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MTFMT  -  mitochondrial methionyl-tRNA...

Homo sapiens

Synonyms: COXPD15, FMT, FMT1, Methionyl-tRNA formyltransferase, mitochondrial, MtFMT
 
 
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Disease relevance of MTFMT

  • The aim of this study was to evaluate the clinical application potential of FMT for patients with brain tumors [1].
  • FMT tumor uptake at 60 min postinjection in mice with LS180 rectal cancer, RPM11788 B-cell lymphoma and MCF7 mammary cell carcinoma was assessed, and the results were compared with 18F-fluoro-2-deoxy-D-glucose (FDG) tumor uptake [2].
  • Surgery on two, three, or four extraocular muscles was performed based on the magnitude of torsion measured after FMT surgery [3].
  • FMT PET is valuable for differentiating gliomatosis cerebri from non-neoplastic diseases showing similar diffuse high signal on T2-weighted images and little contrast enhancement [4].
  • Subjective data regarding diplopia and tilted vision after FMT and muscle surgery were available on an additional 10 patients (n = 53 + 10 = 63) [3].
 

High impact information on MTFMT

  • We conclude that little behavioral improvement can be seen until AADC activity reaches a level that is no longer rate limiting for conversion of clinical doses of l-Dopa into dopamine or for trapping of the PET tracer FMT [5].
  • In 13 patients, FMT uptake in the brain tumor was compared with 18F-fluorodeoxyglucose (FDG) [1].
  • We have developed 18F-labeled alpha-methyl tyrosine (FMT) for PET imaging [1].
  • The substrate specificity of FMT, coupled with its limited in vivo peripheral metabolism, makes it a useful, new biochemical probe for in vivo, noninvasive evaluation of central dopaminergic mechanisms [6].
  • It is apparently due to inability of FMT to catalyze the hydrolysis of 10-formyl-THF in the absence of the cosubstrate of the transferase reaction despite the high similarity of the catalytic centers of the two enzymes [7].
 

Chemical compound and disease context of MTFMT

 

Biological context of MTFMT

  • The tracer 6-[18F]fluoro-L-m-tyrosine (FMT) was studied with regard to its biochemistry and kinetics, as well as its utility in evaluating brain dopaminergic function in primates before and after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment using positron emission tomography (PET) [9].
  • A three compartment three kinetic rate constant model for FMT uptake revealed reduced FMT decarboxylation (k3) in ipsilateral caudate and putamen after unilateral MPTP although a further decrease was not evident after intravenous MPTP [9].
  • Increasing venous pressure by 10 and 20 mmHg produced changes in FMT and PT which, as estimated by the two methods, were not significantly different [10].
  • A pilot survey showed moderate gene frequency differentiation among meadows (local populations; FLM = 0.1) and among metapopulations c. 30 km apart (FMT = 0.2) [11].
  • In a tissue that exhibits net transcapillary protein transport, total transcapillary fluid movement (FMT) is defined according to the law of mass conservation as: FMT = FA (CV - CA)/CV + PT/CV where FA is arterial plasma flow and CV and CA are respectively venous and arterial protein concentration [10].
 

Anatomical context of MTFMT

  • The FMT signal accumulated preferentially in dopaminergic areas such as caudate and putamen [9].
  • The lateral side of the base of the second (SMT), third (TMT), and fourth (FMT) metatarsal bones displays constant and distinct grooves [12].
 

Analytical, diagnostic and therapeutic context of MTFMT

  • 4-[18F]Fluoro-L-m-tyrosine (FMT), a biochemical probe of striatal dopaminergic function, has been synthesized as an L-3,4-dihydroxyphenylalanine analog for positron emission tomography [6].
  • In 3 healthy volunteers, whole-body imaging and urinary and plasma analysis were conducted for the assessment of the biodistribution of FMT [1].
  • Positron emission tomography analysis of brain tissue in monkeys (Macaca nemestrina) after intravenous injection of FMT revealed a true time-dependent, specific accumulation of radioactivity in striatum, with a striatum/cerebellum (nonspecific) ratio of 4 at 180 min [6].
  • METHODS: Raw perfusion images were used to generate maps of time to peak (TTP), mean transit time (MTT), time to peak of the impulse response (Tmax) and first moment transit time (FMT) [13].
  • OBJECTIVE: The relative utility of various preoperative diagnostic imaging modalities, including PET (utilizing FDG and FMT), CT, and MR imaging, for evaluation of lipoma and liposarcoma, especially well-differentiated liposarcoma, was investigated [14].

