am. J. Physiol. (1997) [Pubmed]
  10. Differential expression of angiotensin receptor 1A and 1B in mouse. Burson, J.M., Aguilera, G., Gross, K.W., Sigmund, C.D. Am. J. Physiol. (1994) [Pubmed]
  11. Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. Oliverio, M.I., Best, C.F., Kim, H.S., Arendshorst, W.J., Smithies, O., Coffman, T.M. Am. J. Physiol. (1997) [Pubmed]
  12. Belladonna alkaloids-induced behavioral changes and amnesia on open-field and step-through in 18-, 28-, and 38-day-old mice. Pan, S.Y., Han, Y.F., Xu, Q.P., Liu, M.Y., Ma, H.Z., Ding, W.J., Zhu, R.L. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1998) [Pubmed]
  13. Angiotensin II receptor types 1A, 1B, and 2 in murine neuroblastoma Neuro-2a cells. Hoffmann, A., Cool, D.R. J. Recept. Signal Transduct. Res. (2003) [Pubmed]
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