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Gene Review

Ccl1  -  chemokine (C-C motif) ligand 1

Mus musculus

Synonyms: BF534335, C-C motif chemokine 1, CCR8 ligand, I-309, P500, ...
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Disease relevance of Ccl1


High impact information on Ccl1


Biological context of Ccl1


Anatomical context of Ccl1


Associations of Ccl1 with chemical compounds


Other interactions of Ccl1

  • Using antibodies specific for CCR5 and CCR8, the chemotactic response to MIP-1beta and TCA-3, respectively, was reduced significantly [13].
  • In addition, 11 members of the Scya gene family were found to be organized into two clusters at the borders of the Om region [17].
  • Using CCR8(-/-) mice, evidence is provided that TCA3-CCR8 interactions contribute to rapid-onset CNS inflammation [2].
  • Furthermore, TCA3 does not induce a Ca2 lux in cells transfected with cDNA for the C-C CKR-1 chemokine receptor, supporting the conclusion that there are distinct receptors for TCA3 [14].
  • The TCA3 gene encodes a proinflammatory cytokine related to IL-8 and MCP-1 (JE) [18].

Analytical, diagnostic and therapeutic context of Ccl1

  • Northern blot analysis showed that TCA3 message appeared in mast cells within 2 h after induction, with a t1/2 of 30 min [11].
  • A sensitive and specific capture ELISA for TCA3 quantitation was developed, allowing measurement of TCA3 levels in the supernatants from activated murine splenocytes and T cell clones [18].
  • Western blotting also demonstrated that all four mAb specifically recognize rTCA3, native TCA3 produced by activated mouse T cells, and the nonglycosylated TCA3 core protein [18].
  • We compared by reverse transcriptase PCR the thyroidal expression of 10 chemokines (CCL1 through 5 and CXCL9 through 13) in thyr-IFNgamma transgenics and wild-type littermates [19].
  • Moreover, intranasal administration of BP to mice enhanced mRNA levels of TCA3, the mouse orthologue of CCL1, in lung [20].


  1. CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease. Bishop, B., Lloyd, C.M. J. Immunol. (2003) [Pubmed]
  2. Interactions between hemopoietically derived TNF and central nervous system-resident glial chemokines underlie initiation of autoimmune inflammation in the brain. Murphy, C.A., Hoek, R.M., Wiekowski, M.T., Lira, S.A., Sedgwick, J.D. J. Immunol. (2002) [Pubmed]
  3. Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. Doyle, H.A., Murphy, J.W. J. Immunol. (1999) [Pubmed]
  4. Cloning and characterization of a novel T cell activation gene. Burd, P.R., Freeman, G.J., Wilson, S.D., Berman, M., DeKruyff, R., Billings, P.R., Dorf, M.E. J. Immunol. (1987) [Pubmed]
  5. The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway. Spinetti, G., Bernardini, G., Camarda, G., Mangoni, A., Santoni, A., Capogrossi, M.C., Napolitano, M. J. Leukoc. Biol. (2003) [Pubmed]
  6. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. Tiffany, H.L., Lautens, L.L., Gao, J.L., Pease, J., Locati, M., Combadiere, C., Modi, W., Bonner, T.I., Murphy, P.M. J. Exp. Med. (1997) [Pubmed]
  7. Clustering of cytokine genes on mouse chromosome 11. Wilson, S.D., Billings, P.R., D'Eustachio, P., Fournier, R.E., Geissler, E., Lalley, P.A., Burd, P.R., Housman, D.E., Taylor, B.A., Dorf, M.E. J. Exp. Med. (1990) [Pubmed]
  8. Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Haque, N.S., Fallon, J.T., Pan, J.J., Taubman, M.B., Harpel, P.C. Blood (2004) [Pubmed]
  9. Production and function of monocyte chemoattractant protein-1 and other beta-chemokines in murine glial cells. Hayashi, M., Luo, Y., Laning, J., Strieter, R.M., Dorf, M.E. J. Neuroimmunol. (1995) [Pubmed]
  10. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. Zingoni, A., Soto, H., Hedrick, J.A., Stoppacciaro, A., Storlazzi, C.T., Sinigaglia, F., D'Ambrosio, D., O'Garra, A., Robinson, D., Rocchi, M., Santoni, A., Zlotnik, A., Napolitano, M. J. Immunol. (1998) [Pubmed]
  11. Transcriptional regulation of the TCA3 gene in mast cells after Fc epsilon RI cross-linking. Oh, C.K., Metcalfe, D.D. J. Immunol. (1994) [Pubmed]
  12. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. Miller, M.D., Wilson, S.D., Dorf, M.E., Seuanez, H.N., O'Brien, S.J., Krangel, M.S. J. Immunol. (1990) [Pubmed]
  13. Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. Oliveira, S.H., Lira, S., Martinez-A, C., Wiekowski, M., Sullivan, L., Lukacs, N.W. J. Leukoc. Biol. (2002) [Pubmed]
  14. Biologic activities of the murine beta-chemokine TCA3. Luo, Y., Laning, J., Devi, S., Mak, J., Schall, T.J., Dorf, M.E. J. Immunol. (1994) [Pubmed]
  15. Biologic activities of the beta-chemokine TCA3 on neutrophils and macrophages. Devi, S., Laning, J., Luo, Y., Dorf, M.E. J. Immunol. (1995) [Pubmed]
  16. Inhibition of in vivo tumor growth by the beta chemokine, TCA3. Laning, J., Kawasaki, H., Tanaka, E., Luo, Y., Dorf, M.E. J. Immunol. (1994) [Pubmed]
  17. A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11. Cohen-Tannoudji, M., Vandormael-Pournin, S., Le Bras, S., Coumailleau, F., Babinet, C., Baldacci, P. Genomics (2000) [Pubmed]
  18. Serologic analysis of a murine chemokine, TCA3. Luo, Y., Laning, J., Dorf, M.E. J. Immunol. (1993) [Pubmed]
  19. Early chemokine expression induced by interferon-gamma in a murine model of Hashimoto's thyroiditis. Kimura, H., Kimura, M., Rose, N.R., Caturegli, P. Exp. Mol. Pathol. (2004) [Pubmed]
  20. Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene. N'Diaye, M., Le Ferrec, E., Lagadic-Gossmann, D., Corre, S., Gilot, D., Lecureur, V., Monteiro, P., Rauch, C., Galibert, M.D., Fardel, O. J. Biol. Chem. (2006) [Pubmed]
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