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MeSH Review

Venous Pressure

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Disease relevance of Venous Pressure


Psychiatry related information on Venous Pressure

  • Inflation of a balloon at the right superior vena caval/right atrial junction of the rat causes no change in arterial or venous blood pressure but does attenuate spontaneous night-time drinking and the acute responses to 24 h water deprivation and s.c. isoprenaline [6].

High impact information on Venous Pressure

  • Increasing hepatic venous pressure to elevate portal venous pressure to the same level as that achieved with acetylcholine resulted in a similar increase in splanchnic vascular volume [7].
  • The increase in lobar arterial and venous pressure in response to either injected norepinephrine or to nerve stimulation was antagonized by an alpha receptor blocking agent [8].
  • METHODS: In protocol 1, 13 patients had measurements of the hepatic venous pressure gradient, hepatic blood flow, mean arterial pressure, cardiac output, and nitric oxide products before and 30 and 60 minutes after 40 mg of simvastatin [9].
  • RESULTS: In protocol 1, acute simvastatin did not modify the hepatic venous pressure gradient but increased the hepatic blood flow (21% +/- 13% at 30 minutes; P = 0.01) and decreased hepatic sinusoidal resistance by 14% +/- 11% (P = 0.04) [9].
  • METHODS: The portal vein of wild-type mice, or those with targeted mutations in the nos2 gene (iNOS) or the nos3 gene (eNOS), was ligated and portal venous pressure (Ppv), abdominal aortic blood flow (Qao), and portosystemic shunt determined 2 weeks later [10].

Chemical compound and disease context of Venous Pressure


Biological context of Venous Pressure


Anatomical context of Venous Pressure


Associations of Venous Pressure with chemical compounds

  • Propranolol to lower portal venous pressure [26].
  • At this level vasopressin was found to increase both systemic (Pa) and local (Pma) arterial pressures while decreasing superior mesenteric venous pressure (Pv), capillary pressure (PC) and blood flow (QB) [27].
  • It is concluded that the two different doses of octreotide administration result in the reduction of the wedge hepatic venous pressure and the hepatic blood flow of a similar magnitude, whereas the hepatic venous pressure gradient is unaffected [28].
  • Prazosin decreased the hepatic venous pressure gradient (HVPG) while increasing hepatic blood flow [29].
  • While measuring arterial pressure, colonic blood flow, venous pressure, and arteriovenous O2 difference, a Tyrode's solution containing acetic (75 mM), propionic (30 mM), and butyric acids (30 mM) was placed into the colon lumen [30].

Gene context of Venous Pressure

  • IGFBP-3 correlated significantly with the wedged hepatic venous pressure (r = -0.49; P < 0.05), serum aspartate aminotransferase (r = -0.66; P < 0.01), serum bilirubin (r = -0.65; P < 0.01), serum albumin (r = 0.64; P < 0.01), and the Child score (r = -0.57; P < 0.01) [31].
  • Adequate liver regeneration requires an adequate increase in portal venous pressure and flow reflected by clearance of HGF and elevated VEGF levels [32].
  • The pressor response to ET-1 was determined in vitro using isolated vascular rings and in vivo by measuring mean arterial pressure, splanchnic blood flow, and portal venous pressure following treatment with ET and selective ET receptor antagonists [33].
  • There was no significant difference in the peak splanchnic blood flow or portal venous pressure response following ET-A receptor blockade with JKC-301 infusion (200 microg/kg intravenously) [33].
  • In contrast, ET-B receptor blockade with IRL-1038 (200 microg/kg intravenously) preferentially decreased splanchnic blood flow and portal venous pressure in portal hypertensive rats [33].

