The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ccr8  -  chemokine (C-C motif) receptor 8

Mus musculus

Synonyms: C-C, C-C CKR-8, C-C chemokine receptor type 8, CC-CKR-8, CCR-8, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ccr8

  • Using two different protocols of allergen challenge, we demonstrate that absence of CCR8 does not affect the development of pulmonary eosinophilia and Th2 cytokine responses [1].
  • All CCR8(-/-) mice developed a pathological response similar to that of wild-type animals with respect to bronchoalveolar lavage cell composition, peripheral blood and bone marrow eosinophilia, lung infiltrates, and Th2 cytokine levels in lung and serum [2].
  • Transcript analysis of CD4+ T cells generated during schistosome granuloma formation failed to show biased CCR8 expression but, having a more limited receptor repertoire, these cells were likely more dependent on CCR8 ligands [3].
  • In the present study, we demonstrate that CC chemokine receptor 8 (CCR8) skews innate immune response during septic peritonitis induced by cecal ligation and puncture (CLP) [4].

High impact information on Ccr8

  • These results indicate an important role for CCR8 in Th2 functional responses in vivo [5].
  • Similar immune responses were also observed in CCR8(-/-) and wild-type animals in a different model of ragweed allergen-induced peritoneal eosinophilic inflammation, with an equivalent number of eosinophils and analogous increased levels of Th2 cytokines in peritoneum and peripheral blood [2].
  • Our results show that allergic diseases course without critical CCR8 participation, and suggest that further work is needed to unravel the in vivo role of CCR8 in Th2-mediated pathologies [2].
  • Using CCR8(-/-) mice, evidence is provided that TCA3-CCR8 interactions contribute to rapid-onset CNS inflammation [6].
  • A number of receptors are preferentially expressed on Th2 cells, including CCR4, CCR8, and CxCR4 [7].

Biological context of Ccr8

  • The murine CCR8 (mCCR8) gene was cloned, and its predicted amino acid sequence showed a 71% identity with that of human CCR8 [8].
  • Altogether, these results indicate that CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity [4].
  • These differences were correlated with distinctive extents of Cx43 phosphorylation in the two cell populations, a lower phosphorylation with high NAD(+) transport (CD38(-) cells) and vice versa (CD38(+) cells) [9].

Anatomical context of Ccr8


Associations of Ccr8 with chemical compounds


Analytical, diagnostic and therapeutic context of Ccr8

  • We generated CCR8-deficient mice (CCR8(-/-)) to study the in vivo role of this receptor, and describe in this study the CCR8(-/-) mouse response in OVA-induced allergic airway disease using several models, including an adoptive transfer model and receptor-blocking experiments [2].


  1. CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease. Chung, C.D., Kuo, F., Kumer, J., Motani, A.S., Lawrence, C.E., Henderson, W.R., Venkataraman, C. J. Immunol. (2003) [Pubmed]
  2. Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease. Goya, I., Villares, R., Zaballos, A., Gutiérrez, J., Kremer, L., Gonzalo, J.A., Varona, R., Carramolino, L., Serrano, A., Pallarés, P., Criado, L.M., Kolbeck, R., Torres, M., Coyle, A.J., Gutiérrez-Ramos, J.C., Martínez-A, C., Márquez, G. J. Immunol. (2003) [Pubmed]
  3. Chemokine responses in schistosomal antigen-elicited granuloma formation. Chiu, B.C., Chensue, S.W. Parasite Immunol. (2002) [Pubmed]
  4. Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis. Matsukawa, A., Kudoh, S., Sano, G., Maeda, T., Ito, T., Lukacs, N.W., Hogaboam, C.M., Kunkel, S.L., Lira, S.A. FASEB J. (2006) [Pubmed]
  5. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. Chensue, S.W., Lukacs, N.W., Yang, T.Y., Shang, X., Frait, K.A., Kunkel, S.L., Kung, T., Wiekowski, M.T., Hedrick, J.A., Cook, D.N., Zingoni, A., Narula, S.K., Zlotnik, A., Barrat, F.J., O'Garra, A., Napolitano, M., Lira, S.A. J. Exp. Med. (2001) [Pubmed]
  6. Interactions between hemopoietically derived TNF and central nervous system-resident glial chemokines underlie initiation of autoimmune inflammation in the brain. Murphy, C.A., Hoek, R.M., Wiekowski, M.T., Lira, S.A., Sedgwick, J.D. J. Immunol. (2002) [Pubmed]
  7. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Lukacs, N.W., Berlin, A., Schols, D., Skerlj, R.T., Bridger, G.J. Am. J. Pathol. (2002) [Pubmed]
  8. Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. Goya, I., Gutiérrez, J., Varona, R., Kremer, L., Zaballos, A., Márquez, G. J. Immunol. (1998) [Pubmed]
  9. A self-restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts. Bruzzone, S., Franco, L., Guida, L., Zocchi, E., Contini, P., Bisso, A., Usai, C., De Flora, A. J. Biol. Chem. (2001) [Pubmed]
  10. CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. Liu, J.X., Cao, X., Tang, Y.C., Liu, Y., Tang, F.R. J. Neurochem. (2007) [Pubmed]
WikiGenes - Universities