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Gene Review

Cebpa  -  CCAAT/enhancer binding protein (C/EBP), alpha

Mus musculus

Synonyms: C/EBP alpha, C/ebpalpha, CBF-A, CCAAT/enhancer-binding protein alpha, Cebp
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High impact information on Cebpa


Biological context of Cebpa


Anatomical context of Cebpa


Associations of Cebpa with chemical compounds


Other interactions of Cebpa


  1. AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Pabst, T., Mueller, B.U., Harakawa, N., Schoch, C., Haferlach, T., Behre, G., Hiddemann, W., Zhang, D.E., Tenen, D.G. Nat. Med. (2001) [Pubmed]
  2. Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Hsu, C.L., King-Fleischman, A.G., Lai, A.Y., Matsumoto, Y., Weissman, I.L., Kondo, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. C/EBPalpha is required for differentiation of white, but not brown, adipose tissue. Linhart, H.G., Ishimura-Oka, K., DeMayo, F., Kibe, T., Repka, D., Poindexter, B., Bick, R.J., Darlington, G.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Jenkins, N.A., Gilbert, D.J., Cho, B.C., Strobel, M.C., Williams, S.C., Copeland, N.G., Johnson, P.F. Genomics (1995) [Pubmed]
  5. Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification. Ford, A.M., Bennett, C.A., Healy, L.E., Towatari, M., Greaves, M.F., Enver, T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Yamasaki, H., Sada, A., Iwata, T., Niwa, T., Tomizawa, M., Xanthopoulos, K.G., Koike, T., Shiojiri, N. Development (2006) [Pubmed]
  7. Sequential repression and activation of the CCAAT enhancer-binding protein-alpha (C/EBPalpha ) gene during adipogenesis. Jiang, M.S., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. Small interfering RNA knockdown of calcium-independent phospholipases A2 beta or gamma inhibits the hormone-induced differentiation of 3T3-L1 preadipocytes. Su, X., Mancuso, D.J., Bickel, P.E., Jenkins, C.M., Gross, R.W. J. Biol. Chem. (2004) [Pubmed]
  9. CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes. Mackey, S.L., Darlington, G.J. J. Biol. Chem. (2004) [Pubmed]
  10. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Zhang, D.E., Zhang, P., Wang, N.D., Hetherington, C.J., Darlington, G.J., Tenen, D.G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  11. C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Heath, V., Suh, H.C., Holman, M., Renn, K., Gooya, J.M., Parkin, S., Klarmann, K.D., Ortiz, M., Johnson, P., Keller, J. Blood (2004) [Pubmed]
  12. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Bassères, D.S., Levantini, E., Ji, H., Monti, S., Elf, S., Dayaram, T., Fenyus, M., Kocher, O., Golub, T., Wong, K.K., Halmos, B., Tenen, D.G. Mol. Cell. Biol. (2006) [Pubmed]
  13. Ritonavir increases the level of active ADD-1/SREBP-1 protein during adipogenesis. Nguyen, A.T., Gagnon, A., Angel, J.B., Sorisky, A. AIDS (2000) [Pubmed]
  14. Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes. Tafuri, S.R. Endocrinology (1996) [Pubmed]
  15. Notch 1 impairs osteoblastic cell differentiation. Sciaudone, M., Gazzerro, E., Priest, L., Delany, A.M., Canalis, E. Endocrinology (2003) [Pubmed]
  16. The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Xanthopoulos, K.G., Mirkovitch, J., Friedman, J.M., Darnell, J.E. Cytogenet. Cell Genet. (1989) [Pubmed]
  17. C/EBPalpha is required to maintain postmitotic growth arrest in adipocytes. Tao, H., Umek, R.M. DNA Cell Biol. (2000) [Pubmed]
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