Analytical, diagnostic and therapeutic context of Venous Pressure


  1. Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study. Lebrec, D., Poynard, T., Hillon, P., Benhamou, J.P. N. Engl. J. Med. (1981) [Pubmed]
  2. Oral administration of clonidine in patients with alcoholic cirrhosis. Hemodynamic and liver function effects. Albillos, A., Bañares, R., Barrios, C., Clemente, G., Rossi, I., Escartin, P., Bosch, J. Gastroenterology (1992) [Pubmed]
  3. Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage. Groszmann, R.J., Bosch, J., Grace, N.D., Conn, H.O., Garcia-Tsao, G., Navasa, M., Alberts, J., Rodes, J., Fischer, R., Bermann, M. Gastroenterology (1990) [Pubmed]
  4. Lack of effects of isosorbide-5-mononitrate on hepatic hemodynamics in HBsAg-positive cirrhosis. Tsai, Y.T., Lee, F.Y., Lin, H.C., Chang, T.T., Lay, C.S., Wang, S.S., Kong, C.W., Lee, S.D., Lo, K.J. Hepatology (1989) [Pubmed]
  5. Portal venous-esophageal luminal pressure gradient in cirrhosis. Reding, P., Urbain, D., Grivegnee, A., Frere, D. Hepatology (1986) [Pubmed]
  6. The role of the heart in body fluid and electrolyte homeostasis. Kaufman, S. J. Physiol. (Paris) (1984) [Pubmed]
  7. Effect of acetylcholine on vascular capacity in the dog. Supple, E.W., Powell, W.J. J. Clin. Invest. (1981) [Pubmed]
  8. Influence of sympathetic stimulation and vasoactive substances on the canine pulmonary veins. Kadowitz, P.J., Joiner, P.D., Hyman, A.L. J. Clin. Invest. (1975) [Pubmed]
  9. Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis. Zafra, C., Abraldes, J.G., Turnes, J., Berzigotti, A., Fernández, M., Garca-Pagán, J.C., Rodés, J., Bosch, J. Gastroenterology (2004) [Pubmed]
  10. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Theodorakis, N.G., Wang, Y.N., Skill, N.J., Metz, M.A., Cahill, P.A., Redmond, E.M., Sitzmann, J.V. Gastroenterology (2003) [Pubmed]
  11. Circulatory function and hepatorenal syndrome in cirrhosis. Ruiz-del-Arbol, L., Monescillo, A., Arocena, C., Valer, P., Ginès, P., Moreira, V., Milicua, J.M., Jiménez, W., Arroyo, V. Hepatology (2005) [Pubmed]
  12. The hemodynamic effect of verapamil on portal hypertension in patients with postnecrotic cirrhosis. Kong, C.W., Lay, C.S., Tsai, Y.T., Yeh, C.L., Lai, K.H., Lee, S.D., Lo, K.J., Chiang, B.N. Hepatology (1986) [Pubmed]
  13. Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: search for an additive effect. Hadengue, A., Moreau, R., Cerini, R., Koshy, A., Lee, S.S., Lebrec, D. Hepatology (1989) [Pubmed]
  14. Effects of captopril on hepatic venous pressure and blood flow in patients with liver cirrhosis. Eriksson, L.S., Kågedal, B., Wahren, J. Am. J. Med. (1984) [Pubmed]
  15. Portal hypertension in acute liver failure. Navasa, M., Garcia-Pagán, J.C., Bosch, J., Riera, J.R., Bañares, R., Mas, A., Bruguera, M., Rodés, J. Gut (1992) [Pubmed]
  16. Effects of vasopressin on portal pressure during hemorrhage from esophageal varices. Ready, J.B., Robertson, A.D., Rector, W.G. Gastroenterology (1991) [Pubmed]
  17. Effects of propranolol on renal blood flow and renal function in patients with cirrhosis. Bataille, C., Bercoff, E., Pariente, E.A., Valla, D., Lebrec, D. Gastroenterology (1984) [Pubmed]
  18. Autoregulation of blood flow within individual arterioles in the rat cremaster muscle. Morff, R.J., Granger, H.J. Circ. Res. (1982) [Pubmed]
  19. Hemodynamic effects of a combination of vasopressin and ketanserin in patients with hepatitis b-related cirrhosis. Lee, F.Y., Tsai, Y.T., Lin, H.C., Lee, S.D., Hsia, H.C., Lin, W.J., Wang, S.S., Lai, K.H., Lo, K.J. J. Hepatol. (1992) [Pubmed]
