The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Onecut1  -  one cut domain, family member 1

Mus musculus

Synonyms: D9Ertd423e, HNF-6, HNF6, Hepatocyte nuclear factor 6, Hfh12, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Onecut1


High impact information on Onecut1


Chemical compound and disease context of Onecut1


Biological context of Onecut1


Anatomical context of Onecut1


Associations of Onecut1 with chemical compounds

  • In conclusion, the HNF-6 protein is a component of the complex network of hepatic transcription factors that regulates the expression of hepatic genes essential for bile acid homeostasis and cholesterol/lipid metabolism in normal and pathological conditions [11].
  • HNF-6 binds to DNA as a monomer utilizing a single cut domain and a divergent homeodomain motif located at its C terminus [12].
  • These results suggest that downregulation of Hnf6 expression in beta-cells during development is essential to achieve a mature, glucose-responsive beta-cell [13].

Physical interactions of Onecut1

  • RESULTS: HNF-6 bound to the hepatic promoter of the glucokinase gene and stimulated its activity [14].
  • OC-3 has a DNA-binding specificity similar to that of HNF-6 and it is a stimulator of gene transcription [15].
  • Again, we found no evidence that HNF6 binding to its targets in chromatin is reduced in the presence of Foxa2 [16].

Enzymatic interactions of Onecut1


Regulatory relationships of Onecut1

  • We hypothesized that HNF-6 controls the activity of the hepatic glucokinase promoter [14].
  • We investigated how HNF-6 controls the expression of Foxa1 [10].
  • The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas [1].
  • Moreover, HNF-6 could directly stimulate the Pdx1 promoter [17].
  • We showed previously that the Onecut transcription factor HNF-6 promotes differentiation of the endocrine cell precursors in which it stimulates expression of the proendocrine gene Ngn-3 [17].

Other interactions of Onecut1

  • We show that HNF-6, OC-2, and OC-3 are expressed sequentially, which defines new steps in endoderm differentiation [7].
  • Inactivation of the hnf6 gene did not modify the pattern of deoxyribonuclease I hypersensitive sites but was associated with a decrease of liver glucokinase mRNA to half the control value [14].
  • A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells [8].
  • A 516-bp fragment, encompassing a DNase I-hypersensitive site associated with P2 activity that is still retained in adult liver, contains functional HNF1 and HNF6 binding sites and confers full promoter activity in transient transfections [18].
  • Because no evidence for a direct repression of Foxa1 by HNF-6 was found, we postulated the existence of an indirect mechanism [10].

Analytical, diagnostic and therapeutic context of Onecut1


  1. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Rausa, F., Samadani, U., Ye, H., Lim, L., Fletcher, C.F., Jenkins, N.A., Copeland, N.G., Costa, R.H. Dev. Biol. (1997) [Pubmed]
  2. Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction. Holterman, A.X., Tan, Y., Kim, W., Yoo, K.W., Costa, R.H. Hepatology (2002) [Pubmed]
  3. The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. Bouzin, C., Clotman, F., Renauld, J.C., Lemaigre, F.P., Rousseau, G.G. J. Immunol. (2003) [Pubmed]
  4. Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration. Tan, Y., Yoshida, Y., Hughes, D.E., Costa, R.H. Gastroenterology (2006) [Pubmed]
  5. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Clotman, F., Jacquemin, P., Plumb-Rudewiez, N., Pierreux, C.E., Van der Smissen, P., Dietz, H.C., Courtoy, P.J., Rousseau, G.G., Lemaigre, F.P. Genes Dev. (2005) [Pubmed]
  6. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Pierreux, C.E., Poll, A.V., Kemp, C.R., Clotman, F., Maestro, M.A., Cordi, S., Ferrer, J., Leyns, L., Rousseau, G.G., Lemaigre, F.P. Gastroenterology (2006) [Pubmed]
  7. The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm. Pierreux, C.E., Vanhorenbeeck, V., Jacquemin, P., Lemaigre, F.P., Rousseau, G.G. J. Biol. Chem. (2004) [Pubmed]
  8. A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells. Poll, A.V., Pierreux, C.E., Lokmane, L., Haumaitre, C., Achouri, Y., Jacquemin, P., Rousseau, G.G., Cereghini, S., Lemaigre, F.P. Diabetes (2006) [Pubmed]
  9. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Samadani, U., Costa, R.H. Mol. Cell. Biol. (1996) [Pubmed]
  10. Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Plumb-Rudewiez, N., Clotman, F., Strick-Marchand, H., Pierreux, C.E., Weiss, M.C., Rousseau, G.G., Lemaigre, F.P. Hepatology (2004) [Pubmed]
  11. In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction. Wang, M., Tan, Y., Costa, R.H., Holterman, A.X. Hepatology (2004) [Pubmed]
  12. Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA. Sheng, W., Yan, H., Rausa, F.M., Costa, R.H., Liao, X. J. Biol. Chem. (2004) [Pubmed]
  13. Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of {beta}-Cells. Tweedie, E., Artner, I., Crawford, L., Poffenberger, G., Thorens, B., Stein, R., Powers, A.C., Gannon, M. Diabetes (2006) [Pubmed]
  14. Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6. Lannoy, V.J., Decaux, J.F., Pierreux, C.E., Lemaigre, F.P., Rousseau, G.G. Diabetologia (2002) [Pubmed]
  15. OC-3, a novel mammalian member of the ONECUT class of transcription factors. Vanhorenbeeck, V., Jacquemin, P., Lemaigre, F.P., Rousseau, G.G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  16. Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2. Rubins, N.E., Friedman, J.R., Le, P.P., Zhang, L., Brestelli, J., Kaestner, K.H. Mol. Cell. Biol. (2005) [Pubmed]
  17. The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Jacquemin, P., Lemaigre, F.P., Rousseau, G.G. Dev. Biol. (2003) [Pubmed]
  18. Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver. Briançon, N., Bailly, A., Clotman, F., Jacquemin, P., Lemaigre, F.P., Weiss, M.C. J. Biol. Chem. (2004) [Pubmed]
WikiGenes - Universities