References

  1. 18F alpha-methyl tyrosine PET studies in patients with brain tumors. Inoue, T., Shibasaki, T., Oriuchi, N., Aoyagi, K., Tomiyoshi, K., Amano, S., Mikuni, M., Ida, I., Aoki, J., Endo, K. J. Nucl. Med. (1999) [Pubmed]
  2. Biodistribution studies on L-3-[fluorine-18]fluoro-alpha-methyl tyrosine: a potential tumor-detecting agent. Inoue, T., Tomiyoshi, K., Higuichi, T., Ahmed, K., Sarwar, M., Aoyagi, K., Amano, S., Alyafei, S., Zhang, H., Endo, K. J. Nucl. Med. (1998) [Pubmed]
  3. Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study. Freedman, S.F., Holgado, S., Enyedi, L.B., Toth, C.A. Am. J. Ophthalmol. (2003) [Pubmed]
  4. Gliomatosis cerebri evaluated by 18Falpha-methyl tyrosine positron-emission tomography. Sato, N., Inoue, T., Tomiyoshi, K., Aoki, J., Oriuchi, N., Takahashi, A., Otani, T., Kurihara, H., Sasaki, T., Endo, K. Neuroradiology. (2003) [Pubmed]
  5. A Dose-Ranging Study of AAV-hAADC Therapy in Parkinsonian Monkeys. Forsayeth, J.R., Eberling, J.L., Sanftner, L.M., Zhen, Z., Pivirotto, P., Bringas, J., Cunningham, J., Bankiewicz, K.S. Mol. Ther. (2006) [Pubmed]
  6. 4-[18F]fluoro-L-m-tyrosine: an L-3,4-dihydroxyphenylalanine analog for probing presynaptic dopaminergic function with positron emission tomography. Melega, W.P., Perlmutter, M.M., Luxen, A., Nissenson, C.H., Grafton, S.T., Huang, S.C., Phelps, M.E., Barrio, J.R. J. Neurochem. (1989) [Pubmed]
  7. Modular organization of FDH: Exploring the basis of hydrolase catalysis. Reuland, S.N., Vlasov, A.P., Krupenko, S.A. Protein Sci. (2006) [Pubmed]
  8. A randomized clinical trial of combination chemotherapy in advanced colorectal cancer. O'Connell, M.J., Schutt, A.J., Moertel, C.G., Rubin, J., Hahn, R.G., Scott, M. Am. J. Clin. Oncol. (1987) [Pubmed]
  9. 6-[18F]fluoro-L-m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates. Jordan, S., Eberling, J.L., Bankiewicz, K.S., Rosenberg, D., Coxson, P.G., VanBrocklin, H.F., O'Neil, J.P., Emborg, M.E., Jagust, W.J. Brain Res. (1997) [Pubmed]
  10. Mass-balance approach for estimating transcapillary fluid and protein movement. Friedman, J.J., Szwed, J.J., Johns, B.L. Am. J. Physiol. (1982) [Pubmed]
  11. Developing microsatellite markers for insect population structure: complex variation in a checkerspot butterfly. Palo, J., Varvio, S.L., Hanski, I., Väinölä, R. Hereditas (1995) [Pubmed]
  12. Identification of human second, third, and fourth metatarsal bones. Batmanabane, M., Malathi, S. Anat. Rec. (1983) [Pubmed]
  13. Refining the perfusion-diffusion mismatch hypothesis. Butcher, K.S., Parsons, M., MacGregor, L., Barber, P.A., Chalk, J., Bladin, C., Levi, C., Kimber, T., Schultz, D., Fink, J., Tress, B., Donnan, G., Davis, S. Stroke (2005) [Pubmed]
  14. PET evaluation of fatty tumors in the extremity: possibility of using the standardized uptake value (SUV) to differentiate benign tumors from liposarcoma. Suzuki, R., Watanabe, H., Yanagawa, T., Sato, J., Shinozaki, T., Suzuki, H., Endo, K., Takagishi, K. Annals of nuclear medicine. (2005) [Pubmed]
 
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