  20. Divergence of intracranial and central venous pressures in lightly anesthetized, tracheally intubated dogs that move in response to a noxious stimulus. Lanier, W.L., Albrecht, R.F., Laizzo, P.A. Anesthesiology (1996) [Pubmed]
  21. Sympathetic tone modulates portal venous pressure in alcoholic cirrhosis. Willett, I.R., Esler, M., Jennings, G., Dudley, F.J. Lancet (1986) [Pubmed]
  22. Role of veins and cerebral venous pressure in disruption of the blood-brain barrier. Mayhan, W.G., Heistad, D.D. Circ. Res. (1986) [Pubmed]
  23. Effect of propranolol on hepatic and systemic hemodynamics in dogs with chronic bile duct ligation. Willems, B., Villeneuve, J.P., Huet, P.M. Hepatology (1986) [Pubmed]
  24. Vasopressin and vasopressin plus nitroglycerin for portal hypertension. Effects on systemic and splanchnic hemodynamics and coronary blood flow. Rector, W.G., Hossack, K.F. J. Hepatol. (1989) [Pubmed]
  25. The ocular hypotensive effects of demeclocycline, tetracycline and other tetracycline derivatives. Wallace, I., Krupin, T., Stone, R.A., Moolchandani, J. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  26. Propranolol to lower portal venous pressure. Fleishman, S.J. Lancet (1981) [Pubmed]
  27. Effects of arginine vasopressin on capillary filtration in the cat ileum. Quillen, E.W., Granger, D.N., Taylor, A.E. Gastroenterology (1977) [Pubmed]
  28. Hemodynamic evaluation of octreotide in patients with hepatitis B-related cirrhosis. Lin, H.C., Tsai, Y.T., Lee, F.Y., Lee, S.D., Hsia, H.C., Lin, W.J., Lo, K.J. Gastroenterology (1992) [Pubmed]
  29. Continuous prazosin administration in cirrhotic patients: effects on portal hemodynamics and on liver and renal function. Albillos, A., Lledó, J.L., Rossi, I., Pérez-Páramo, M., Tabuenca, M.J., Bañares, R., Iborra, J., Garrido, A., Escartín, P., Bosch, J. Gastroenterology (1995) [Pubmed]
  30. Effect of volatile fatty acids on blood flow and oxygen uptake by the dog colon. Kvietys, P.R., Granger, D.N. Gastroenterology (1981) [Pubmed]
  31. Concentrations, release, and disposal of insulin-like growth factor (IGF)-binding proteins (IGFBP), IGF-I, and growth hormone in different vascular beds in patients with cirrhosis. Møller, S., Juul, A., Becker, U., Flyvbjerg, A., Skakkebaek, N.E., Henriksen, J.H. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  32. Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation. Yagi, S., Iida, T., Taniguchi, K., Hori, T., Hamada, T., Fujii, K., Mizuno, S., Uemoto, S. Liver Transpl. (2005) [Pubmed]
  33. Increased expression of endothelin receptors in the vasculature of portal hypertensive rats: role in splanchnic hemodynamics. Cahill, P.A., Hou, M.C., Hendrickson, R., Wang, Y.N., Zhang, S., Redmond, E.M., Sitzman, J.V. Hepatology (1998) [Pubmed]
  34. Vascular responses to arachidonic acid in the perfused canine lung. Wicks, T.C., Rose, J.C., Johnson, M., Ramwell, P.W., Kot, P.A. Circ. Res. (1976) [Pubmed]
  35. The effect of propranolol on portal hypertension in patients with cirrhosis: a hemodynamic study. Lebrec, D., Hillon, P., Muńoz, C., Goldfarb, G., Nouel, O., Benhamou, J.P. Hepatology (1982) [Pubmed]
  36. Gastro-intestinal protein loss in late survivors of Fontan surgery and other congenital heart disease. Thorne, S.A., Hooper, J., Kemp, M., Somerville, J. Eur. Heart J. (1998) [Pubmed]
  37. Gaseous oxygen perfusion of the renal vessels as an adjunct in kidney preservation. Ross, H., Escott, M.L. Transplantation (1979) [Pubmed]
  38. Verapamil has no effect on porto-hepatic pressure gradient, hepatic blood flow and elimination function of the liver in patients with liver cirrhosis. Vinel, J.P., Caucanas, J.P., Combis, J.M., Cales, P., Voigt, J.J., Pascal, J.P. J. Hepatol. (1989) [Pubmed]
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