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Gene Review

Krt14l  -  keratin 14-like

Rattus norvegicus

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Disease relevance of Krt14


High impact information on Krt14


Biological context of Krt14

  • Utilizing a combination of 2-acetylaminofluorene (2-AAF) administration and partial hepatectomy to activate liver regeneration by proliferation of oval cells, we examined the modulation of K14 as well as alpha-fetoprotein (AFP) expression in proliferating oval cells and lineages hypothesized to be derived herefrom [3].
  • While radiation strongly affected the expression of stress response, immune/inflammation and nucleic acid metabolism genes, the retinoid most strongly affected proliferation-related genes, including some significant reversals, such as, keratin 14, retinol binding protein, and calcium binding proteins [5].
  • Immunohistochemical detection of the expression of keratin 14 in the lingual epithelium of rats during the morphogenesis of filiform papillae [6].

Anatomical context of Krt14

  • More than 99% of the cells in the GS I-negative fraction lacked cell surface alpha-galactosyl end groups, 98% did not stain for keratin 14-related protein, 54% had significant numbers of AB-PAS-stained cytoplasmic granules, and 16% were identified as ciliated cells [7].
  • Previous studies showed that Griffonia simplicifolia I-isolectin B4 (GS I-B4) and monoclonal antibodies (mAbs) against keratin 14 labeled basal cells in the adult rat trachea while other mAbs specifically stained secretory and/or ciliated cells [8].
  • Keratin 14 (K14) expression has recently been demonstrated in cell lines of non-parenchymal hepatic origin (Bisgaard et al., 1993, Mol. Carcinog., 7:60-66; Bisgaard et al., 1991, J. Cell. Physiol., 147:333-343) [3].
  • Neither K14 nor AFP transcripts were detected in bile ducts or mature hepatocytes at any time during oval cell proliferation and reconstitution of the liver mass [3].
  • A small number of the MECs expressed weak K14 immunoreactivity from the time when the acinus-intercalated duct structure was established, i.e., at 21 days in utero in the sublingual gland, at 5 days after birth in the perotid gland and after 5 weeks post-natally in the submandibular gland [9].

Associations of Krt14 with chemical compounds

  • From 48 to 96 h, cells derived from either fraction were ultrastructurally indistinguishable; they were poorly differentiated and highly proliferative, and all expressed Gal and K14 [10].

Other interactions of Krt14

  • In the AP keratin 14 was basally localized by 1 day postnatal but keratin 5 and 7 did not colocalize to the basal cells until days 9 and 12, respectively [11].

Analytical, diagnostic and therapeutic context of Krt14


  1. Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. Liu, C.G., Zhang, L., Jiang, Y., Chatterjee, D., Croce, C.M., Huebner, K., Fong, L.Y. Cancer Res. (2005) [Pubmed]
  2. Phenotype and differentiation potential of a novel rat tracheal epithelial cell line. Doherty, M.M., Liu, J., Randell, S.H., Carter, C.A., Davis, C.W., Nettesheim, P., Ferriola, P.C. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  3. Modulation of keratin 14 and alpha-fetoprotein expression during hepatic oval cell proliferation and liver regeneration. Bisgaard, H.C., Nagy, P., Ton, P.T., Hu, Z., Thorgeirsson, S.S. J. Cell. Physiol. (1994) [Pubmed]
  4. Expression of phenotypic markers during regeneration of rat tracheal epithelium following mechanical injury. Shimizu, T., Nishihara, M., Kawaguchi, S., Sakakura, Y. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  5. The action of a dietary retinoid on gene expression and cancer induction in electron-irradiated rat skin. Burns, F.J., Chen, S., Xu, G., Wu, F., Tang, M.S. J. Radiat. Res. (2002) [Pubmed]
  6. Immunohistochemical detection of the expression of keratin 14 in the lingual epithelium of rats during the morphogenesis of filiform papillae. Iwasaki, S., Aoyagi, H., Yoshizawa, H. Arch. Oral Biol. (2003) [Pubmed]
  7. Properties of rat tracheal epithelial cells separated based on expression of cell surface alpha-galactosyl end groups. Randell, S.H., Comment, C.E., Ramaekers, F.C., Nettesheim, P. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  8. Expression of "cell-type-specific" markers during rat tracheal epithelial regeneration. Shimizu, T., Nettesheim, P., Ramaekers, F.C., Randell, S.H. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  9. Immunohistochemistry of myoepithelial cells during development of the rat salivary glands. Ogawa, Y., Yamauchi, S., Ohnishi, A., Ito, R., Ijuhin, N. Anat. Embryol. (1999) [Pubmed]
  10. Growth and differentiation of tracheal epithelial progenitor cells. Liu, J.Y., Nettesheim, P., Randell, S.H. Am. J. Physiol. (1994) [Pubmed]
  11. Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle. Hayward, S.W., Baskin, L.S., Haughney, P.C., Cunha, A.R., Foster, B.A., Dahiya, R., Prins, G.S., Cunha, G.R. Acta anatomica. (1996) [Pubmed]
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